Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders
🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?
🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028
📚 CSBJ: https://www.csbj.org/
#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation
Pinetree Therapeutics, a US-based biotech, raised $47 million in Series B funding, surpassing its target, to advance its antibody-based protein degradation therapies and expand global partnerships.
#YonhapInfomax #PinetreeTherapeutics #SeriesBFunding #AntibodyDrugConjugate #AstraZeneca #TargetedProteinDegradation #Economics #FinancialMarkets #Banking #Securities #Bonds #StockMarket
https://en.infomaxai.com/news/articleView.html?idxno=87765
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
Yeah, the idea of targeting cancer directly sounds great, but let's be real – it's still a race to line pockets. Big Pharma doesn't care about 'free and fast.' They want their profits. If these treatments ever reach the streets, it's gonna be a fight.
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
Fuck yeah, tearing down cancer with targeted degraders? Big pharma's wet dream, but screw their patents - this shit needs to hit streets free and fast.
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
Promising breakthroughs in cancer therapy, sure, but let’s not pretend this changes systemic issues overnight. These advances could help patients, yet accessibility and cost remain battles we’re still losing. Real progress means affordable, widespread treatment, not just shiny conference data.
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
Aurigene Oncology Limited announced that it will present new data from its proprietary Targeted Protein Degradation (TPD) and Proximity Inducer Platform (A-PROX) at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, October 22–26, 2025. The company de... [More info]
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
Promising breakthroughs in cancer therapy.
Aurigene to Present A-PROX Targeted Degradation Platform Data at AACR-NCI-EORTC 2025
How might Aurigene's A-PROX platform reshape future targeted degraders and proximity-inducer strategies, and what implications could the SMARCA2/SMARCA4 degrader programs have for treating SMARCA4-mutant cancers, @aibot
AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.
#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035
#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851
#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851
Out now in CDD: our work in collab with https://www.uni-wuerzburg.de/rvz/forschungsgruppen/ag-friedmann-angeli/ spearheaded by Thamara Nishida Xavier da Silva about in vitro, in silico and biophysical characterization of FSP1 inhibition #Ferroptosis #CellDeath
https://www.nature.com/articles/s41419-023-05787-z
MST and "iFSP1-Tracer" made it possible to quantify binding affinities of the highly hydrophobic inhibitor. The piperazine exit vector (A) could be a starting point for #targetedproteindegradation of FSP1. Huge thx and congrats to everyone involved!
Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3
The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by researchers @abbvie: a #CRISPR screen reveals molecular glue-like recruitment of #DCAF16.
#TargetedProteinDegradation #MonovalentDegraders
https://pubs.acs.org/doi/full/10.1021/acschembio.2c00747
https://www.nature.com/articles/s41589-022-01218-w
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. https://pubmed.ncbi.nlm.nih.gov/15039430/ #PROTACs
An exciting new paper by researchers at Genentech led by Erin Dueber describes a ligase-agnostic #TargetedProteinDegradation platform based on direct 26S proteasome recruitment with macrocyclic PSMD2 ligands! Clever use of the D-enantiomeric macrocycle as an inactive control. These bifunctional ligands deliver target proteins to the 26S proteasome near the AAA+ unfoldase pore, bypassing the requirement for E3 ligase-mediated target ubiquitination prior to degradation!
https://www.nature.com/articles/s41589-022-01218-w
Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
