mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity.

#RNA #mRNA #3UTR #IntrinsicallyDisorderedRegions #IDRs #IntrinsicallyDisorderedProteins #Chaperones #Preprint

https://www.biorxiv.org/content/10.1101/2025.07.02.662873v1

🧠 How do prediction models perform in recognizing disordered regions with specific binding functions?

🔗 Evaluation of predictions of disordered binding regions in the CAID2 experiment. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.009

📚 CSBJ: https://www.csbj.org/

#Bioinformatics #ProteinDisorder #CAID2 #IntrinsicallyDisorderedProteins #LigandBinding #ComputationalBiology #AIinScience #DeepLearning #MolecularBiology

6-Mar-2025
A new algorithm sheds light on ‘disordered’ #proteins

The #IntrinsicallyDisorderedProteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making #structurePrediction particularly challenging. These proteins although exhibit chaotic and ‘disordered’ structures, they still perform essential functions.
https://www.eurekalert.org/news-releases/1075837 #science

Reliable analysis of #IntrinsicallyDisorderedProteins: Researchers of #MainzUniversity and EMBL Hamburg present new approach to determine form of disordered proteins by using two different methods simultaneously in a single sample https://press.uni-mainz.de/reliable-analysis-of-intrinsically-disordered-proteins/
https://nachrichten.idw-online.de/2025/01/20/reliable-analysis-of-intrinsically-disordered-proteins

Reliable analysis of #IntrinsicallyDisorderedProteins: Researchers of #MainzUniversity and the European Molecular Biology Laboratory (EMBL) in Hamburg present a new approach to determine the form of disordered proteins by using two different methods simultaneously in a single sample 👉 https://press.uni-mainz.de/reliable-analysis-of-intrinsically-disordered-proteins/ #biophysics #MolecularBiology #SyntheticBiology #proteins #biocondensates

13-JUN-2024
Developing a system to study proteins without fixed structures
Researchers propose a novel pipeline that makes the analysis of intrinsically disordered proteins much faster and more convenient

I do love #IntrinsicallyDisorderedProteins but pinning them down to do a crystal structure is kind of against the spirit? NMR structures giving dynamic representations have served the field well

https://www.eurekalert.org/news-releases/1048185 #science #proteins #structuralBiology #IntrinsicDisorder

4-JAN-2024
Scientists tame chaotic protein fueling 75% of cancers
Discovery opens window to more effective treatment

https://www.eurekalert.org/news-releases/1030250 #science #nanoworld #IntrinsicallyDisorderedProteins #myc #cancer #proteins #ProteinFolding