Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70077?af=R
#IonChannels
The molecular transition that confers voltage dependence to muscle contraction | Nature Communications https://www.nature.com/articles/s41467-025-59649-7
#ionchannels
Identification of druggable binding sites and small molecules as modulators of TMC1 | Communications Biology
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature
#ionchannels
Nicotinic acetylcholine receptor #ionchannels regulate growth hormone in pituitary somatotrophs
…in tigers…
Preferential allosteric modulation of Otop1 channels by small molecule compounds | Communications Biology
#ionchannels
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications
#ionchannels
Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation | Cell Death & Disease
#ionchannels
Cambridge-based Maxion Therapeutics raises €68.9 million in Series A funding led by General Catalyst to advance its KnotBody pipeline targeting ion channel and GPCR-driven diseases.Maxion Therapeutics, a Cambridge-based biotech firm, has raised €68.9 million in a Series A funding round led by General Catalyst. #biotech #drugdevelopment #funding #GPCR #ionchannels
HCN4 channels sense temperature and determine heart rate responses to heat | Nature Communications
#ionchannels
Ball-and-chain inactivation of a human large conductance calcium-activated potassium #ionchannels
Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannels
Understanding the role of mutations in voltage-gated sodium #ionchannels for cardiovascular disorders | Journal of General Physiology | Rockefeller University Press https://rupress.org/jgp/article/157/2/e202413744/277228/Understanding-the-role-of-mutations-in-voltage
Inactivation of CaV1 and CaV2 #ionchannels | Journal of General Physiology https://rupress.org/jgp/article/157/2/e202313531/277243/Inactivation-of-CaV1-and-CaV2-channelsInactivation
α‐Adrenoreceptor blocker phentolamine inhibits voltage‐gated sodium #Ionchannels via the local anaesthetic binding site - Toklucu - British Journal of Pharmacology https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17450?af=R
Ethosuximide: Subunit‐ and Gβγ‐dependent blocker and reporter of allosteric changes in GIRK #ionchannels - Shalomov - British Journal of Pharmacology https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17446?af=R
Nociceptor sodium #ionchannels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology @JGenPhysiol https://rupress.org/jgp/article/157/2/e202313526/277223/Nociceptor-sodium-channels-shape-subthreshold
Previously broken link!🤯
Fully Funded BBSRC DTP Studentship on #IonChannels using patch clamp, stem cells, artificial intelligence and modelling.
Proper link here. I hope
Identification of a binding site for small molecule inhibitors targeting human TRPM4 #ionchannels | Nature Communications https://www.nature.com/articles/s41467-025-56131-2
Thermo‐TRP #ionchannels regulation by endogenous factors and its physiological function at core body temperature - Kashio - 2025 - Physiological Reports - Wiley Online Library https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70164?af=R
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