🧁 Tiny sugars in the brain disrupt emotional circuits, fueling depression
https://medicalxpress.com/news/2025-10-tiny-sugars-brain-disrupt-emotional.html
#brain #depression #mentalhealth #molbio #glycans #biology #neuroscience #emotions #psychology #psychiatry
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in everything from gene expression to cell survival. Learn about O-GlcNAc & more!
👉 https://research.bidmc.org/ncfg/blog/21-facts-about-intracellular-protein-glycosylation
#glycans #proteinmodification #glycosylation #posttranslationalmodification #cellbiology #science #glycotime
📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes. Check out the paper to see the interesting and surprising staining seen in different cells and tissues: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70172
The final session of Day 2 of #biocuration2025 is on glycans. Kiyoko Aoki-Kinoshita explains that the name for GlyTouCan (https://glytoucan.org) is a play on words in Japanese, where "Tou" means sugar!
Neurons Unplugged: A Fun Journey Through the Brain's Social Network!
#Neuroscience #BrainFunction #Neurons #Synaptogenesis #Glycans #GutHealth #Neurotransmission #BrainAdventure #ScienceFun #LearnWithMe #Neurites #Mitochondria #BrainHealth #CognitiveScience #EducationalVideo
SciTech Chronicles. . . . . . . . .Mar 26th, 2025
#xenoliths #volatiles #subduction #models #spike #glycans #receptor #low-mutation ##Yellowknife #linear #dodecane #SAM #lipids #Mesoscale #signature #transport #photolysis #replenishment #size #thickness
In the latest interesting facts about #glycans, we take a look at two tiny #glycolipids which are critical for life.
Read the full post at: https://research.bidmc.org/ncfg/blog/17-facts-about-two-tiny-glycolipids-essential-life
For more interesting facts: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
Novel #enzyme breaks down and synthesizes previously unexplored #glycans with prebiotic potential.
#mighymicrobes #Bacteroides #β-galactosidase #Bxy_22780 #α-GalF
https://phys.org/news/2025-03-enzyme-previously-unexplored-glycans-prebiotic.html
In our latest interesting fact about #glycans we take a look at the most abundant #glycoprotein found in #urine, and how its glycosylation and function varies under different genetic physiological conditions.
Read more at: https://research.bidmc.org/ncfg/blog/16-facts-about-major-glycoprotein-urine-uromodulintamm-horsfall-protein-thp
#Postdoc opportunity (2y) studying metabolism of #polysaccharides in brown #algae
in the Brown Algal #Glycans group at #Roscoff Marine Station🪸
https://emploi.cnrs.fr/Offres/CDD/UMR8227-CECHER-004/Default.aspx?lang=EN
Keyhole Limpet Hemocyanin (KLH) is used to produce #antibodies and as an #immunostimulant. Interestingly 3-4% of it's weight is #carbohydrate.
In this month's interesting facts about #glycans we take a look at the unusual #glycosylation of KLH.
Read at: https://research.bidmc.org/ncfg/blog/facts-about-keyhole-limpet-hemocyanin-klh-and-its-unusual-glycosylation
Want to know where #glycans are specifically expressed in the #brain? Using smart anti-glycan reagents (SAGRs) we map the specific expression of glycans in the mouse brain. Check out poster-150 presented by Dr. Ea Tulin at the 2024 Society for Glycobiology meeting!
In this month's interesting facts we take a look at CMP-Sialic acid, a sugar donor which is key in the #sialylation of #glycans; and its synthetase.
Read more: https://research.bidmc.org/ncfg/blog/facts-about-cmp-sialic-acid-nature
For more interesting facts: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
Glycoproteins and longevity: an interview with Professor Gordan Lauc
https://doi.org/10.1080/14728222.2024.2375809
#aging #longevity #glycobiology #immunology #biomarkers #inflammation #IgG #glycoproteins #glycans
In this month's interesting facts about #glycans we look at the #glycoprotein collagen and its unique #glycosylation
Read the post: https://research.bidmc.org/ncfg/blog/facts-about-collagen-and-its-glycosylation-one-most-common-glycoproteins-all-animals
For more interesting facts check: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
It is the prerogative of the young to ignore the humble efforts of the old. Nevertheless, I can feel a slight sting: https://doi.org/10.1038/s41592-024-02314-6 vs. https://doi.org/10.1109/TCBB.2010.129
Turns out, I made a complete chapter out of that, in my "will-be-finished-soon-or-possibly-never" "textbook", https://bio.informatik.uni-jena.de/textbook-algoms/. Sigh... Their program name is dope, though. #glycans #massspectrometry
A single #mutation in dairy #cow-associated #H5N1 viruses increases #receptor #binding breadth, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.06.22.600211v1
We found that H5 from A/Texas/37/2024, an isolate from the dairy cow #outbreak, has increased binding breadth to #glycans bearing terminal a2,3 sialic acids, the avian receptor, compared to historical and recent 2.3.4.4b H5N1 viruses. We did not observe any binding to a2,6 sialic acids, the receptor used by human seasonal influenza viruses.
"These dynamic #proteins indicate a variety of binding capabilities, and we confirm that one mosaic adhesive trimer (MAT) member shows specificity for surface #glycans from a particular prey. Our study shows that the B. #bacteriovorus MAT protein repertoire enables a broad means for the recognition and handling of diverse prey epitopes encountered during #bacterial #predation and invasion."
This month on our blog - we highlight interesting facts about Pectin - One of the Most Complex Polysaccharides in Nature and its Healing Properties.
For more interesting facts about glycans check out our page: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
In our final podcast episode of 2023, Dr. Michael Demetriou shares his research targeting cell surface sugars to develop new therapies for multiple sclerosis and cancer, life outside the lab, and more!
https://peoplebehindthescience.com/dr-michael-demetriou/
#science #biology #podcast #podcasts #STEM #multiplesclerosis #cancer #cancerresearch #glycobiology #glycans #chemistry #biochemistry #scicomm
