A new analysis of gene expression in blood samples identifies molecular signatures of DNA repair and cellular stress that may be detectable years before Parkinson’s motor symptoms appear. The study traces prodromal individuals and finds these blood-based signals rise early and fade as the disease becomes established.

For psychology-oriented readers, the work highlights how early biological processes precede visible symptoms, offering insight into risk markers and the potential for early intervention in neurodegenerative conditions.

Article Title: Blood test might detect Parkinson’s disease years before physical symptoms appear

Link to PsyPost Article: ift dot tt/WdhuRjg

Copy and paste broken link above into your browser and replace "dot" with "." for link to work. We have to do it this way to avoid displaying copyrighted images.

#ParkinsonsDisease
#Biomarkers
#ProdromalPhase
#RNASequencing
#EarlyDetection

Four years after publishing my work on machine-driven parameter screen of biochemical reactions, it still has zero citations. That makes me sad; I am really proud of this work. So I asked ChatGPT to suggest me hashtags, for another chance to reach readers. https://academic.oup.com/nar/article/48/7/e37/5728495 #MolecularBiology #BiochemicalReactions #ReverseTranscription #RNASequencing #LabAutomation #GeneExpression #SingleCellAnalysis #HighThroughput #AIinScience #ComputationalBiology #BiotechInnovation #DataDrivenResearch

Do you know gget by the Pachter lab? You should! It now includes efficient querying of Bgee in Python. Get high quality curated gene expression data directly in Python or command line. https://pachterlab.github.io/gget/en/bgee.html #RNAseq #biocuration #Python #scRNAseq @SIB @marcrr @fbastian @dee_unil

#bgee #Bioinformatics #RNASequencing #SingleCellRNASeq #Genomics #Transcriptomics #GeneExpression #ComputationalBiology #SingleCellAnalysis #GeneExpressionAnalysis

scAN1.0: Flujos de trabajo #bioinformáticos reproducibles, modulares e interoperables para analizar #singlecell #RNAsequencing data. - #ENSdeLyon https://doi.org/10.3233/ISB-220252

Today's topic is "Next-Generation Sequencing" 🧬 🤩 🧬

Our graduate students(MCBG/Biochemistry/Cancer Bio/Biotech) leaning and discussing sequencing analyses led by Dr. Joshua Mell, Drexel University College of Medicine 🤔

#BiomedicalScience #GraduateSchool #GraduateStudies #NextGenSequencing
#DNASequencing
#RNASequencing

"We present TEQUILA-seq, a versatile, easy-to-implement, and low-cost method for targeted long-read #RNA-seq utilizing isothermally linear-amplified capture probes. When performed on the Oxford #nanopore platform with multiple gene panels of varying sizes, TEQUILA-seq consistently and substantially enriches transcript coverage while preserving transcript #quantification."

https://www.nature.com/articles/s41467-023-40083-6

#sequencing #RNAsequencing

The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males. https://doi.org/10.1186/s12864-023-09462-7 #LewisLungCarcinoma #BiologicalSexDimorphism #RnaSequencing #TypeIiInterferon #CancerCachexia

And now I have to deal with 600 internal legacy Illumina short RNA sequencing datasets.
I don't even remember where to start and have to whip the posters in 2 days 🤣
Let's just say that this is nearly as bad as an organic kale salad.
Which aligner I am supposed to use now? (I used to remember this stuff)
#RNAsequencing

Using #Perl to slave drive the Xeon to map some RNA libraries #RNAsequencing #NanoporeSequencing

🩸 🧬 🖥️ 👨‍⚕️ ⚕️
@CRCHUM & @TheRealSmithLab at @CR_CHUSJ are working towards bringing molecular #PrecisionMedicine to #IntensiveCare decision support systems by leveraging #MachineLearning models and ultra-fast #RNAsequencing for improved patient care

Merci @GenomeQuebec & @IVADO_Qc

https://www.genomequebec.com/2533-en/news-genomics-in-the-digital-age-ivado-and-genome-quebec-foster-interdisciplinary-research/

All right,
I am Christos Argyropoulos, Division Chief, Nephrology, University of New Mexico
Posts from this account limitee to:
Data Science, Bioinformatics, Computing, Statistics
Some searchable hastags

#RNAsequencing #Nanopore
#GLMMs #Rstats #Bayesian
#Perl #HPC #Statistics #transcriptomics #epigenetics #BigData

#intro post for #ScienceMastodon - I’m a #compsci turned #compbio turned product manager at PacBio. I still code tho 🤣 over the years I’ve been supporting, developing, and collaborating use of long read for #RNAsequencing with recent foray into #singlecell where I helped put out the MAS-Seq single cell kit. My other day job is long reads for AAV #genetherapy, a new field I literally knew zero about until less than a year ago 😉 it’s part of the fun of being at a sequencing company!

Alright #singlecell #RNAsequencing folks if you wanna hear about the PacBio MAS-Seq to isoforms for ya fav cell types, the webinar is 11/16 — we’ll walk you through the workflow and bfx https://programs.pacificbiosciences.com/l/1652/2022-10-11/43qvqn

Put these flow cells in my sequencer.
#rnasequencing
@nanopore@twitter.com @oxfordnanopore@twitter.com

Hash tags if you are looking someone to follow. I have diverse interests and while I identify as a #Nephrologist = #kidneydoc,
I will tweet about #statistics, #highperformancecomputing #bioinformatics , #RNAsequencing , #immunology and random funny (at least to me) stuff.
I absolutely think the civilization should eliminate kale - I am a #zerokale account , because of the harm and injury caused by kale salads worldwhile.

Just uploaded our poster for @NanoporeConf@twitter.com .
Simultaneous short and long RNA sequencing from the same run: microRNA, tRNA, lncRNA, coding RNAs etc.
@MorganMacKenz12@twitter.com did most of the hard work of course
#RNAsequencing #transcriptomics #bioinformatics
#NGS

#introduction time. So I look after the lab operations at Edinburgh Genomics- we have #AllTheToys. #PacBio #illumina #nanopore and all the #skills. Interested in magical things like native #RNAsequencing #SingleCellSequencing RNA/DNA modifications. Also #guitars #Scotland #wildlife. (Is this a dating profile?)

The Mechanisms of Virus-Host-Interaction during Infections

https://tilvids.com/w/qZuJkW4K9eVqUuRNpBXg3r