📰 "Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations"
https://doi.org/doi:10.1016/j.xgen.2025.101033
https://pubmed.ncbi.nlm.nih.gov/41075790/
#DrosophilaMelanogaster
#Drosophila #Genomics

📰 "How to catch flies in the city (fast): Citizen Science on Drosophila ecology helps to raise awareness for biodiversity in urban environments"
https://www.biorxiv.org/content/10.1101/2025.10.10.681315v1?rss=1
#Drosophila

@mehranakhtar well done Mehran, very happy you had a great time there, pity I cannot come along! Look like CSHL treats you well #drosophila #sleep

@flypapers

A fascinating study, in fruit flies:

"Spreading depression (SD) is a wave of neuronal hyperactivity followed by depolarization block that propagates through large brain regions and is associated with disorders such as migraine, stroke, and brain injury."

"We show that rapid cooling, a naturally occurring environmental condition, as well as elevated extracellular potassium reliably elicit SD in both adult and larval flies."

#Drosophila #neuroscience

📰 "Population density triggers wing dimorphism via NlNompC-mediated insulin signaling in Nilaparvata lugens"
https://www.biorxiv.org/content/10.1101/2025.10.10.681384v1?rss=1
#Drosophila

📰 "Quantitative genetics of trauma induced mortality in Drosophila melanogaster"
https://www.biorxiv.org/content/10.1101/2025.10.09.681457v1?rss=1
#DrosophilaMelanogaster
#Metabolism #Drosophila #Genomics #Larva

📰 "Notch canonical activity in a subset of glial cells regulates short-term memory in Drosophila"
https://www.biorxiv.org/content/10.1101/2025.10.10.681599v1?rss=1
#Drosophila #Sleep

📰 "Whole brain fluorescence imaging in Drosophila reveals spreading depression and its initiation, propagation, and resilience dynamics."
https://www.biorxiv.org/content/10.1101/2025.10.09.681455v1?rss=1
#DrosophilaMelanogaster
#Drosophila #Adult
#Larva

📰 "The Drosophila OSC Genome: A Resource for Studies of Transposon and piRNA Biology"
https://www.biorxiv.org/content/10.1101/2025.10.09.681131v1?rss=1
#DrosophilaMelanogaster
#Drosophila #Genomics

📰 "Interactive effects of developmental and adult nutrition on lifespan and fecundity in a genetically diverse Drosophila population"
https://doi.org/doi:10.1371/journal.pone.0334341
https://pubmed.ncbi.nlm.nih.gov/41071844/
#DrosophilaMelanogaster
#Drosophila #Adult
#Larva

@thetransmitter

That's a massive big deal! Pins motor neuron degeneration on the lack of excitation supplied by its presynaptic interneurons rather than a problem intrinsic to the motor neurons themselves.

This is very much in agreement with findings in the fruit fly over a decade ago, where a key issue in a fly model for SMA (spinal muscular atrophy) is not in the motor neurons themselves but in the interneurons that synapse onto them and in the proprioceptive neurons that supply excitatory feedbacks.

"SMN Is Required for Sensory-Motor Circuit Function in Drosophila", Imlach et al. (McCabe lab) 2012.
http://dx.doi.org/10.1016/j.cell.2012.09.011

#neuroscience #SMA #SpinalMuscularAtrophy #Drosophila

📰 "Overwintering drives rapid adaptation in Drosophila with potential costs to insecticide resistance"
https://doi.org/doi:10.1093/evolut/qpaf205
https://pubmed.ncbi.nlm.nih.gov/41070988/
#DrosophilaMelanogaster
#Drosophila

📰 "Genetic architecture of the developing forelegs of Drosophila prolongata; an exaggerated weapon and ornament"
https://www.biorxiv.org/content/10.1101/2025.10.09.681446v1?rss=1
#Drosophila #Evolution

📰 "Regulation of Hippo signaling by Atrophin in the developing Drosophila wing"
https://www.biorxiv.org/content/10.1101/2025.10.09.681328v1?rss=1
#Drosophila #WingDisc

📰 "Translation regulation of ATF4 by the termination complex Hbs1-Pelo is required for visual system development and function"
https://www.biorxiv.org/content/10.1101/2025.10.08.681214v1?rss=1
#Drosophila

The much awaited connectome of the male central nervous system of the fruit fly, Drosophila melanogaster:

"Sexual dimorphism in the complete connectome of the Drosophila male central nervous system", Berg et al. 2025 https://www.biorxiv.org/content/10.1101/2025.10.09.680999v1

"contains 166,696 neurons spanning the brain and ventral nerve cord, fully proofread and comprehensively annotated including fruitless and doublesex expression and 11,691 cell types."

A collaboration between #HHMIJanelia, #MRCLMB and many others.

#neuroscience #connectomics #Drosophila

📰 "Insecticidal activity of the linear pseudoscorpion venom peptide Ammogarypin revealed by functional profiling"
https://doi.org/doi:10.3389/fphar.2025.1661173
https://pubmed.ncbi.nlm.nih.gov/41069607/
#Drosophila

📰 "Juvenile hormone mimics induce a cellular immune response in Drosophila melanogaster"
https://doi.org/doi:10.17912/micropub.biology.001797
https://pubmed.ncbi.nlm.nih.gov/41069492/
#DrosophilaMelanogaster
#Drosophila #Immunity #Larva

📰 "An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii"
https://doi.org/doi:10.1186/s12862-025-02450-3
https://pubmed.ncbi.nlm.nih.gov/41068562/
#DrosophilaMelanogaster
#Drosophila

📰 "Muscle derived BMP4 regulates morphology and function of endplates on extrafusal and intrafusal muscle fibers in adult mice"
https://doi.org/doi:10.1523/JNEUROSCI.0707-25.2025
https://pubmed.ncbi.nlm.nih.gov/41067921/
#Drosophila #Adult