#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0
#InnateImmunity
New study! Learning about inflammation by studying the differences between mammals – a toot-orial.
https://doi.org/10.1186/s10020-024-01052-x
When the body meets an infectious microbe or similar challenge it activates an inflammatory cascade. Inflammation helps eliminate the microbe, but, if it gets of control, it can be dangerous or even fatal.
We like to assume that inflammation is basically the same for all animals. And this is usually true in cell culture, but in vivo …
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@cyrilpedia Together with the organ-specific composition of the #innateimmunity cellular mix, there is still a vast landscape that needs our attention. Why does the dynamic of #autoimmunity or #antitumoral show such a great organ-specific diversity...? And not only on the T cell repertoire... @gpollara @scholpp_lab
'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor
'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1
'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext
'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7
'Distinct patterns emerge when comparing sustained and transient infections. Transiently infected participants have a robust type of antiviral defence response termed a type I interferon (IFN-I) response in the nasal mucosal tissue shortly after viral exposure (day 1 after infection), potentially contributing to viral removal. By contrast, participants who had sustained infection showed delayed (only starting on day 5 after infection) mucosal IFN-I responses, as well as delays in immune-cell infiltration into the nasopharynx, indicating an impaired innate antiviral response at the site of initial viral inoculation and replication.'
#Covid #Covid19 #Immunology #Virology #InnateImmunity
'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.'
#Preprint #Immunology #InnateImmunity #Interferon
Unveiling the Mighty Shield: Exploring the Marvels of Innate Immunity
#BodyDefenseMechanism, #ImmunologicalReaction, #InbornImmunity, #InnateImmunity #Immunology Introduction In the ongoing battle between the human body and invading pathogens, the first line of defense is often the…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
Understanding Innate Immunity in Humans: The First Line of Defense
#ImmuneSystem, #Immunity, #InnateImmuneSystem, #InnateImmunity #Immunology Introduction Innate immunity is the body’s initial, rapid, and non-specific defense mechanism against invading pathogens. It is an ancient and…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
This is a really great overview of innate immunity concepts across organisms. A really fantastic conceptual read and one that I may add to my "required reading" list for training new students/lab members in concepts of innate immunity.
https://www.cell.com/immunity/fulltext/S1074-7613(24)00128-6
#Drosophila #Celegans #HostPathogen #Immunology #InnateImmunity
⏰ There's less than a month left to submit your abstract for #EESImmunity! Will you be one of the 20+ speakers selected from abstracts? Don't miss your chance 💪
Join leading experts in immunology, microbiology, and cell biology to discuss recent progress in their understanding of host-pathogen interactions 🦠🧫
💻 https://s.embl.org/ees24-08
✍️ Submit your abstract by 26 March
📅 18 – 21 June
#innateimmunity #cellautonomousimmunity #hostpathogeninteractions #infectionbiology
@chfloudas @cyrilpedia @gpollara certainly worth the time! #nkcell #cancer_research #immunology #innateimmunity
https://www.nature.com/articles/s41579-022-00846-2
Long COVID: major findings, mechanisms and recommendations
https://www.sciencedirect.com/science/article/pii/S2589004223011719
Impact of peripheral mitochondrial DNA level on immune response after COVID-19 vaccination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474411/
Common mitochondrial haplogroups as modifiers of the onset-age for critical COVID-19
#COVID19 #LongCovid #mitochondria #mtDNA #Haplogroup #InnateImmuneMemory #InnateImmunity
"In the present study, we show that adult Drosophila melanogaster fed high-sugar diets became more susceptible to infection by the Gram-negative bacteria Providencia rettgeri and Serratia marcescens, although diet had no significant effect on infection by Gram-positive bacteria Enterococcus faecalis or Lactococcus lactis."
#Preprint #Immunity #Metabolism #InnateImmunity #Drosophila
Your immune system has two branches that help you fight infection! Learn how these two branches help keep you healthy, and other information about how your immune system works, at immunologyexplained.org.
#ImmunologyExplained #Immunology #ImmuneSystem #InnateImmunity
"Human cells express TRIM5α that restricts HIV-1. HIV-1 M evolved to escape this restriction by binding cyclophilin A (CYPA) to the viral core. Our data indicate that nonpandemic HIV-1s are sensitive to human TRIM5α."
#HIV #immunology #InnateImmunity
#innateimmunity in action: #immunotherapy against #breastcancer with TLR3 ligand and interferon alpha. Only six patients in this #trial , but biopsy analyses show improved #inmuneinfiltration with #TILs and is linked to clinical observations. #interferon #cytokines #immunology #macrophages @chfloudas
https://jitc.bmj.com/content/11/11/e007381
Interleukin-1 is involved in #inflammation but the role in #cancer is not so clear...and here is a new insight for #pancreaticcancer : a loop between tumour cells and interleukin-1β-expressing #tumor associated #macrophages is supporting the tumor, this being brought on by a synergy between prostaglandin E2 (PGE2) and tumour necrosis factor (TNF), also opening the door for translational interventions #immunotherapy #innateimmunity #Immunology @cyrilpedia @gpollara
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