How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

old but interesting research article [2017]:

Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC5541866/

"Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed."

#biology #biochemistry #heme #RBCs #glycine #anemia

Creation of Heme and Hemoglobin Producers Based on Microorganisms - #Heme #leghemoglobin #hemoglobin #synthesis #geneticallymodifiedorganisms #GMO - https://link.springer.com/article/10.3103/S009545272404008X

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

#Heme biosynthesis #Angigoenesis

Roles of #EndothelialCell FLVCR1a, a heme exporter to extracellular space in
✅Developmental Angiogenesis-🐭Retina🐟ISV
✅Tumor angiogenesis
❎Vascular homeostasis

Dr. Sara Petrillo lab Angiogenesis 2023
https://link.springer.com/article/10.1007/s10456-023-09865-w

FLVCR1a deficiency-> #EndothelialCell-autonomous defects in Mitochondria, ER stress & Angiogenic behaviors

Heme accumulation triggers #Paraptosis (Organelle swelling-> Cytoplasic vacuolation)💀

Dr. Emanuela Tolosano lab Cell Death Diff 2018
https://www.nature.com/articles/s41418-017-0001-7

Other enzymes in Heme metabolism in #Angiogensis👇

Ferrochelatase is a therapeutic target for ocular neovascularization
https://www.embopress.org/doi/full/10.15252/emmm.201606561

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7

Dem gibt es nichts hinzuzufügen. #spreewald #mundart #heme

Hi @DNPFred
In grad school I worked on heme proteins using #paramagnetic #NMR and #NRVS. Then I shifted to #XRayCrystallography, using #EPR #UVVis and #EDX on #crystals when a postdoc. My research group works on #NonHemeIron #enzymes, & #heme, #copper & #manganese #metalloproteins. Really interested in combining #spectroscopy on #protein #crystals to examine #structure #function relationships.

Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that

"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."

#Chemotherapy #doxorubicin #mitochondria #heme

https://www.science.org/doi/10.1126/scisignal.abn8017?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial