Low #OscillatoryShearStress->
⏫Osteopontin-CD44 in #EndothelialCell->
⏫EndMT->
⏫24% of neointimal cells at rat aortocaval junction
A cascade independent of #HyaluronicAcid🤓
Dr. Yung-Hsin Yeh lab Kidney Int 2023
https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext
#EndothelialCell Mst1 KO->
⏫EC inflammation by #OscillatoryShearStress 0.5±4 dyn/cm2 1 Hz
⏫🐭#Atherosclerosis
Independent of #YAP (?TAZ🧐)
Mst1 phosphorylates #Connexin43->⏬Hemichannel activity, not gap junction coupling
Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322
