`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1
#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain
In the fight against disease, programmed cell death – also known as #apoptosis – is a key protective function of the body. It breaks down cells that are damaged or have undergone dangerous changes.
#Biochemistry #sflorg
https://www.sflorg.com/2025/11/bchm11032501.html
.. promise in modulating numerous processes associated with #neurodegenerativediseases, #cancer, #epilepsy, and #traumaticbraininjury [Table 1]. In addition, the #ECS is known to influence #neuroplasticity, #apoptosis, #excitotoxicity, #neuroinflammation, and #cerebrovascularbreakdown associated with #stroke and #trauma.[105]
https://pmc.ncbi.nlm.nih.gov/articles/PMC5938896/
#WEEDMoB #Hanfgeschichten #hanf #hemp #marijuana
#Streeck 🙏 #NinaWarken 🙏
Herr #Merz #Söder #Klingbeil 😀 #Cannabis
![Phytocannabinoids CBD and Δ9-THC
In addition to the phytocannabinoid Δ9-THC, it is estimated that the cannabis plant consists of over 400 chemical entities, of which more than 60 of them are phytocannabinoid compounds. Some of these compounds have been identified as acting uniquely on both CB1 and CB2 receptors separately and simultaneously, and/or to inhibit or activate receptor functions. CBD, like Δ9-THC, is a major phytocannabinoid accounting for up to 40% of the plant's extract. CBD was first discovered in 1940 more than 20 years before Δ9-THC.[104,105] Until recently, Δ9-THC dominated cannabis research. All classes of phytocannabinoid compounds found in marijuana and hemp, including Δ9-THC and CBD, are derived from various changes to base molecular structure of cannabigerol-type compounds [Figure 1].[34,49]](https://files.mastodon.social/media_attachments/files/115/451/684/710/243/698/original/5232140f38ba5b8c.png)
Trying to think of a better phrase than "AI Bubble".
How about "AIpoptosis"?
Really depends on anything useful being left behind!
#AIBubble #apoptosis #AIpoptosis #AI
Wikipedia, Apoptosis
In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo a form of apoptosis that is genetically determined. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them.
Scientists Identify Potential Mechanism Behind Unnecessary Cell Death
Big win for cancer research, but messing with cell death sounds like a risky move.
Scientists Identify Potential Mechanism Behind Unnecessary Cell Death
Researchers have recently explored a fundamental question in cellular biology: why do some cells choose to die when it is not strictly necessary? In the human body, cells constantly make decisions that can mean life or death. Proper regulation of these decisions is critical, as mistakes can lead to ... [More info]
Scientists Identify Potential Mechanism Behind Unnecessary Cell Death
@aibot How might uncovering the specific biological pathways that trigger unnecessary apoptosis lead to revolutionary treatments in cancer therapy and other diseases, and what challenges do researchers face in manipul...
Integrated Manifestations of Cellular Stress as a Trigger of Tumor Progression - #cellularstress #stressfactors #intracellularorganelles #structuraldisorders #carcinogenesis #proliferation #invasion #metastasis #apoptosis #functionaldisorders #tumor #tumorprogression - https://link.springer.com/article/10.3103/S0095452725040048
Apoptosis, or programmed cell death, is an important process where cells kill themselves to keep the body healthy. It helps form organs, stops cancer, and involves complex steps like activating caspases. When this process goes wrong, it can lead to diseases like cancer or Alzheimer’s. #Apoptosis #cellbiology #biology #disease #wednesday #trending
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.
#EndogenousRetroviruses #ERVs #MusD #VirusLikeParticles #TopologicallyAssociatingDomains #Enhancers #LimbDevelopment #Apoptosis #Dactylaplasia
Wow, #cannabis has shown me w promise curing some cancers through #apoptosis, now they're finding it helps with others AND helps w/ chemo symptoms. #LegalizeIt ✊ so full scale research can investigate!
https://www.marijuanamoment.net/medical-marijuana-could-increase-efficacy-of-chemotherapy-to-fight-cancer-while-reducing-side-effects-study-suggests/
Grundlagenwissen ist kein Luxus – es ist die Basis jeder soliden Forschung. Deshalb nehmen wir uns im Team Zeit dafür – bewusst, regelmäßig, gemeinsam. #LehreImLabor #IF #IHC #Apoptosis #Zelltod #SevenichLab
Arecoline Hydrobromide Promotes the Apoptosis of Male Germ Cells - #arecolinehydrobromide #GC1cells #apoptosis #spermatogenesis - https://link.springer.com/article/10.3103/S0095452724050128
Caspases have well known roles in #apoptosis, but roles in other cellular processes are emerging... This study shows that #caspase -3 & -7 promote cytoprotective #autophagy in response to non-lethal stress by modulating PARP1 activity in #BreastCancer cells #plosbiology https://plos.io/41xfLVm
When it comes to boosting your #immunesystem, pumping up your intake of #fruitsandveggies is an important and relatively easy step. Likely, #VitaminC or ascorbic acid immediately comes to mind, and there’s a good reason for that. A recent study shows #ascorbicacid in the vitamin enhances natural killer cells or NK cells in people who recently underwent #chemotherapy. These #lymphocytes induce #apoptosis, the death of cancer cells. #angstromminerals #healthyfood
I'm extracting DNA from the legs of spiders which were euthanized by freezing in a household freezer. In almost every spider, the DNA shows a banding pattern associated with apoptosis. Why would there be so much programed cell death in the legs of spiders? Had it already happened naturally? Was it induced during the freezing process? I do not see this happening in other organisms using the same extraction procedure.
Each lane is DNA extracted from a different spider.
For #epithelial tissue homeostasis, cell elimination & proliferation must balance. @DaikiUmetsu &co show that faster cell removal is associated with switch from isolated to clustered #apoptosis, induced by ⬇️ #endocytosis & EGFR signaling #PLOSBiology https://plos.io/403rQ3Y
What are the effects of #centrosome amplification in #cancer? @basto_lab &co show that extra centrosomes prime #OvarianCancer cells for #apoptosis, acting in synergy with #chemotherapy to induce cell death, correlating with improved survival #PLOSBiology https://plos.io/4dbmpD7
Researchers examine #protein arrangement in #cell_membrane that triggers programmed cell death
#apoptosis #CD95_receptor #signalling #image_spectroscopy #microscopy
https://phys.org/news/2024-09-protein-cell-membrane-triggers-death.html
How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c
