#Alleles

2024-04-26

Understanding the Principle of Independent Assortment in Genetics

, , , , , , , , , , , In the intricate world of genetics, where traits are passed down from generation to generation, one fundamental principle governs the inheritance of multiple traits simultaneously: the Principle of Independent…

micrordt.wordpress.com/2024/04

2024-04-25

Navigating the Genetic Lexicon: Understanding Key Terminology in Genetics

, , , , , , , , , , , , , Genetics is a fascinating field that explores the blueprint of life encoded within our DNA. However, delving into this complex world often feels like deciphering a cryptic language…

micrordt.wordpress.com/2024/04

#Human ancestry has been shaped by mixing and matching #alleles, show two recent studies.

#evolution #admixture #DNA #genomics

phys.org/news/2023-05-human-an

2023-02-21

Definitions 🧵:
A #haplogroup is a combination of #alleles that tend to be inherited together.
An #allele is a variation of the same sequence of nucleotides at the same place on a DNA molecule.

#Haplogroups pertain to a single line of descent. As such, individual membership of a haplogroup relies on a small proportion of the #genetic material possessed by that individual.

Mothers pass on mitochondrial #DNA unmixed to all their children; so the #ancestry can be traced along the maternal line.

Dezene Huber 🌻dezene@ecoevo.social
2023-02-13

It turns out that a section of our #DNA that we received from Neanderthals is particularly associated with outcomes (mild, severe) of #COVID19 infections.

This paper outlines an approach ranging from population genetics to functional #genomics in which the researchers identified four important #alleles and their likely #regulatory function.

Title: "Regulatory dissection of the severe #COVID-19 risk locus introgressed by #Neanderthals" (Jagoda et al. 2023)

Link: elifesciences.org/articles/712

Figure 5 text (quoted from the linked paper):

"Activity of four emVars in SARS-CoV-2 infected and uninfected A549-ACE2 cells using real-time PCR (qRTPCR).
(a, top) Diagram of construct design and experimental transfection setup. (a, bottom) Constructs tested using in vitro transfection in A549-ACE2 cells whose results are shown in (b) in color-coded fashion. (b) Box-whisker plot graph depicting the transcript level of GFP expression driven by the introgressed allele normalized by the non-introgressed allele for each emVar in mock infection (i.e., absense of SARS-CoV-2) (left, solid color boxes) vs SARS-CoV-2 infected (right, empty color boxes) cells. The ‘*’ depicts significant changes using Wilcoxon statistical test that had a p-value of <0.05 (n=3 per condition). (c) Bar plots showing the infection ratio for each construct."

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