😍 SOX2-positive, NESTIN-positive neural progenitor cells differentiated from patient-derived induced pluripotent stem cells. NPCs are generated, banked and quality-tested in our core facilitiy, #Neuracell, for distribution to the neuroscience research community.
Neuracell | https://zurl.co/nmGsh
🔊 Today! Sally Temple is presenting on "Using Patient-derived Induced Pluripotent Stem Cell (iPSC)-derived Organoids to Study the Time-Course of Neurodegenerative Disease" at @Indiana University Bloomington.
🔊 Just out! Drs. David Butler and Eain Murphy teamed up to investigate the impact of HSV-1 infection on Tau protein pathology, a key aspect of Alzheimer's Disease and other neurodegenerative conditions.
#Neuracell
Open Access | https://zurl.co/M50DS
🔊 Next week, Sally Temple will be speaking @Rensselaer Polytechnic Institute on "Neurodegenerative Disease Modeling with Brain Organoids.”
Where | Isermann Auditorium
When | Jan 15, 3pm - 4pm
Today, Sally Temple is speaking at the Center for Genomic Health, @Weill Cornell Medicine in NYC.
Topic: "Using Human Brain organoids to Explore the Progression of Neurodegenerative Disease"
2 month old organoids stained with mTBR1, gpMAP2, and DAPI
Interested in #organoids? Check out #NeuraCell for forebrain, midbrain, or custom organoids from iPSCs! https://zurl.co/1ntB
🔊 New pre-print from David Butler and team!
"HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease"
#organoid #tauopathy #neurodegeneration #scRNAseq #Neuracell
biorxiv | https://zurl.co/iWU1
🔊 This week, Dr. Sally Temple will be speaking at the 2024 Northeast Regional Life Sciences Core Directors symposium. This terrific meeting highlights the value and challenges of implementing shared research resources.
#Neuracell
Learn more at: https://zurl.co/7H4O
Day 20 forebrain organoid section (20um) stained for PAX6 in green, TBR1 in red, BTUB in cyan, and DAPI in blue
Interested in #organoids? Check out #NeuraCell for forebrain, midbrain or custom organoids from iPSCs! https://www.neuracell.org/cell-supply
Taylor Bertucci's recent talk on improved methods for cortical #organoid production and quality analysis was covered by the Pharmacy Times!
#AAIC2024 #NeuraCell #stemcell
Full article | https://zurl.co/5ikN
Read the pre-print! | https://zurl.co/lfZ5
🔊 Check out the latest preprint from David Butler & team: development of an #intrabody collection that targets a-Synuclein, a key protein that accumulates in Parkinson's disease. Efficacy data were generated using #organoids from PD patient stem cell lines in vitro as well as with two in vivo models.
#ParkinsonAwarenessMonth #NeuraCell
This work was supported by the Michael J. Fox Foundation, Parkinson's Foundation, NIH's NIDDK & NIA, & NYSDOH.
Preprint | https://zurl.co/M4aF
Frontotemporal degeneration (FTD) is associated with MAPT mutations, which affect tau protein. We use patient-derived 3D stem cell models to study neural development & degeneration.
Bertucci, et al. | https://zurl.co/JPD6
Cell lines used in this study are part of an outstanding resource collection produced with support from the #RainwaterCharitableFoundation. They are available to the research community through our #Neuracell core facility.
#RareDiseaseDay #tauopathy #endFTD #organoid
We're excited to implement higher throughput #electrophysiology using a @3Brain MicroElectrode Array! Dr. Thomas Kiehl was awarded an NIH instrumentation grant to purchase the system & is working with #NeuraCell to launch this service for the Cap Region #neuroscience community.
Looking forward to the Society for Neuroscience Hudson-Berkshire Chapter Annual Meeting this Saturday University at Albany, SUNY! Dr. Caitlin Hill will join an accomplished panel of speakers, presenting her lab's #SpinalCordInjury research. Many terrific trainees will present posters, as well.
#NeuraCell scientists will be on hand to talk about resources we provide to the neuroscience community, including neural progenitor cells and organoids generated from patient-derived stem cell lines.
Happening now in #NeuraCell: expanding 18 #stemcell lines at once with the help of sustained release growth factors that improve stem cell growth and differentiation! FGF2 DISCs keep our cultures looking beautiful with less effort (and no weekend feeds!)
@StemCultures
🧵2/4 Funded through @NIH, this grant leverages Dr. Kiehl's expertise in #electrophysiology, outstanding support for shared resources through our #NeuraCell core facility, and the robust community of researchers across New York's Capital Region.
Dr. Taylor Bertucci, #NeuraCell scientist and @RPI_BME alum, will be speaking at the Rensselaer Single Cell and Spatial Genomics Symposium, hosted by 10x Genomics, the RPI Genomics Research Core, and Illumina, on March 21st!
Program and registration: https://zurl.co/4AWX
We're making bank(s of human pluripotent #stemcell lines)! #NeuraCell distributes hPSCs & hPSC-derived cell types, including neural progenitor cells & retinal pigment epithelium, made from #tauopathy and #maculardegeneration patient lines.
Request yours: https://www.neuracell.org/cell-supply
This batch: 4 patient hPSC lines, 2 regional identities, 6000+ cerebral #organoids, 1 industrious #stemcell facility.
#NeuraCell
We ❤️ #stemcells for modeling #neurodevelopment, #Alzheimers, #MacularDegeneration and more.
