KDM6A depletion in breast epithelial cells leads to reduced sensitivity to anticancer agents and increased TGF-β activity. https://doi.org/10.1158/1541-7786.MCR-21-0402 #Kdm6a #DrugResistance #TgfΒ

Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub

We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!

#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!

#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm