New Approach To Stopping Diabetic Blood Vessel Damage: An enzyme inhibitor drug stops vessel lining damage in the retina, kidneys, and other sites. #diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol
https://www.instagram.com/p/C3Gd8J9LAmk/

@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!

Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?

Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

Laura Hartmann ist seit 1. März 2023 Professorin für #MakromolekulareChemie. Ein Schwerpunkt ihrer Professur liegt auf der Erforschung aktiver weicher Materie, insbesondere sogenannter biomimetischer #Polymere.
Hartmann hat soeben einen Consolidator Grant des Europäischen Forschungsrats (ERC) erhalten. Die EU fördert damit ihre Forschung zur #Glycocalyx, der Zuckerschicht auf menschlichen Zellen.
http://uni-freiburg.link/hartmann-laura

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)