🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

Excited that Christina Woo (Harvard University) will visit us for a @LED3hub Lecture.

Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #Chemistry and #ProteinDegradation.

https://www.nature.com/articles/s41586-022-05333-5

Excited that Christina Woo (@thewoolab.bsky.social, @harvard.edu) will visit us for a @led3hub.bsky.social Lecture. Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #ChemSky and #ProteinDegradation. www.nature.com/articles/s41...

RE: https://bsky.app/profile/did:plc:jnlt3o3km3ebst2vcigkwdch/post/3lvbicnjmyv2o

Tagging of proteins for their inducible degradation is a great tool for the study of gene function. A systematic investigation of what sequence triggers protein degradation in #yeast is timely:

https://pubmed.ncbi.nlm.nih.gov/38102142/

#ubiquitin #proteindegradation #molecularbiology #genetics

ASGPR-mediate clearance of PCSK9 via LYTACs - various flavors showing modular flexibility to yield degraders #proteindegradation #PFEColleague https://bit.ly/3ZoiBIR

Dihydrouracil CRBN PROTAC ligands; better aqueous/base stability than IMiDs and eliminates a chiral center that easily racemizes. In NVS PROTAC patents since 2019 but nice to see in the published literature #proteindegradation #PFEColleague https://bit.ly/3ZeG7Iw

To degrade or not to degrade? That is the question answered by @haselbachlab in 2023's first video. Enjoy a mini lecture on #proteindegradation, #cryoEM, & #structuralbiology: 📺https://youtu.be/bU0UOJJBqH4

Hello! I am an MRC CDA fellow in the Pharmacology department at the University of Cambridge. Me and my research group are fascinated by the molecular mechanisms that underlie protein self-assembly. We work on strategies to prevent amyloid formation and we are using engineered biomolecular condensates to gain insights into how Nature utilises phase separation to facilitate protein degradation. #neurodegeneration #BiomolecularCondensates #proteindegradation #introduction #Proteindesign

New spin in heterobifunctional lysosomal degraders using integrin receptors for target internalization/lysosomal degradation #proteindegradation #PFEColleague https://bit.ly/3Xzj8XA

Referenced link: https://phys.org/news/2022-10-elegans-temperature-perception-protein-degradation.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-10-elegans-temperature-perception-protein-degradation.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1578390649845465088#m

C. elegans study: Temperature perception influences #proteindegradation and lifespan @UniCologne @NatureComms https://www.nature.com/articles/s41467-022-33467-7 https://phys.org/news/2022-10-elegans-temperature-perception-protein-degradation.html