Molecular basis of #SARS-CoV-2 proofreading enzyme–mediated #resistance to #remdesivir, https://etidiohnew.blogspot.com/2025/10/molecular-basis-of-sars-cov-2.html
#Remdesivir
#Remdesivir: Effectiveness and Safety in Hospitalized #COVID19 #Patients—Analysis of Retrospectively Collected Data from Daily Practice in #Omicron Variant Era and Comparison with the Pre-Omicron Period, https://etidiohnew.blogspot.com/2025/09/remdesivir-effectiveness-and-safety-in.html
#SARS-CoV-2 #Remdesivir Exposure Leads to Different Evolutionary Pathways That Converge in Moderate Levels of Drug #Resistance, https://etidiohnew.blogspot.com/2025/07/sars-cov-2-remdesivir-exposure-leads-to.html
#Remdesivir, mAb114, REGN-EB3, and #ZMapp partially rescue nonhuman #primates infected with a low passage #Kikwit variant of #Ebola virus, https://etidiohnew.blogspot.com/2025/04/remdesivir-mab114-regn-eb3-and-zmapp.html
#Remdesivir and #Obeldesivir Retain Potent #Antiviral Activity Against #SARS-CoV-2 #Omicron Variants, https://etidiohnew.blogspot.com/2025/01/remdesivir-and-obeldesivir-retain.html
esperances) i alguns altres tractaments potencialment prometedors (per ex., #remdesivir). S'ha de dir, no és ironia, que de vegades hi ha molècules terapèutiques que estan a la recerca del virus q les faci més útils.
Tots els brots de #Marburg han estat petits (un parell de centenars de casos) o molt petits (per sota de 10, o 2, o 1). Per tant MAI s'ha pogut provar cap desenvolupament vaccinal "en el camp" perquè quan s'hi arriba, el brot llangueix. Però no deixa de ser lamentable. Això...
Triple #combination of #Remdesivir, #Molnupiravir & #Ribavirin is highly efficient in inhibiting #coronavirus #replication in #human nasal #airway epithelial cell cultures & in a #hamster infection model. Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002031?via%3Dihub
Combining Remdesivir, molnupiravir, & ribavirin increases the antiviral efficacy against coronavirus OC43. This triple therapy also eliminates #SARS-CoV-2 replication in #lungs of infected hamsters, unlike double combinations.
Habe nun gelernt, dass Katzen an einem mutierten felinen Corona Erreger erkranken, der gar nicht mal so unüblich ist, zu Multiorganversagen führt und es nur ein (nicht zugelassenes) Medikament gibt, was 90%+ Suppression bis Heilungschancen bringt.
Nummern zu Dealern werden in Internetforen, WhatsApp Gruppen, Instagram und bei einigen Tierarztpraxen weitergegeben.
Does anyone on #fedi have any reliable information about the disease FIP in cats?
One of my kittens was preliminarily diagnosed today and I'm trying to find help.
Also, does anyone in the #Portland OR area have access to any #GS441524 or #Remdesivir?
Please let me know!
#cats #cat #catsofmastodon #fip #portland #oregon #seattle #washington #eugene #fediverse #gs-441524
Comparative #effectiveness of #combination #therapy with #nirmatrelvir–ritonavir & #remdesivir versus #monotherapy with remdesivir or nirmatrelvir–ritonavir in patients hospitalised with #COVID19: a target #trial emulation study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00353-0/fulltext?rss=yes
Our study highlighted the potential for reduced #risk of #mortality, #ICU admission, or need for ventilatory support in patients hospitalised with COVID-19 treated with nirmatrelvir–ritonavir as a monotherapy ...
Whenever Dr. Fauci was actually allowed to respond to questions from Republican lawmakers,
he took the opportunity to push back on many of the conspiracies about his role in the pandemic.
Rep. Nicole #Malliotakis (R-N.Y.) attempted to press Dr. Fauci over claims that Covid-19 originated from a research laboratory, or the so-called “lab leak” theory.
“I don’t think the concept of there being a lab leak is inherently a conspiracy theory,” Fauci responded.
“What is conspiracy is the kind of distortions of that particular subject, like it was a lab leak and
I was parachuted into the CIA like #Jason #Bourne
and told the CIA they shouldn’t be talking about a lab leak.”
When asked if he received any royalties from Big Pharma since 2021, Fauci responded that he’s made “zero” dollars in pandemic royalties.
#NIAID #Ross #Dingell #Anthony #Fauci #David #Morens #FOIA #lady #Wenstrup #Tokuda #Daszak #remdesivir
As head of #NIAID and a presidential adviser, Fauci helped guide the public during the pandemic on measures to avoid infection,
such as mask-wearing and maintaining physical distance.
But at a May 22 hearing, Wenstrup said Fauci’s NIAID “was, unfortunately, less pristine than so many, including the media, would have had us all believe.”
