#Neutralization of #SARS-CoV-2 #KP1, #KP11, #KP2 and #KP3 by #human and murine #sera
Source: npj Vaccines, AbstractWe report SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 neutralizing antibody titers. They displayed increased immune evasion compared to JN.1, especially KP.1 and KP.3, for participants who experienced BF.7/BA.5.2 breakthrough infection or received bivalent (delta/BA.5) vaccine boosting. Second XBB sub-variants breakthrough infection enhanced the neutralization…
#Escape of #SARS-CoV-2 #variants #KP11, #LB1 and #KP33 from approved #mAbs http://biorxiv.org/cgi/content/short/2024.08.20.608835v1?rss=1
#Sipavibart neutralized JN.1.1 but lost antiviral efficacy against KP1.1, LB.1 and KP3.3. Our results highlight the need for a close clinical monitoring of Pemivibart and raise concerns about the clinical efficacy of Sipavibart.
Nuevas #variantes de #covid19 circulan en #Guatemala https://boletinaldia.sld.cu/aldia/2024/07/27/nuevas-variantes-de-covid-19-circulan-en-guatemala/
La cartera sanitaria refirió un reciente informe de la dirección del Laboratorio Nacional que confirmó por primera vez las cepas #KP y sus sublinajes #KP11, #KP113, #KP2, #KP22, #KP23, #KP323.
FLiRT COVID-19 Variants Are Spreading: What to Know About KP.2 and KP.1.1 Strains | prevention.com
"The current COVID vaccine may not protect against them as well as previous variants."
#COVID19 #KP2 #KP11 @auscovid19
Source: https://www.prevention.com/health/health-conditions/a60701402/flirt-new-covid-variants/
Update for 3/25/2024!
Good morning SARS2PAians!
Hope you're enjoying a healthy start to this chilly Spring 💐
Sorry I didn't mirror the Friday Reddit post here on Fedi but it IS there to view.: https://old.reddit.com/r/SARS2PA/comments/1bl0z7v/3222024vocs_wastewater/
There's no new wastewater metrics today.
__________
VOCs
So far, the variant leaderboard is holding steady. The KP.x.y clan has not made any significant leaps during the past few days.: https://ibb.co/NtcKCyG
__________
CDC
Lots of new hospital admits in the northern half of the State, from Pike Co on over to Jefferson and up to Potter.: https://ibb.co/Pjrqqwr
The staffed inpatient beds map looks really GOOD! There are NO COUNTIES with increases!! 😎: https://ibb.co/jMysDnG
Unfortunately, there are many counties with ICU increases, the southwest corner from Washington Co up to Blair, and also McKean, Potter and Cameron in the northwest.: https://ibb.co/kgpGVFw
__________
Research
Wastewater Research
Dr. Eric Topol wrote on Mastodon:
"First evidence indicating the JN.1 variant (and BA.2.86) are linked to higher fecal shedding than prior SARSCoV2 variants": https://ibb.co/jLXsMqY
https://thelancet.com/journals/laninf/article/PIIS1473-3099(24)00155-5/fulltext
__________
Long COVID research
There has been some success in Malta to find the reason for Long Covid. Seems that since COVID attaches by means of ACE2 binding, the body reduces ACE2 in reaction to control the viral infection.
https://www.eurekalert.org/news-releases/998736
When the body reduces ACE2 levels, it shuts itself closed like a door to make COVID entry less possible...but this also results in extreme fatigue when trying to move around, use muscles, exercise, etc.
This could be a basic explanation why in particular, atheletes are especailly keen on experiencing disabling reactions to COVID infection.
There are also antibodies in our own system that attack ACE2, and long aggravation of these antibodies can cause autoimmune disability similar to multiple sclerosis.
Twitter link: https://twitter.com/citrusdriad/status/1772040141789434035
:ms_arrow_right: Reminder: FluA, FluB, and the extremely contagious gastro pathogens Norovirus and Rotavirus are still considered HIGH according to WastewaterSCAN. PLEASE wash those hands with soap and warm water for 20sec, wash fruits and veg, and do not handle food if you are sick!!
I hope we continue to see the levels for all these pathogens fall to hisorically low levels. Some common sense source control will prevent life, learning, and irreplaceable financial loss!
Have a great week, PA ❤️️ :catjam:
#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #JN1 #FluA #FluB #Influenza #Norovirus #Noro #Rotavirus #LongCOVID
#KP1One #KP11
#KP2
#KP2One #KP21
Good Afternoon SARS2PAians!!
I hope your stuff stayed in place with all that wind out there!
There's no new wastewater data today.
Lineage News
JN.1.x.y continues to dominate the national leaderboard.
There are a few variants to watch for future activity, including KQ.1, KP.2, KP.1.1 and KR.1, all grandchildren of JN.1.: https://ibb.co/j800SF3
JN.1.16 is also proving pretty darn fast. Pennsylvania already has had samples of JN.1.16 submitted.: https://ibb.co/qdDB3qF
Some of them have already gotten "above the fold" nationally. KP.2 and KP.1.1 are already in the top half of variants. JN.1.11.1 is still around at sizeable levels.: https://ibb.co/zSnSp9N
XDP is a recombination of JN.1.4 and FL.15 (descendant of XBB.1.9.1).
