#Plasmamembrane

2024-04-25

Exploring the Intricacies: The Structure of the Plasma Membrane

, , , , , , , , The plasma membrane, also known as the cell membrane, is a vital component of all living cells. It serves as a protective barrier, separating the interior of the cell from its external environment. Beyond its role in maintaining…

micrordt.wordpress.com/2024/04

2024-04-25

Unveiling the Architect of Life: Exploring the Plasma Membrane

, , , , , , , , , , , Composed primarily of lipids, proteins, and carbohydrates, the plasma membrane exhibits a dynamic and heterogeneous structure. Phospholipids, with their hydrophilic heads and hydrophobic tails, form the…

micrordt.wordpress.com/2024/04

2023-08-22

Up for a road trip?🚗
Sphingolipids act as signaling molecules in many cellular processes. Join us on this adventure to learn more about the #sphingolipid #biosynthetic pathway!🛣️
doi.org/10.1111/jipb.13461
@wileyplantsci
#PlantScience #JIPB #Arabidopsis #signaling #PlasmaMembrane

Diagram of the ER membrane to illustrate that activated MPK3 and MPK6 phosphorylates AtLCB1, which in turn strengthens its binding with AtLCB2b, promotes its binding with ssSPTs, and stimulates the formation of higher order oligomeric and active SPT complexes.
2023-03-03

Li et al. report that #phosphorylation of the serine palmitoyltransferase LCB1 subunit stimulates its activity and modulates #sphingolipid #biosynthesis in #Arabidopsis.
doi.org/10.1111/jipb.13461
@wileyplantsci
#PlantScience #JIPB #signaling #PlasmaMembrane

Diagram to illustrate the process by which activation of MPK3 and MPK6 by the upstream MKK9 and treatment with Flg22 increases SPT activity and induces the accumulation of sphingosine long-chain base t18:0. Activated MPK3 and MPK6 phosphorylate AtLCB1.
2023-02-15

EMBO Journal Issue 4/23:
- Commentary on #creativity needs in research
- #Degron recognition in orphan complex subunits by CLR4-DCAF12 E3 #ubiquitin #ligase
- #Plasmamembrane topography of #IgM #Bcell receptors
- #YAP roles and regulation in #tumorigenesis
- #Brassinosteroid interplay with #katanin #microtubule severing

Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
embopress.org/toc/14602075/202

EMBO Journal 4/23 cover features a cartoon depiction of yeast Derlin Dfm1 as a parcel service van, delivering an "Orm2"-labelled package to a household postal box that form part of a Golgi vesicle stack.
Gonzalogcordova
2023-02-07

Just Published!

"Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease"

link.springer.com/chapter/10.1

2023-01-11

#Plasmamembrane topography governs the 3D dynamic localization of #IgM #Bcell #antigenreceptor clusters

Deniz Saltukoglu, Michael Reth et al at University Freiburg use high-resolution #microscopy on the #Burkitt’s Lymphoma model Ramos B-cell line to reveal surface topographical features facilitating screening of #antigens

embopress.org/doi/10.15252/emb

Schematic visualization of the article's synopsis
2023-01-09

After a short Christmas break, my weekly #Science report is back!

If you are interested in #InterorganellarConnectivity, make sure to check out the latest selection of publications on #MembraneContactSites !

biomed.news/bims-mecosi/2023-0

Pre-selected by #BioMedNews, an abstract-selecting service based on #MachineLearning and #ArtificialIntelligence, combined with manual validation by me.

Happy reading!

#ER #Mitochondria #MAMs #PlasmaMembrane #Apoptosis #CardiovascularDisease #Lipids

A selection of micrographs depicting membrane contact sites in yeast
2022-12-13

What controls dynamic #Epithelial-to-#Mesenchymal Transition of #cancer cells?

Peter ten Dijke Lab at LUMC Leiden identify #plasmamembrane #glycosphingolipid composition and expression of their biosynthesis enzymes as key determinants of dynamic #EMT and #malignant transformation in human #epithelia

embopress.org/doi/10.15252/emb

Schematic image visualizing the findings of the article
ST3GAL5-catalyzed gangliosides inhibit TGF-β-induced epithelial-mesenchymal transition via TβRI degradation

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