In his letter to Bertagnolli, Wenstrup said there was evidence that a former chief of staff of Fauci’s might have used intentional misspellings
— such as a variant of “EcoHealth”
— to prevent emails from being captured in keyword searches by FOIA officials.
WHY WERE MORENS’ EMAILS ALARMING?
The emails show a pattern of trying to shield communications from public disclosure.
“We are all smart enough to know to never have smoking guns,
and if we did we wouldn’t put them in emails,
and if we found them we’d delete them,” Morens wrote on June 16, 2020.
“The best way to avoid FOIA hassles is to delete all emails when you learn a subject is getting sensitive,” he wrote on June 28, 2021.
Some of Morens’ emails included sexual or sexist remarks, including one from December 2020:
“Beverage is always good, and best delivered by a blonde nymphomaniac.”
In another email, discussing how former Centers for Disease Control and Prevention Director Rochelle Walensky got her job, he remarked,
“Well, she does wear a skirt.”
Morens apologized at the May 22 hearing and called some of what he wrote “misogynistic.”
“Some of the emails I’ve seen that you all have provided look pretty incriminating,” he testified.
Asked if he ever sent information related to covid to Fauci’s personal email, he said he didn’t remember but might have.
Morens said some of his comments were “snarky jokes” intended to cheer up his friend Daszak, the EcoHealth president, who was receiving death threats over media coverage of his organization’s relationship with the Wuhan lab.
Morens testified that he didn’t knowingly delete official records.
#Ross, the North Carolina representative, said the emails
“inflict serious damage on public trust for the entire scientific enterprise.”
She said the dangers can be seen in eroding public confidence in vaccines, contributing to recent outbreaks of measles.
Rep. Debbie #Dingell (D-Mich.) said Morens showed disdain for the Freedom of Information Act.
The subcommittee’s investigation has been an unfounded effort to pin the blame for the pandemic on NIH and NIAID, and Morens’ emails have helped blur the issues, she said.
DO THE EMAILS REVEAL THE ORIGINS OF COVID?
No, as Democrats have emphasized.
In a way, Morens’ correspondence undercuts allegations that people at the top of NIAID covered up a lab leak in Wuhan.
None of Morens’ emails describe any effort to suppress evidence of a lab leak and, in an email sent from a private account,
he ridiculed the idea, calling it “false to the point of being crazy.”
But the subcommittee’s senior Democrat, Ruiz, criticized Morens for dismissing the lab leak theory.
“Unless and until we see specific evidence on the origins” of the virus that causes covid, “the scientific process requires that we examine all possible hypotheses with objectivity,” Ruiz said.
#Anthony #Fauci #David #Morens #FOIA #lady #Wenstrup #Tokuda #Daszak #remdesivir
Former National Institutes of Health official #Anthony #Fauci has faced many hostile questions from members of Congress,
but while appearing before a House panel on Monday, he’ll have something new to answer for:
a trove of incendiary emails written by one of his closest advisers.
In the emails, #David #Morens, a career federal scientist now on administrative leave,
described deleting messages and using a personal email account to evade disclosure of correspondence under the Freedom of Information Act.
“i learned from our #FOIA #lady here how to make emails disappear after i am foia’d but before the search starts,
so i think we are all safe,” Morens wrote in a Feb. 24, 2021, email.
“Plus i deleted most of those earlier emails after sending them to gmail.”
The pressure is on, as Fauci himself prepares to appear today (June 3) before a House subcommittee exploring the origins of covid-19.
The NIH, a $49 billion agency that is the foremost source of funding in the world for biomedical research,
finds itself under unusual bipartisan scrutiny.
The subcommittee has demanded more outside oversight of NIH and its 50,000 grants and raised the idea of term limits for officials like Fauci,
who led the National Institute of Allergy and Infectious Diseases, an NIH component, from 1984 to 2022.
Lawmakers are likely to put Fauci on the spot about Morens’ emails at a time when Republicans are questioning NIH’s credibility and integrity.
Even Democrats have cautioned the agency’s leaders.
“When people don’t trust scientists, they don’t trust the science,” Rep. Deborah Ross (D-N.C.) told Morens.
⭐️The subcommittee has yet to turn up evidence implicating the NIH or U.S. scientists in the pandemic’s beginnings in Wuhan, China.
⭐️Nor has its work shed light on the origin of the virus.
⭐️But in a May 28 letter to NIH Director Monica Bertagnolli, the subcommittee’s chairman, Rep. Brad #Wenstrup (R-Ohio), said
the evidence “suggests a conspiracy at the highest levels of NIH and NIAID to avoid public transparency regarding the COVID-19 pandemic.”
Rep. Jill #Tokuda, a subcommittee Democrat from Hawaii, said the evidence shows no such conspiracy.
