#Shigella

Protect Our Province AlbertaPopAlberta@mstdn.ca
2025-06-22

We’re hearing there is a #Shigella outbreak in the Beltline #yyc.

Why hasn’t there been any public messaging about this?

#ableg #abhealth

2025-05-02

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @enningal &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @PLOSBiology plos.io/4jXrr9Z

Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.
2024-12-10

Raw cucumber and carrot salad with raw milk in your salad dressing seems like quite the appropriate thing to put on a menu for the celebration of incoming CDC/FDA officials. #salmonella #shigella #birdflu #salad

2024-05-13

Understanding Shigella: Causes, Symptoms, and Prevention

, , , Introduction: Shigella is a group of bacteria that can cause a highly contagious infection known as shigellosis. This bacterial infection…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

micrordt.wordpress.com/2024/05

:🍪:Semelesemele
2024-03-16

outbreak in Australia.
"Anyone with symptoms has been encouraged to stay hydrated and practise good hand hygiene.", says Doc.
That'll keep the lid on it.👍 .

2024-02-06

Meet Dr Vincenzo Torraca
@VinTorraca , 1st author of new paper from
Serge Mostowy's lab at #LSHTM that analysed the transcriptome of #zebrafish larvae infected with #Shigella flexneri to discover host susceptibility factors

Interview & RA:
👨🏻‍🔬journals.biologists.com/dmm/ar
📰journals.biologists.com/dmm/ar
#OpenAccess

Photograph of Vincenzo Torraca
2024-01-17

#Shigella -Infektionen sind weltweit die zweithäufigste Ursache tödlicher Durchfallerkrankungen. Martin Thanbichler &Team @mpi_marburg fanden einen Schalter, der die Infektion steuert - ein potenzieller neuer Forschungsansatz für zukünftige Therapeutika.
nachrichten.idw-online.de/2024

Foto darf nur im Zusammenhang mit der Pressemitteilung verwendet werden.
2023-12-28

I see in the news an article about a #Shigella breakout. Being curious and having never heard of Shigella, I searched #Bing. Before clicking on any links, I see in the corner this excerpt from #Wikipedia noting, "...is genetically closely related to #Escherichia and #Antisemitism." Wait, what? Antisemitism is now a bacterial infection? I think not. The Wikipedia article does NOT say this, so the Bing result is #weird.

Wiki: en.wikipedia.org/wiki/Shigella

Search results: bing.com/search?q=shigella&for

Screenshot of Bing search results for Shigella showing beginning of Wikipedia description: "Shigella is a genus of bacteria that is Gram-negative, facultatively anaerobic, non-spore-forming, nonmotile, rod-shaped, and is genetically closely related to Escherichia and Antisemitism. The genus..."
Giuseppe MichieliGMIK69@mstdn.science
2023-09-21

''Since the first case was reported on 28 June 2023, and as of 29 August 2023, a total of 2,389 suspected cases have been reported, including 52 deaths (overall Case Fatality Rate (#CFR) 2.2%). Laboratory analyses performed by the National Public Health Laboratory, identified 83 cases of #Shigella, 22 of #Salmonella Typhi (S. Typhi) and 21 cases of #Vibrio cholerae with toxigenicity testing of the strain not performed.''

2023-09-08

Nice papers that #neutrophils can also be epigenetically reprogrammed by infection - stemming from effects on stem cells.

Both use #zebrafish as model

#Shigella: science.org/doi/full/10.1126/s

#Salmonella: science.org/doi/10.1126/sciadv
#trainedimmunity #immunology #epigenetics

2023-03-16

The spread of #Shigella depends more on climate factors than assumed. These findings publ.@LancetGH involving authors from the Infectious Disease Epidemiology Dpt @BNITM_de can help prioritise risk populations in Sub-Saharan #Africa 4 control measures e.g. bit.ly/3J07dwZ
---
RT @LancetGH
From the March issue: Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using indivi…
twitter.com/LancetGH/status/16

Figure 4: The picture shows three world maps arranged on top of each other with grey, purple, beige and brown colours, visualising the geographical distribution of the annual mean prevalence of Shigella infection in children aged 12–23 months predicted by the final model by symptom status. ©The Lancet Global Health
2023-03-04
2023-03-01

CDC warns of increase in extensively drug-resistant shigellosis, a serious gut bacteria. Additionally, shigella can spread this resistance to other gut bacteria.

Many of the recent shigella outbreaks have occurred among the unhoused population and among Men who have Sex with Men (MSM).

emergency.cdc.gov/han/2023/pdf

#shigella #cdc #AntibioticResistance #msm #Sti

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