__________
CDC
In spite of lower infection numbers, there seems to have been a lot of emergency cases filtering through the medical system since last update.
New Hospital Admits substantially increased in Central PA from Lycoming Co. aaaaall the way over to Venango Co., and also from York on the southern border to Fulton Co.: https://ibb.co/FqJQtfS
Staffed inpatient beds steady through the State except for Lawrence and around McKean Cos.: https://ibb.co/ZGzv578
ICU bed use increased significantly in Lawrence, in Vanango aaaaaalll on up to the northern border and over to Tioga, and around Luzerne Co.: https://ibb.co/7N3Tzq5
CDC At-a-Glance has test positivity, hospital admits, ED visits and deaths trending stradily downward so far though.: https://ibb.co/x3MtrNP
__________
Non-SARS2 stuff
SARS2 has actually been downgraded on WastewaterSCAN to "medium" spread!: https://ibb.co/Cz4PQmk
NonSARS2 pathogens are still just demolishing us.
Most respiratory stuff is still high except COVID/SARS2. RSV, FluA, FluB, are all HIGH still. Parainfluenza is now HIGH.
The gastro stuff, Norovirus and Rotavirus, is still crazy HIGH. Noro is still rising in Chester Co.
:ms_arrow_right: Noro is very resistant to heat and hand sanitizer! You MUST wash hands with warm water and soap for 20 seconds to reduce your chances of spreading noro! :catjam:
That's all I have for this week, PA. Keep close watch of that air quality and wash hands so we can have an AWESOME and healthy Spring! 💐💐💐
#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #JN1 #FluA #FluB #Influenza #Norovirus #Noro #Rotavirus
#JN1Sixteen #JN116
#KP1One #KP11
#KP2
#KP2One #KP21
#WearAMask #CleanTheAir #VaccinesSaveLives #WashHands #Wastewater #StayHomeIfSick #SourceControl #USESourceControl #COVIDSourceControl
Update for 3/8/2024!
Good Morning SARS2PAiains!!
I hope you're ready for that time change on Sunday! 🕐🕐🕐
This is a wonderfully short update. I mean, it doesn't look short, but it kinda is. 🤪
There's no new CDC stuff.
There are no new wastewater updates and we are continuing to approach lower levels of previous years as spring gets closer.: https://ibb.co/QfPr8NJ
__________
Lineage News
There's no new immediate variant news as JN.1 is still the only thing all over the place so far.
There are some new varaints being watched as JN.1 (and specifically JN.1.11) seems really capable of producing descendants that worry virologists:
❗️JN.1.16: Concerningly infectious even over very wide areas in China; Lots of this currently being uploaded from what I gather in USA too, already in 9 states.
❗KP.1.1 (which is JN.1.11.1.1.1): this has a potential nuts-level of growth rate going by genetics alone.
❗KP.2 (which is JN.1.11.1.2): seems closely related to JN.1.16 that I was, in my very very unprofessional opinion, concerned about last update.
❗KP.2.1: widespread already in East Asia.
KP.x.y has an extraordinary growth rate only considering mutations but we'll see how any of this checks out in actual biological results.
__________
NON SARS PATHOGENS
There is still a very high amount of total pathogens all around.: https://ibb.co/3sxWQ3C
Respiratory pathogens are still high according to WastewaterSCAN:
❗SARS2
❗RSV
❗Flu A
❗Flu B
❗Parainfluenza, which has been upgraded to HIGH since last update.
Gastro stuff is still very high too!:
❗Norovirus
❗Rotavirus
Noro is thankfully declining at UPark but still in the very high range.: https://ibb.co/CMSGsjg
If we keep using common sense ways to control it, it prevents DAYS of learning/financial loss and potential hospital visits for dehydration. And...it's just gross to deal with. 🤢
Fpr respiratory illnesses, wear a quality respirator, be aware of social contacts, mask/respirator up in crowds and in low ventilation areas (low ceilings, restrooms, elevators, etc.), keep the air clean, get those COVID and flu shots, and STAY HOME if you are sick!
For the gastro stuff, don't prepare food when sick. Don't depend on gloves for sanitizing either! Wash fruits and veg before you eat them.
Wash hands with soap and water for 20 seconds.
❗Hand sanitizer and heat does not work well against Norovirus because the individual virions are very very tough to kill. You MUST wash hands with soap and water.
For all pathogens, cover coughs and sneezes in the elbow crease and not your hands.
We're almost there! :canparrot:
It's Goose flyover season! :cangoose:
We're gonna have a great Spring, and simple, common sense consideration and source control is how we get there! 💐💐💐
#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #JN1 #FluA #FluB #Influenza #Norovirus #Noro #Rotavirus
#JN1Sixteen #JN116
#KP1One #KP11
#KP2
#KP2One #KP21
#WearAMask #CleanTheAir #VaccinesSaveLives #WashHands #Wastewater #StayHomeIfSick #SourceControl #USESourceControl #COVIDSourceControl
