T cell immunologist who wants to understand physiological and pathological #T cell effector function. Great love for #RNA biology, #Sanquin, #OncodeInstitute
This is a many-years study, started by Marleen Van Loenen, continued by Rosa de Groot, and now analysed and written up by Suzanne Castenmiller and Nandhini Kanagasabesan, w supported by Aurélie Guislain and Benoit Nicolet, PhD
Great collaboration with the medical team from the AvL-NKI, with
Koen Hartemink, Kim Monkhorst, Alexander Veenhof, Egbert Smit en John Haanen
Supported by Sanquin Blood Supply Foundation funding and Oncode Institute
Now In press!!!
We came to the surprising conclusion that (contrary to what is reported for responsiveness to immunotherapy), the tumor reactivity of TIL products negatively correlates with the amount of B cell/ naive T cell infiltrates in the tumor.
We also have a hypothesis as to why that is.
Interested? Check it our!
May I suggest getting a public library card?
I access almost all paywalled material for free via PressReader using my public library.
If you live in a red state, Brooklyn Public Library offers services to victims of GOP book bans & other attacks on literate citizenship. Ditto Boston Public Library.
I refuse to accept when it hits family life. Does it hurt my career? Don't think so. And if it does? Well, bad luck. They cannot complain about too few children in our society while making it impossible for women to combine work with family life. I must add: i was blessed with understanding colleagues. But culture changes from within. I also strongly believe it is important to show the next generation that a job does not mean sacrificing everything.
Sad news: Frans de Waal — Ig Nobel Prize-winning biologist who studied the many odd ways that monkeys and humans and other primates behave — has died. https://improbable.com/2024/03/16/sad-news-frans-de-waal-is-gone/
An experience of time tracking as a scientist https://www.nature.com/articles/d41586-024-00806-1
Not sure i am happy with this. In the NL we already have this in place. Does it really help? I think
1) evaluation highly (and too much) depends on the writing style (not so much on the achievements themselves). And this type of writing TMO does not necessarily reflect how good a researcher is.
2) is even more difficult for the reviewer to extract the prime evaluation points
TMO a list would also allow to include non-classical achievements, parts of contribution, etc.
#ERC
Please find below our most recent pre-print. We studied the role of the RNA binding protein ZFP36L2 in effector T cells and found how it regulated the production of IFNgamma in late T cell responses and continuous activation with tumor cells (in vitro/in vivo). Happy reading!
https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics
As much as i am horrified about the neo-fascist developments in Germany, i am just very proud of the citizens of my home country to step up and clarify that the 'silent' majority absolutely does NOT support this AfD rubbish, and that it starts speaking up. I very much hope that this is just the start for a Europe wide- what do I say - world wide movement for stepping up!
https://www.tagesschau.de/inland/gesellschaft/demonstrationen-gegen-rechts-sonntag-100.html
"Integrative analysis of #neuroblastoma by single-cell RNA sequencing identifies the #NECTIN2-#TIGIT axis as a target for #immunotherapy"
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00436-1
Great new work from Judith Wienke et al. from the Molenaar lab in the #PrincessMaximaCenter in #Utrecht.
Great to see this out after seeing it in our group meetings several times. In vivo results sometimes are impressive, but very much in a subgroup it seems. Intriguiging, and curious what underlies this.
Hey all!
In the new year, I would like to help build a flourishing #science community for #Immunology and #ComputationalBiology (since those are my main #research interests 🤓🙂)
Looking to follow more researchers/hashtags for sharing our work, so hook me up (even if they haven't been active in a while)!
Also, I'm planning to post more computational/immunology content. Please let me know in the poll below about what types of content you'd be interested in!
Boosts appreciated!
@hembrow
could not agree more with you. I also belong to the 'right immigrants' and cannot just fathom why it is all of the sudden considered 'ok' by so many people to have such people in the government. and that the other right wing parties sort of dance around it and also consider immigration the prime concern of this country ... it gives me a lot of heart pain.
"If you spend your life yelling at bad scientists, you’ll make yourself hoarse. If you spend your life trying to do great science, you might forever change the world for the better, which seems like a better use of time." – Adam Mastroianni
https://www.experimental-history.com/p/science-is-a-strong-link-problem
Ich weiß nicht wie es Euch geht! Ich habe einen Klimablues. Die Erkenntnisse, wie schlimm es ist und wird, werden immer präziser. Die Politik verliert sich im Klein Klein. Diskutiert sehr viel über Energie und Heizungen, aber wenig über einfache Sachen: Einfach weniger konsumieren, langsamer fahren und es muß nicht immer die Kreuzfahrt sein. In Bremerhaven liegen Wissenschaft und Politik örtlich eng zusammen, könnten aber nicht weiter voneinander entfernt sein.
We zijn begonnen! We laten massaal onze stem horen voor het klimaat en rechtvaardigheid 💪
#klimaatmars #decrisisisnu
@singingwolfboy
85.000 people- that was massive, no? and fantastic, all ages, types of people, really good to see how broad this topic is considered important.
Now it is to the politicians to move!!!
(and to the Dutch crowd to vote!)
You'll never guess what happened next...
"When the project was announced, in 2002, Biobank promised that data would not be given to insurance companies after concerns were raised that it could be used in a discriminatory way"
We invite you to join us at the Ig Nobel Show at Imperial College London, UK, on Saturday November 18, 2023. This resumes the long series of annual events that was interrupted by the pandemic. https://improbable.com/2023/10/23/ig-nobel-show-at-imperial-college-london/
I've tried to straddle the line on Twitter, hoping to keep dialogue open across communities and avoid furthering the polarisation by leaving the Birdsite with no advocates for better practice.
But I'm out. Deleting account today. I've been primarily Mastodon since Nov 2022 anyways. Thanks all for making Mastodon a proper community. 🙂 Celebrating one year! #MastodonMigration #twitterMigration
https://www.nature.com/articles/d41586-023-03483-8
