@tdverstynen @grimalkina structural integrity is not a joke, Jim!

Multiphoton imaging through 20 mm of air with the new Cousa objective.

This is a new type of objective: ultra long working distance, huge field-of-view, optimized for two-photon imaging.

And it fits on standard microscopes neuroscientists use for in vivo imaging (e.g., from Bruker, Thorlabs, Neurolabware, INSS, CoSys, etc.)!

The Cousa provides excellent data and even three-photon imaging over a huge field-of-view!

The paper has data from marmosets, tree shrews, both young and adult ferrets, intact pig eye, the first in vivo calcium imaging from mouse cochlear hair cells (!), beautiful input mapping / dendritic spine imaging, and more!

The paper was published just now: https://doi.org/10.1038/s41592-023-02098-1 It's open access. The Cousa objective can be purchased from a company that is being spun out of the lab: https://pacificoptica.com

@ct_bergstrom oh I think they know exactly how most academics feel about social interactions.

We've all been there: it's puzzle time, but once you dump out the pieces and start laying them flat, you realize you don't have enough space on your table. Join me as we use physics to find out ✨HOW BIG A TABLE YOU NEED FOR YOUR JIGSAW PUZZLE ✨

https://doi.org/10.48550/arXiv.2312.04588
#SciComm

How long-read sequencing will transform neuroscience.

By Tychele Turner

https://www.thetransmitter.org/whole-genome-sequencing/how-long-read-sequencing-will-transform-neuroscience/?utm_source=mastodon&utm_medium=org-social&utm_campaign=20231122-how-long-read-sequencing-will-transform-neuroscience

If you're seeing dire news about the water & alfalfa lately in the US, I have good news for you.

The US's water problems have solutions!

One of the most powerful solutions: give serious attention & investment to agriculture in the southeastern US.

Let's talk about just one way to do that.

@hedgielib @JMarkOckerbloom https://twitter.com/sbarolo/status/1036685010869407744?lang=en from the inimitable
@sbarolo @shrewshrew

Spam e-mails out here just targeting my inner supervillain now.

Hi #infosec community: any recommended practices for preventing a personal blog webpage from being dominated by crawlers?

The robots.txt seems largely ignored. Crawlers presently consume ~75% of resources according to the access logs.

I don't mind not being listed on any web search engines.

Would a basic auth work? Can one make the basic auth dialog show a message that provides the password hint in it, like "What is my first name?"

#blogging

Nadine Randel and I wrote a dispatch on the recent miniature-wasp eye #connectome paper
Have a look:
https://www.sciencedirect.com/science/article/pii/S096098222301432X?dgcid=author

and here is the original paper on the Megaphragma eye by Chua and colleagues https://www.sciencedirect.com/science/article/pii/S096098222301237X

#neuroscience #microscopy

If James Huntsman’s tithing suit against the LDS Church succeeds, nonprofits warn, it could devastate fundraising for all sorts of causes.
https://www.sltrib.com/religion/local/2023/11/26/why-even-nonreligious-charities/

@peggycollins this is fantastic I've never seen anything quite like it!

CBS News Sunday Morning showed my artwork "The Sun Shines on Dreamland" again today after a segment on the 100-year anniversary of the Alaska Railroad. See it at https://www.cbsnews.com/news/this-week-on-sunday-morning-june-4-2023/?intcid=CNM-00-10abd1h

Artwork available at https://peggy-collins.pixels.com/featured/the-sun-shines-on-dreamland-peggy-collins.html

#cbs #sundaymorning #sunday #sun #landscape #landscapeart #cbsnews #colorful #art #arte #psychedelic #wallartforsale #wallart #gifts #giftideas #interiordesign #homedecor #ayearforart #buyintoart #creativetoots #fediverse #fedigiftshop #mastodonart #mastoart

#nuclearenergy #SMRs
"This is obvious stuff looking backward from 2023. As I noted recently, nuclear energy and #freemarkets aren’t compatible. Nuclear programs are state programs with subordinate corporate partnerships.
No country globally has the conditions for success for nuclear generation in the 21st Century. That was a Cold War era success story…which is vastly diminished in the age of trade."
https://cleantechnica.com/2023/11/30/what-drives-this-madness-on-small-modular-nuclear-reactors/

@alicia_izquierdo there's just no accounting for taste I tell ya. More for the rest of us.

@alicia_izquierdo who hates panettone?

Loren Looger, legendary protein wrangler, who always generously shared their genetically encoded calcium indicators and more while still in development and unpublished, is asking for labs to co-write grants with him:

"Dear science world, I need help, please. If you like the tools and data we generate, and our shareware attitude, can you please co-apply for funding with us? It turns out that I'm terrible at writing grants, and we need $$ or else we can't make more GCaMPs, RCaMPs, SnFRs (we've branched out to neuromodulators and neuropeptides), FPs, viruses, tags, etc. We'll also make whatever you want, but we need $$ to do it. DM or email me, sooner is better. Sorry to be desperate, but we want to keep doing this, and I'm not sure we can."

https://profiles.ucsd.edu/loren.looger

#neuroscience #GCaMP #RCaMP #SnFR #ProteinEngineering #GECIs

Seeing the whole "Paris is considering coexisting with rats" recirculating https://www.insider.com/can-humans-and-rates-just-live-together-paris-new-york-2023-6 and PEOPLE we did this and it ends deliciously.