Lmst

RE: https://mastodon.social/@HafizHusnain/115328490796649616

This review connects molecular biology and clinical neuroscience, showing how #miRNAs could transform how we diagnose and treat neurodegenerative diseases.

Click Here to Access Full Article: https://rdcu.be/eJJJ3

#Neuroscience #Neurodegeneration #Biomarkers #miRNA #MolecularBiology #Alzheimers #Parkinsons #ALS #Huntingtons #biosensors #NGS #Diagnostics #Therapeutics #AcademicMastodon #OpenScience #springernature

🧬 Latest review article published today!
“MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies — advances and challenges.”

Discover how miRNAs, tiny regulators of gene expression, are transforming diagnostics & therapies for Alzheimer’s, Parkinson’s, ALS & Huntington’s disease.

🔗 Read: https://doi.org/10.1007/s10072-025-08419-w

https://doi.org/10.3389/fnmol.2024.1386735

#Neuroscience #miRNA #Neurodegeneration #Biomarkers #MolecularBiology #AD

Postdoc, PhD, Master
Ebner lab

Join the Ebner lab to discover lysosomal lipid logistics pathways

See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/

#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=3455

Day 5: White matter in the brain significantly changes with age. Axons, the connections between neurons, are usually surrounded by an insulating layer called myelin. But not all the myelin is present at birth.

Instead, neurons become myelinated as we get older, with the prefrontal cortex being the last area to myelinate in young adulthood. That’s what people tend to refer to when they say your cortex matures around 25 years old.

Unfortunately, things go downhill from there. Myelin starts to degenerate towards later adulthood. That works on the last-in, first-out principle, with the prefrontal cortex being the first one to go.

#ShyButSharing365 #neuroscience #myelin #neurodegeneration #science

🧠 Forschende vom Max-Planck-Institut zeigen: Kriminelles Verhalten kann ein frühes Warnzeichen für Demenz, besonders frontotemporale, sein. Männer sind besonders betroffen. Ein neues Bewusstsein für Demenz-Symptome ist nötig! #Demenz #Neurodegeneration #Gesundheit https://www.n-tv.de/wissen/Kriminelles-Verhalten-kann-Fruehzeichen-fuer-Demenz-sein-article26004359.html
#newz

Cellular Senescence and Brain Aging: Mechanisms, Therapeutic Strategies, and Implications for Neurodegenerative Diseases by Gaurav Gupta, 2025

In Cellular Senescence and Brain Aging, leading scientists and experts examine
how brain aging relates to senescent cells in the body. This book combines cellular biology and neuroscience, combining molecular, experimental, and translational information.

https://link.springer.com/book/10.1007/978-981-96-8873-9

@bookstodon
#books
#brain
#ageing
#senescence
#neurodegeneration

All these chapters highlight the connection between aging brain cells and the brain’s environment, disclosing the reasons behind neuroinflammation, dysfunction in brain connections, and the death of brain cells.

The book examines the cellular senescence in brain aging processes and its effects on three major neurodegenerative conditions: Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. It discusses basic aging mechanisms, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, before moving on to current treatments such as senolytics and autophagy modulators.
The book is divided into several chapters, with specific sections dedicated to experimental approaches, detection methods, and disease-by-disease analysis of cellular senescence effects. A specific chapter explores the clinical potential of senescence-targeting therapies and discusses upcoming study pathways.
This publication is aimed at researchers in neuroscience, clinicians, graduate students, neuroscientists, and neuropharmacology professionals involved in the assessment of age-related disorders. It delivers thorough expertise by combining research evidence on brain aging with methods to combat cognitive decline. The structured system within this publication creates connections between basic research and medical implementation, providing essential knowledge for treating neurodegeneration.

📣🆕 Just in from #DrugRepurposing on #ScienceOpen:

'International Drug Repurposing Patent Landscaping, Part 3: Chronic Neurodegenerative Diseases 2010–2024'

🔓➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGREPO.25.1.0003

#REPO4EU #PatentLandscape #Neurodegeneration #Alzheimers #Parkinsons

Circadian Harmony: Aligning Sleep-Wake Cycles for Brain Health

#SleepScience #BrainHealth #CircadianRhythm #SleepStages #Memory #Neuroinflammation #Glia #Microglia #Neurodegeneration #Melatonin #Serotonin #SleepBetter

https://youtube.com/shorts/I5G9b4Iemo4?feature=share

Sleep: Your Brain’s Nightly Maintenance Crew

#SleepScience #Neuroplasticity #BrainHealth #Memory #REM #SlowWaveSleep #BDNF #CircadianRhythm #Cognition #EmotionalIntelligence #Neurogenesis #Neurodegeneration #SleepWell #NightShiftBrain

https://youtube.com/shorts/nJHnqpDZlzI?feature=share

#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @PLOSBiology https://plos.io/4fJy7YG