Lmst

wow... crawling motility in Asgard #archaea!! www.biorxiv.org/content/10.1... look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...

Learn how dynein defects cause immotile cilia and recurrent infections.
#USMLE #Pathology #Cilia #GeneticDisorders #MedicalEducation

https://mymedschool.org/portfolio/u01-01-030-primary-ciliary-dyskinesia/?utm_source=mastodon&utm_medium=jetpack_social

Mammalian #cilia & #flagella depend on association of A- & B-tubules to form axonemal doublet #microtubules, but how? This study shows that CFAP77 is essential role for #axonemal connection of these tubules and crucial for #sperm motility & #fertility in mice @PLOSBiology plos.io/4ouZ2KJ

Overall architecture of sperm axonemal DMTs in Cfap77-KO mice. Top left: In-cell structural determination of sperm axonemal DMTs from Cfap77-KO mice. A cryo-EM map of DMTs with an 8 nm repeat was obtained by subtomogram analysis. The lost density (yellow colour) in sperm axonemal DMTs from Cfap77-KO mice was obtained by subtracting the density map of Cfap77-KO DMTs from that of the WT DMTs (EMD-35210/35211). The transverse sectional view of DMTs and the side view of the B-tubule lumen are shown. Bottom left: The atomic model of WT DMTs (PDB: 8I7O) fitted into the density map of Cfap77-KO DMTs. The Cfap77-KO DMTs presented a loss of density corresponding to the CFAP77-CCDC105-TEX43 subcomplex near protofilaments A11 and A12. Right: OJ-focused classification performed with good DMT particles. Red arrowheads mark the sites at which protofilament contacts are weakened or lost (A10–B01 and B01–B02).

15-Oct-2025
How #cilia choreograph their “Mexican wave”, enabling marine creatures to swim
New research has unravelled the mystery of how microscopic cilia coordinate to move and propel marine creatures through water.

https://www.eurekalert.org/news-releases/1101650

#science #biomechanics #MarineBiology

Thank you @bastinlab.bsky.social and Sylvie Friant for organising this amazing #cilia meeting! 🙏 So many interesting discussions, and not enough time! Just look at this beautiful venue... 🤩

RE: https://bsky.app/profile/did:plc:ixtxs3javtjrjba7egppzluq/post/3lgrzvju3nc2g

Complex behaviour is not limited to animals! Here we map the entire spectrum of waveforms dynamics on a quadriflagellate single cell with 4x 70um (!) #cilia, to a low dimensional behavioural manifold with surprising structure! #protistsonsky All revealed in our new preprint doi.org/10.1101/2025...

So you think you understand everything about #Chlamydomonas photoresponses? think again! #protists #behaviour #cilia To explain how Chlamy switches handedness from swimming in CCW circles in low-light to CW in high-light... see our new preprint led by Alan Tsang (HKU) 👇 doi.org/10.1101/2025...

Tiny projections on the surface of human cells can determine whether we stay healthy or develop a genetic disorder. Cell biologist Helen May-Simera is an expert on these hair-like structures called #cilia. Her research explores the impact these tiny components can have. Her work bridges fundamental molecular science with clinical relevance, direct patient engagement, and international teaching 👉 https://www.magazine.uni-mainz.de/the-big-impact-of-tiny-cell-structures/

#CellBiology #MolecularBiology #Biology #JGUMagazine #MainzUniversity

Professor Helen May-Simera conducts research in the field of molecular cell biology, in particular on ciliopathies. (photo/©: Peter Pulkowski / JGU)

Is it just me or is the larva doing its best impression of this emoji? 😊 #cilia

RE: https://bsky.app/profile/did:plc:5xukudukwpdj4d7dgyxfgfr4/post/3lu3laaby7du2

Happy to be involved in UNICIL, our new Wellcome Trust Discovery project coordinated by @micromotility.bsky.social

We will study ciliary dynamics across scales and organisms. A long-term #postdoc position will be available at Heidelberg University @uniheidelberg shortly.

@uniofexeter press release:

https://news.exeter.ac.uk/living-systems-institute/multi-million-project-to-crack-the-code-of-cilia-tiny-structures-with-big-impact-on-human-health/

#biology #microscopy #vEM #cilia #platynereis

scanning electron micrograph of a Platynereis larva showing a close-up of the prototroch ciliary band

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! 🎉🥂@lsiexeter.bsky.social news.exeter.ac.uk/living-syste...

Multi-million project to ‘crac...

Spatiotemporal analysis of >10 million #PrimaryCilia in 22 mouse #brain regions shows that #cilia have region-specific length & orientation patterns. #Circadian rhythms of cilia length suggest a role for cilia in the brain’s response to environmental changes @PLOSBiology https://plos.io/4lWnfbQ

Top left: Schematic Representation: (Top Left) Mice were perfused and harvested at two-hour intervals over a 24-h period. The harvested mice were then sectioned coronally. (Bottom Left) Coronal brain sections at different brain levels. (Top Middle) The ciliary base was defined as the origin of the coordinate system, and the tip of the cilia was labeled. Cilia length was measured from the base to the tips, and the circular angle was determined. (Bottom Middle) The brain section of the mice was divided into left and right hemispheres. For cilia found in the right hemisphere, a counter-clockwise coordinate system was used to determine the circular angle (Right). For cilia found in the left hemisphere, a clockwise coordinate system was used (Left). (Top Right) An example of the angle measurement from cilia found in the right hemisphere. Bottom left: Representative images of immunofluorescence staining showing cilia labeled with the ADCY3 antibody (red) and the basal body (cilia base) labeled with the centrin 1 antibody (green). Right: Brain Regions analyzed for cilia length and angle.

The four bundles of balancer #cilia showed coordinated beating and arrests, then re-beats, but the level of coordination was different between the two planes.

Kei then used a horizontal microscope and high-speed imaging to characterise the beating of balancer #cilia viewed from two orientations (along the tentacular and sagittal planes).

Schematic of the tilt microscope used to image ctenophores oriented with their balancer organ pointing upwards.

Something is brewing in the world of #cilia!!! So so excited for this... More details soon! 🎉🎉🍾🍾

RE: https://bsky.app/profile/did:plc:t5k64blscvqztybmmu2mlnuy/post/3lrsygrpf2c2o

I was the second talk of the meeting and wasn't even the first to mention #cilia! 😬 Why are pigs and lizards so weird... Okay quail is a cool system too...

Join us @ukcilianetwork.bsky.social annual meeting on Friday June 13th in London, featuring a special #cilia imaging/analysis session with Francesco Boselli (Durham), @bjwalker.bsky.social (UCL) and Beth Clarke (Imperial) Deadline for talk abstracts is tomorrow! www.ucl.ac.uk/child-health...

Researching for the @constant vitrine on #cilia. Trying to use as much as possible old electronics that were neatly stacked away in the microcontroller box. #permacomputing
(Permamicrocontrolling sounds a bit weird)

Here's a duemilanove with an Lcd, telling two times 16 character stories.

Blue Arduino Deumilanove microcontroller connected with a USB A cable. Red white and black wires are hooked up to an green tinted Lcd screen, where a squiggly line is shown. This line represents a Cilium, a haircell.

and behold the craziest of motile #cilia axonemes: 2500 microtubule doublets arranged in a double spiral. (of course from the sperm of some insect)

And now, a real treat... 😊 #cilia

#Cilia

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