Revealing novel #CD8+ T-cell #epitopes from the #H5N1 avian #influenza virus in HBW/B1 haplotype #ducks, https://etidiohnew.blogspot.com/2024/12/revealing-novel-cd8-t-cell-epitopes.html

#Epitopes in the #HA and #NA of #H5 and #H7 avian #influenza viruses that are important for #antigenic #drift, FEMS Microbiol Rev.: https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuae014/7670612?login=false

This review aims to compile the current information on haemagglutinin and #neuraminidase epitopes and immune escape mutants of H5 and H7 highly pathogenic avian influenza viruses.

Characteristics of #epitopes of limited variability on the head of #influenza #H1 #haemagglutinin http://biorxiv.org/cgi/content/short/2024.04.30.591841v1?rss=1

We conclude that the variability of an antibody binding site is determined by the number of variable residues included in its footprint rather than the intrinsic entropy of any particular region.

#Epitopes of an #antibody that neutralizes a wide range of #SARS-CoV-2 #variants in a conserved subdomain 1 of the #spike protein, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00416-24?af=R

Demonstrated identification of the neutralizing antibody that recognizes a conserved epitope implies basal contribution of such group of antibodies for #prophylaxis against #COVID19.

Multiplexed #CellularImaging. @DdJB_neuro @MohsenSadeghi &co label individual proteins with nanobarcodes comprising combinations of multiple #epitopes, allowing a normal 4-channel microscope to reveal identities of up to 15 different proteins #PLOSBiology https://plos.io/48bQ7G3

'#Bioprospecting' technique uncovers #viruses that can kill deadly superbugs.

#phages #antimicrobial #epitopes #porin

https://phys.org/news/2023-05-bioprospecting-technique-uncovers-viruses-deadly.html

New review from the Peters Lab at LJI: "T-cell epitope discovery and single-cell technologies to advance food allergy research"

As they write, "Advancements in single-cell T-cell receptor (TCR) sequencing in combination with transcriptome analysis provide exciting opportunities for identification and characterization of the TCR repertoires of allergen-specific T cells."

https://doi.org/10.1016/j.jaci.2022.10.025

#Tcells #FoodAllergy #Epitopes #Immunology #ImmuneSystem #CellularBiology #Genomics #OpenAccess

Hurray!

Eli Weinstein, @andrenguyen and myself got a contributed talk accepted at Winter Q-Bio! #winterqbio #qbio

Reach out if you'd like to hear about our work estimating the effects of mutations across the T cell receptor on epitope binding using observational data. The same sequence based methods generalize to a number of settings, including #antibodies.

#tcell #mutation #sequences #epitopes #epitopebinding #cdr #cdr3 #tcr #bcr