Makes my day🙂 Graph ML identifies promising additional drug indications for diseases such as acute lymphoblastic leukemia and Alzheimer’s disease.
https://www.nature.com/articles/s41551-025-01598-z
#KnowledgeGraphs #GraphML #DrugRepurposing
#DrugRepurposing
Một dự án mới sử dụng AI kết hợp đồ tri thức để tái định vị công dụng của thuốc. Công cụ này giúp nhà nghiên cứu tìm ra thuốc cũ có thể trị bệnh mới, đồng thời hiển thị các bước luận giải một cách minh bạch. Dự án vẫn ở giai đoạn thử nghiệm.
#AI #DrugRepurposing #SideProject #HealthTech #Research #YKhoa #DuAnPhu #CongNgheSucKhoe #NghienCuu
🚀 Dự án phụ: công cụ khám phá tái sử dụng thuốc dựa trên AI giải thích được. Kết hợp knowledge graph và XAI để xếp hạng cặp thuốc‑bệnh, hiển thị đường dẫn lý luận (thuốc → mục tiêu → đường truyền → bệnh). Xây dựng bằng Python + React, hiện dùng dữ liệu mô phỏng. Mong nhận phản hồi về tính hữu ích, dữ liệu thực và cải tiến. #AI #DrugRepurposing #Research #SideProject #CôngNghệ #YHọc
Blood pressure drug, meet brain cancer. Scientists just uncovered how hydralazine “silences” glioblastoma cells, a 70-year-old medical mystery solved, and a ray of hope for patients. Is drug repurposing the future? Explore more at The Urban Herald!
https://theurb.co/hydralazine-brain-tumor-drug
#BrainCancer #Glioblastoma #CancerBreakthrough #MedicalInnovation #DrugRepurposing #CancerResearch #HealthNews #NeuroOncology #Hydralazine #ScienceExplained #News
Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
https://youtu.be/od0epKW19og
[13:03] hydroxyurea used to treat a person with POTS and MCAS
Here's an article on the topic:
Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9388361/
"First used 60 years ago for chronic myeloproliferative neoplasms, HU is now standard of care in reducing the severity of sickle cell disease (SCD) (McGann and Ware 2015). In this context, it is of interest that in animal models and human subjects with SCD, medications that reduce MC activation decreased bone pain (Vincent et al. 2013, 2016). HU also inhibits replication of human immunodeficiency virus-1 (HIV-1) and has been used in therapy of cyanotic congenital heart disease (Lori and Lisziewicz 2000; Reiss et al. 2007). A theoretic explanation for effectiveness of HU in these diseases include reducing MC activity independent of anti-proliferative effects. HU could decrease activity and ability of GI mucosal MCs that capture HIV-1 and mediate trans-infection of CD4 + T cells (Jiang et al. 2015). Similarly, HU could reduce the activity of the increased numbers of chymase-containing MCs in lung tissue of congenital heart disease patients and, thereby, decrease severity of these pulmonary and cardiac diseases (Hamada et al. 1999)."
The mechanisms are probably quite complex. One facet is that hydroxyurea increases fetal hemoglobin production and RBC membrane flexibility - which could increase O2 perfusion. Hypoxia activates mast cells.
#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology
💊 New in #DrugRepurposing Journal (Vol. 2, Issue 1):
"Role of Chemoinformatics & Machine Learning in Drug Repurposing"
From virtual screening & molecular docking to AI & AlphaFold — computational tools are transforming how we find new uses for old drugs.
📖 💊 New Issue Alert!
Drug Repurposing Vol 2, Issue 1 is out! 5 exciting articles explore AI, chemoinformatics, VR collaboration, and more — showing how existing drugs can find new therapeutic uses.
Genomica avanzata, terapie innovative ed intelligenza artificiale. La genetica italiana tra presente e futuro. Si terrà al Palacongressi di Rimini dal 23 al 25 settembre il XXVIII Congresso Nazionale della Società Italiana di Genetica Umana (SIGU) Come la genetica sta cambiando e sempre più cambierà la prevenzione e la cura delle malattie? Quali nuove frontiere stanno aprendo...
#CongressoNazionale #drugrepurposing #geneticaumana #Genomicaavanzata #oncogenetica #SIGU
A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229
lots of details on #pathophysiology in this review
#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
#WASF3
'RePo-SUDOE: A Transnational Network for Drug Repurposing in the SUDOE Space' - a new #DrugRepurposing article 💎 open access on #ScienceOpen 🔓📰
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGREPO.25.1.0004
#REPO4EU #RePoSUDOE #CancerResearch #SUDOE #TherapeuticTargets
My latest: Medicines Reimagined – #Repurposing Drugs For New Indications via @forbes https://www.forbes.com/sites/judystone/2025/08/27/medicines-reimagined--repurposing-drugs-for-new-indications/ #FDA #DrugRepurposing #MotorNeuronDisease #Malaria #RespiratoryPapilloma #HPV #Remedi4All #iDR25
📣🆕 Just in from #DrugRepurposing on #ScienceOpen:
'International Drug Repurposing Patent Landscaping, Part 3: Chronic Neurodegenerative Diseases 2010–2024'
🔓➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGREPO.25.1.0003
#REPO4EU #PatentLandscape #Neurodegeneration #Alzheimers #Parkinsons
📄 'Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer' - a DrugRxiv #Preprint on #ScienceOpen:
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGARXIV.PR000030.v1
#REPO4EU #DrugRepurposing #AnaplasticThyroidCancer #ExtracellularVesicles #Vandetanib #LiquidBiopsy
📖 An open community resource for #Preprints from the field of #DrugRepurposing — discover 'DrugRxiv' via #ScienceOpen 🌐⬇️ #REPO4EU
🔁📄 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
🔁📄 'Prioritizing repurposable drugs for Alzheimer's disease using network-based analysis with concurrent assessment of Long QT syndrome risk.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=c8f12215-0b3a-413c-bac7-ed5d27981865
#REPO4EU #NetworkMedicine #AlzheimersResearch #QTInterval #Interactome #Bioinformatics
🌐🔁 Advancing #DrugRepurposing for #PrecisionMedicine in Europe and beyond — explore Drug Repurposing Central via #ScienceOpen and browse over 10,000 publications in the Drug Repurposing Research Collection. #REPO4EU 🧬💊⤵️
https://drugrepocentral.scienceopen.com/collection/DrugRepoResearch
📢 New #OpenAccess article from the #REPO4EU #DrugRepurposing journal:
'MAPK8IP3-Related Neurodevelopmental Disorder: Case Report and Therapeutic Rationale for a Truncating Variant'
Live today on #ScienceOpen! ➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGREPO.25.1.0002
#️⃣ #RareDisease #PrecisionMedicine #Neurodevelopment #MAPK8IP3
Explore how interdisciplinary research and applied sciences work together to make successful #DrugRepurposing projects a reality — with the #OpenAccess 𝘋𝘳𝘶𝘨 𝘙𝘦𝘱𝘶𝘳𝘱𝘰𝘴𝘪𝘯𝘨 journal on #ScienceOpen. 🔁🧬💊 #REPO4EU
➡️ https://drugrepocentral.scienceopen.com/collection/DrugRepurposing
Explore over 10,000 #OpenAccessResearch publications on #DrugRepurposing in the REPO4EU 'Drug Repurposing Research Collection' on #ScienceOpen:
🔎 https://drugrepocentral.scienceopen.com/collection/DrugRepoResearch
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