She predicted the bipartisan criticism of Morens, 76, will give way to “a clash of intentions” at the hearing as Republicans try to pin covid on Fauci.
“For them, I think this is their moment to, again, bring a lot of these baseless, false allegations to the front,” Tokuda said.
On May 29, Wenstrup asked Fauci to turn over personal e-mails ahead of his testimony.
Here are things to know as the subcommittee gears up for Fauci’s appearance.
WHAT IS THE SUBCOMMITTEE LOOKING FOR?
The Select Subcommittee on the Coronavirus Pandemic is supposed to be investigating
🔸how the pandemic started
🔸and the federal government’s response.
That includes such hot-button issues as 🔹vaccination policies and 🔹school closures.
🔥A central question is whether the covid virus leaped from animals to humans at a market in Wuhan, China, or spread from a leak at the nearby Wuhan Institute of Virology.
💥The Wuhan lab received funding from an NIH grant recipient called EcoHealth Alliance.
The congressional probe is in some ways an extension of the nation’s political, cultural, and scientific battles arising from the pandemic.
👉The Republican-led subcommittee has been examining NIH’s performance and that of Fauci, who advised both former President Donald Trump and President Joe Biden, becoming the face of many of the government’s most polarizing pandemic policies.
👉The panel called for the government to cut off EcoHealth’s funding, a process the Department of Health and Human Services recently initiated.
👉EcoHealth’s president, Peter #Daszak, was Morens’ friend and the recipient of many of the emails under scrutiny.
A wildlife biologist credited with helping to develop the first covid antiviral drug, #remdesivir, Daszak said he and his organization did nothing wrong.
“We were so accurate in our predictions that a bat coronavirus would emerge from China and cause a pandemic, that when it did, we’re dragged in front of the crowd with their pitchforks and blamed for it,” Daszak said in an interview.
WHAT’S AT STAKE FOR NIH?
The Republican-led subcommittee is challenging NIH’s credibility.
The agency performs and funds a wide variety of medical and scientific research, work that is often the foundation of new medicines and other treatments, and has long enjoyed bipartisan support from Congress.
The agency is home to the “Cancer Moonshot,” a Biden priority.
https://www.scientificamerican.com/article/fauci-faces-congressional-committee-over-covid-e-mails/
The triple #combination of #Remdesivir (GS-441524), #Molnupiravir and #Ribavirin is highly efficient in inhibiting #coronavirus #replication in human nasal #airway epithelial #cell cultures and in a hamster infection model http://biorxiv.org/cgi/content/short/2024.05.14.594200v1?rss=1
Our finding indicate that co-administration of approved drugs for treatment of CoVs infections should be further explored but also vs other families of viruses w/ epidemic and pandemic potential for which no effective antiviral treatment is available.
Ciencia en Españistán a pesar de todos los palos que nos ponen en las ruedas:
En el @CSIC hallan que la combinación de #ribavirina y #remdesivir elimina con rapidez el #SARS-CoV-2 al inducirle un exceso de mutaciones que le impiden multiplicarse. https://www.csic.es/es/actualidad-del-csic/un-estudio-liderado-por-el-csic-halla-una-combinacion-de-farmacos-eficaz-frente-al-sars-cov-2
Wir leben in #Märchen-haften Zeiten!
Leute glauben an #Echsenmenschen, an Zaubertränke wie #Andrenochrom oder #Remdesivir. Wir sehen Hexer wie #Bhakdi oder #Trump. Und #Sagen vom kleinen germanischen und riesigen #Volk von #Russland mit einem #Zar und neuem Traum vom alten #Führer ...!
Klingelts noch bei Tamiflu? Remdesivir?
Werden wir bei der nächsten Pandemie klüger entscheiden oder wieder panisch Milliarden für sinnlose Medikamente verschwenden?
Nun, dafür müßten die Verantwortlichen zunächst aus den schwerwiegenden Fehlern, die gemacht wurden Lehren ziehen ...
... im folgenden Artikel kann man exemplarisch nochmals das simple aber effektive Drehbuch von Pharmafirmen wie Gilead Revue passieren lassen, mit dem die EU über den Tisch gezogen wurde:
Karnataka govt underreported 1.2 lakh COVID deaths, says PAC report
The committee found that large quantities of tablet ivermectin were purchased even though WHO discredited it and ventilators given through PM Cares Fund were given to private hospitals.
#karnataka #covid #CovidDeathToll #BJP #KarnatakaGovt #PMCaresFund #PAC #ivermectin #WHO #amphotericin #remdesivir #healthcare #medicine #covid19 #india
[Articles] Intravenous #aviptadil and #remdesivir for #treatment of #COVID19-associated hypoxaemic respiratory failure in the #USA (TESICO): a randomised, placebo-controlled trial https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00147-9/fulltext?rss=yes #antivirals #medicine
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