Lmst

#Neutrophils

Zinc plays a central role in the #immunesystem, & #zinc #deficient people experience increased #susceptibility to a variety of #pathogens. It is clear that zinc affects multiple aspects of the #immune system, from the barrier of the #skin to #generegulation within #lymphocytes. Zinc is crucial for normal #development & #function of cells mediating nonspecific #immunity such as #neutrophils and #naturalkillercells.
https://www.angstrom-minerals.com/?dt_id=2139817

Obesity Cripples Anti-Bacterial Immunity: It cripples your white blood cells, the neutrophils, that kill bacteria. #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis
https://www.instagram.com/reel/DH9NiUTtOcR/

#neutrophils, one of the most abundant immune cells, have revealed another superpower: they form natural bandages that cover wounds and keep bacteria out. https://www.nature.com/articles/d41586-025-00796-8

Mind blowing #immunology fact!

We now know that the body's first responders (#Neutrophils) have a multi-pronged attack, and when all else fails they turn into little suicide bombers--spewing out their own #DNA as a microscopic #net to catch and kill #bacteria! 🙀

Somebody was cute and named these "Neutrophil Extracellular Traps" or NETs for short. 🙂

https://en.wikipedia.org/wiki/Neutrophil_extracellular_traps

This photo is from a medical journal and is credited to Dr Volker Brinkmann, Max Planck Institute for Infection Biology, Berlin, Germany. Amazing!! 👍 👏

(Neutrophil extracellular trap (NET) formation. Scanning electron microscopy of neutrophil (yellow) casting a net (green) entrapping Helicobacter pylori bacteria (blue))

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312463

Chronic stress increases #metastasis. Paper describes one mechanism: stress-related glucocorticoids make #neutrophils produce #NETs and thus metastasis-friendly milieu. https://www.cell.com/cancer-cell/fulltext/S1535-6108%2824%2900037-0

"The dysfunction of the cells could be a phenotype predisposing to LCS, but we believe it to be rather a complication of the acute disease. Moreover, this may be a possible explanation for the virus reactivations (EBV, HHV6), the frequent Streptococcal tonsillitis, or upper airway infections of children with LCS observed in our praxis and worldwide with the more serious influenza or RSV seasons."

https://www.nature.com/articles/s41390-024-03731-1

#CovidIsNotOver #COVID #COVID19 #SARSCoV2 #neutrophils #LongCovidKids #LongCOVID

Maybe one of the most interesting things to me, as a lay person, in https://www.nature.com/articles/s41390-024-03731-1 is (as I read this) a lab Dx for Long Covid in children can be done right now, and distinguishes cleanly from convalescent children without Long Covid symptoms (Figure 4: D, K, and I).

I read this Nature paper as absolutely putting to rest claims that children aren't getting LC or that it's post-2020 trauma and so on. There's been other evidence before but I don't remember other gaps that were so clean.

h/t a half dozen zeroes.ca and other fedisci folks

#CovidIsNotOver #COVID #COVID19 #SARSCoV2 #neutrophils #LongCovidKids #LongCOVID

Pre-metastatic neutrophilia and lung-metastatic breast cancer: a one-two punch to the lungs 🫁

Simon Cleary highlights recent work from the group of Leo M. Carlin. #preprint

“The methods developed for use in this study are impressive…”

Check out the preLight 👉 https://prelights.biologists.com/highlights/neutrophil-slowing-obstructs-the-capillaries-of-the-pre-metastatic-lung-in-breast-cancer/

#breast #biology #cancer #metastasis #neutrophils #immunology

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

β-Glucan Reprograms #Neutrophils to Induce Disease #Tolerance Against #Influenza A Virus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.02.610822v1

Collectively, our data indicate that β-glucan reprograms hematopoietic #stem cells (HSCs) to generate neutrophils with a novel 'regulatory' function, which is required for promoting disease tolerance and maintaining #lung tissue integrity against viral infection.

How water influx and swelling in #neutrophils help them migrate. https://elifesciences.org/reviewed-preprints/90551?utm_source=mastodon&utm_medium=social&utm_campaign=organic

The [#Candida_albicans] #fungi in our guts can make cases of Covid worse: The immune system [courtesy of #neutrophils] can get kicked into overdrive when the fungi run riot, 20240421,
by Maggie C,
https://arstechnica.com/health/2024/04/the-fungi-in-our-guts-can-make-cases-of-covid-worse/
#moreResearchIsNeeded

... can't help but do ...

Zoot Suit Riot
by Cherry Poppin' Daddies
https://vid.puffyan.us/watch?v=bfxpkfQRqGo
https://www.youtube.com/watch?v=bfxpkfQRqGo

#CoViD2019 #biology #humanBody #microbiome #humanGut

Mechanisms of metastasis.

'Together, our data show that glucocorticoids released during chronic stress cause NET formation and establish a metastasis-promoting microenvironment. Therefore, NETs could be targets for preventing metastatic recurrence in cancer patients, many of whom will experience chronic stress due to their disease.'
#Cancer #Neutrophils #Metastasis #Immunology

https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00037-0?