#AmyotrophicLateralSclerosis

🤘 The Metal Dog 🤘TheMetalDog@mastodon.themetaldog.net
2025-06-29
2025-03-16

A devastating nerve disease stalks a mountain village.

Neurologists have grappled with a cluster of amyotrophic lateral sclerosis (ALS) cases in France, where a fondness for a toxic wild mushroom may hold the answer.

mediafaro.org/article/20250316

#Neurology #MotorNeuronDisease #Mushrooms #FalseMorels #Nature #AmyotrophicLateralSclerosis #ALS #France #Health #Science

David GraylessDavidGrayless
2025-02-24

in 2024, , Canadian (Star Trek: Discovery), died of at 49. 🕊

#OnThisDay in 1949, #LeadBelly, American blues 12-string guitarist (Rock Island Line), died of #amyotrophiclateralsclerosis at 64. 🪦
#RIP

DrBob, Retired 🧠 Mechanicdrrjv@vmst.io
2024-07-30

Very slick new use for the AVP

Mark, a 64-year old man with #AmyotrophicLateralSclerosis (#ALS), successfully used his direct thoughts to control the cursor on the #Apple #VisionPro when he played Solitaire, watched #AppleTV and sent text messages using the #Synchron brain computer interface, hands-free. Mark is otherwise unable to use the #AppleVisionPro due to the loss of function of his upper limbs. Apple Vision Pro requires hand gestures to make item selections.

iclarified.com/94435/apple-vis

joe•iuculano :mastodon:iuculano@masto.ai
2024-05-15

Via #CTV News

New research out of #London, Ont.’s #WesternUniversity is shedding light on a potential cure for #ALS, in which the targeting of the interaction between two proteins can halt or fully reverse the disease’s progression.

According to a news release from Western University on Monday, a team of researchers, led by Dr. #MichaelStrong, have discovered a potential path toward a cure for #AmyotrophicLateralSclerosis, also known as ALS

#Research #Medicine #Health

london.ctvnews.ca/western-univ

Western University researchers make breakthrough on possible ALS treatment
Researchers at Western University have made a discovery, showing that a protein can reverse, halt or prevent the death of motor neurons.
#globalnews #Health #ALS #AmyotrophicLateralSclerosis #Protein
globalnews.ca/news/10493114/we

Thiago Carvalhocyrilpedia@qoto.org
2023-04-26

The FDA has approved Biogen's ALS drug, Tofersen, an antisense oligo targeting SOD1. I wrote about this back in September in my Clinical Pipeline column as part of a shift towards approving drugs based on biomarkers without clear signs of clinical efficacy*.

nature.com/articles/d41591-022

*You can have a look at the trial data in NEJM, in a study that concluded that "In persons with SOD1 ALS, tofersen reduced concentrations of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks but did not improve clinical end points and was associated with adverse events."

lnkd.in/dwGMYGgh

#NatureMedicine #amyotrophiclateralsclerosis #drugdevelopment #pharma

2023-03-20

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology plos.io/3LB8ITH

2023-03-20

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology plos.io/3LB8ITH

2023-03-20

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology plos.io/3LB8ITH

Javier Díaz-NidoJavier_DN@red.niboe.info
2022-12-22

Study Traces Shared and Unique Cellular Hallmarks Found in 6 Neurodegenerative Diseases

Amyotrophic lateral sclerosis or Lou Gehrig’s disease, Alzheimer’s disease, Friedreich’s ataxia, frontotemporal dementia, Huntington’s disease and Parkinson’s disease harbor similar fundamental dysfunctional cellular processes.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Brain #ALS #AmyotrophicLateralSclerosis #FriedreichAtaxia #Ataxia #HD #Huntington #PD #Parkinson #FTD #FrontoTemporalDementia #Alzheimer

neurosciencenews.com/cellular-

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