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#MolecularGenetics

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-07-03

Global genetic interaction map of human cell reveals conserved principles of genetic networks
biorxiv.org/content/10.1101/20

Global genetic interaction map of human cell reveals conserved principles of genetic networks https://www.biorxiv.org/content/10.1101/2025.06.30.662193v1?rss=1 #interactome #MolecularGenetics #genetics #FunctionalGenetics
Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-06-27

The Talented Dr. Snyder. Massive biomolecular shifts occur in our 40s/60s
med.stanford.edu/news/all-news

Nonlinear dynamics of multi-omics profiles in human aging
nature.com/articles/s43587-024
news.ycombinator.com/item?id=4

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-06-27

AlphaGenome: AI for better understanding the genome - Google DeepMind
deepmind.google/discover/blog/
news.ycombinator.com/item?id=4

Comment: even in well-studied organisms (E. coli; yeast: Saccharomyces; minimal synthetic cells ...) the function of a staggering number of essential genes is unknown.

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-04-02

[biological evolution] Whole-genome duplication drives long-term adaptation
sciencedaily.com/releases/2025
news.ycombinator.com/item?id=4

Genome duplication in a long-term multicellularity evolution experiment
nature.com/articles/s41586-025

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-03-21

Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
sciencedaily.com/releases/2025
le.ac.uk/news/2025/march/dna-h

* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material

Structural dynamics of DNA unwinding by a replicative helicase
nature.com/articles/s41586-025

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2025-02-04

Mitochondria as youโ€™ve never seen them
nature.com/immersive/d41586-02
news.ycombinator.com/item?id=4

Comments
me: former mitochondrial (mt) researcher, published
mt difficult to prepare/isolate intact/pure
extraordinary imagery shows why

Yet another "illustration" ๐Ÿ˜‰ of crit imp. of fundamental research

niehs.nih.gov/research/atniehs
tools.niehs.nih.gov/polg/ --> mt. diseases ...
en.wikipedia.org/wiki/Mitochon

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2024-11-04

Top 10 discoveries about ancient people from DNA in 2023
johnhawks.net/weblog/the-top-1
news.ycombinator.com/item?id=4

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2024-08-29

Prevalence of Problematic Papers in Non-Coding RNA Research
biorxiv.org/content/10.1101/20

* prevalence of problematic papers in field of non-coding RNA (ncRNA) research
* 1.79% retracted; 5.68% raised concerns on PubPeer
* unreliable papers widely disseminated
* hundreds of thousands citations
* significant threat to research integrity / public health

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2024-08-21

Nonlinear dynamics of multi-omics profiles during human aging
nature.com/articles/s43587-024

* Stanford; Mike Snyder well-known
* aging a complex process associated w. nearly all diseases (aging-related diseases)
* understanding molecular changes underlying aging
* consistent nonlinear patterns in molecular markers of aging
* substantial dysregulation at two major periods occurring at ~44โ€‰& ~60โ€‰years chronological age
* distinct molecules, functional pathways

HollyHollyCo26588808@universeodon.com
2024-07-08

#stem #Science #health #immunology #moleculargenetics #spiffy #Texas

THX 1 created. Only 1137 to go

medicalxpress.com/news/2024-07

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2024-06-20

Grolar bear hybrids in N.W.T. all traced back to same 'strange' female polar bear
New genetic sequencing tool shows family of western Arctic hybrids are 'quite rare'
cbc.ca/news/canada/north/polar

Development of an 8K SNP chip to assess adaptive diversity and hybridization in polar bears
link.springer.com/article/10.1

UrsusMaritimus

Rageelarageela
2024-04-25

Unlocking the secrets of life, one strand at a time! Happy National DNA Day! ๐Ÿงฌ

Jenny Wu ้‚ฌ็ๅฆฎ ๐Ÿ‡บ๐Ÿ‡ธ๐Ÿ‡บ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€๐ŸŒˆ๐Ÿณ๏ธโ€โšง๏ธ๐ŸŒนโœŠ๐Ÿพjenny_wu@1234.as
2023-12-19

@admitsWrongIfProven

Also I started posting page by page commentary a while back, on The Seven #Daughters of #Eve by Professor Brian Sykes. #molecularBiology #molecularGenetics #BioInformatics #girlPower

1234.as/@jenny_wu/109686480388

Retoots plz?

T R Shankar Raman (has moved)mizoraman
2023-09-30

A remarkable book on many of 's most remarkable and the challenges these women have faced and surmounted in research and . From to , to and to .

cntraveller.in/story/the-stori

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2023-09-08

Addendum 2

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation
biorxiv.org/content/10.1101/20

* tardigrades survive doses of ionizing radiation 1000x human lethal dose
* specific, robust response to ionizing radiation
* irradiation induces rapid dramatic upregulation of DNA repair genes

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2023-07-07

This, Science magazine 2016, is older (still an incredible achievement) but recent discussion:

Design and synthesis of a minimal bacterial genome
science.org/doi/10.1126/scienc
Discussion: news.ycombinator.com/item?id=3

A goal in biology is to understand the molecular and biological function of every gene in a cell. One way to approach this is to build a minimal genome that includes only the genes essential for life. ...

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2023-07-04

[thread] {digital | cognitive} twins

Interesting intersection of informatics (data storage), nanotechnology (DNA oligomers / molecular genetics), digital realities (digital twins)! ๐Ÿ˜€

Digital twin for DNA data storage based on comprehensive quantification of errors & biases
biorxiv.org/content/10.1101/20

DNA digital data storage
en.wikipedia.org/wiki/DNA_digi

Digital twins
en.wikipedia.org/wiki/Digital_

Victoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธpersagen
2023-06-30

How the motion of DNA controls gene activity
sciencedaily.com/releases/2023

Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion. This allows specific regions to come into contact and thereby activate a gene. A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA.
...

MysteriesOfGeneticsMysteriesOfGenetics@biologists.social
2023-06-27

Lets discover all about #biology #cellbiology #neurobiology #genetics #molecular_genetics and other biology stuff!

#biology #neurobiology #genetics #dna #moleculargenetics #cellbiology #science #proscience #chemics #TheMysteriesOfScience #TheMysteriesOfGenetics #sleepyicedragon #sleepyicedragonRNDM #genes

Bruce Hamiltonbahome
2023-06-20

I love new methods that make everything I learned in grad school obsolete. NEB HiFi cloning 3-fragment assembly scaled down to 6-ul reactions transformed into 1/4 of a โ€œsingleโ€ comp cell aliquot in strip tube. 300 ul SOC, streak 100 ul on a plate, and pick two colonies. Send one for whole-plasmid sequencing (Primodium or Plasmidsaurus) without screening. Perfect.

Petri plate with a biased spread of bacteria to isolate single colonies.

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