#JAXLEY

Fabrizio Musacchiopixeltracker@sigmoid.social
2025-11-14

🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

🌍 doi.org/10.1038/s41592-025-028

#Neuroscience #CompNeuro

Fig. 1: Differentiable simulation enables training biophysical neuron models.

Client Info

Server: https://mastodon.social
Version: 2025.07
Repository: https://github.com/cyevgeniy/lmst