Genotype #B3.13 #influenza #H5N1 viruses isolated from dairy #cattle demonstrate high #virulence in laboratory #models, but retain #avian virus-like properties, https://etidiohnew.blogspot.com/2025/07/genotype-b313-influenza-h5n1-viruses.html

Glutamic Acid at Position 343 in #PB2 Contributes to the #Virulence of #H1N1 #Swine #Influenza Virus in Mice, https://etidiohnew.blogspot.com/2025/07/glutamic-acid-at-position-343-in-pb2.html

🦠 Notre revue sur l'ensemble de l'épidémiologie et évolution du #COVID commandée par #Virulence est maintenant en ligne en #openaccess.

https://www.tandfonline.com/doi/full/10.1080/21505594.2025.2480633

🗞️ Il y a plus de 79.000 articles sur le sujet et nous n'avons « que » 300 citations, c'est un forcément un point de vue assez subjectif.

🦠 Our #review on all of #COVID #epidemiology and #evolution solicited by #Virulence is online on #openaccess

https://www.tandfonline.com/doi/full/10.1080/21505594.2025.2480633

🗞️ There are more than 79.000 articles on the topic and we "only" have 300 references, this is more like a perspective piece.

Different #genetic #determinants for high #virulence, #transmission and #replication of high pathogenicity #H7N7 avian #influenza virus in #turkeys and #chickens, https://etidiohnew.blogspot.com/2025/03/different-genetic-determinants-for-high.html

A comprehensive #review of current #insights into the #virulence factors of #SARS-CoV-2, https://etidiohnew.blogspot.com/2025/01/a-comprehensive-review-of-current.html

#Hemagglutinin with a #polybasic #cleavage site confers high #virulence on #H7N9 avian #influenza viruses, https://etidiohnew.blogspot.com/2025/01/hemagglutinin-with-polybasic-cleavage.html

Loin du #Sunset-Strip en #Californie, c'est à #Marseille sur les #plages du sud de la #France que se forme #RakelTraxx, un #groupe qui vient prolonger l'#héritage de leur aînés à l'instar des #MotleyCrue, #Poison et autres #PrettyBoyFloyd. #Rakel_Traxx réclame avec #virulence un retour certain aux valeurs essentielles du #glam-metal en proposant un #style décadent et empreint de #sleaze-rock.
https://www.youtube.com/watch?v=_mHLO5vR9ng

2 #aminoacid residues in N-terminal region of #polymerase acidic protein determine #virulence of Eurasian avian-like #H1N1 swine #influenza viruses in mice, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.01293-24?af=R

We identified that 2 naturally occurring aa mutations in PA derived from #H1N1/2009 are crucial determinants of virulence of rEA H1N1 viruses & revealed differential mechanism by which these 2 mutations affect transcription & replication of vRNA.

''It is noteworthy that crucial mutations associated with #mammalian #host #adaptation and enhanced #transmission, specifically residues 271A, 292 V, 591 K, 627 K/V/A, 701N, in PB2 (28, 30, 33-35), and 228S, along with the #virulence-increasing residue 66S in PB1-F2(46), were conspicuously absent in all #HPAI virus strains derived from dairy #cattle and #cats. ''

#Aminoacid #mutations #PB1-V719M and #PA-N444D combined with #PB2-627K contribute to the #pathogenicity of #H7N9 in #mice, Vet Res.: https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6

Overall, this study revealed that #virulence in H7N9 is a #polygenic trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

#Virulence and #transmission vary between #Usutu virus #lineages in #Culex pipiens https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012295

Therefore, we found evidence of lineage-specific differences in vectorial capacity and virulence to both the vector and vertebrate host which lead to balanced propagation of both viral lineages.

#Outbreaks of #H5N1 High Pathogenicity Avian #Influenza in #SouthAfrica in 2023 Were Caused by Two Distinct Sub-#Genotypes of Clade 2.3.4.4b Viruses, Viruses: https://www.mdpi.com/1999-4915/16/6/896

South African clade 2.3.4.4b H5N1 viruses had comparatively fewer #markers of #virulence and #pathogenicity compared to European strains, a possible reason why no #spillover to #mammals has occurred here yet.

Nipah Virus: Understanding the Threat and Staying Safe

#Isolation, #Virology, #Virulence, #Virus, #VirusInfection #Health, #Virology Introduction In recent years, the world has been plagued by a series of viral outbreaks that have sent shockwaves through…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/05/08/nipah-virus-understanding-the-threat-and-staying-safe/

Pathogenicity, Virulence And Infection

#Infection, #LD100, #LD50, #Pathogenicity, #Virulence #Microbiology Pathogenicity of any microbe is determined by the chances of developing a diseases. Various strains of same pathogen may have…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/05/03/pathogenicity-virulence-and-infection/

In #Ovo #Models to Predict #Virulence of Highly Pathogenic Avian #Influenza #H5-Viruses for #Chickens and #Ducks https://pubmed.ncbi.nlm.nih.gov/38675905/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240427100729&v=2.18.0.post9+e462414

@krypt3ia it is all natural - the real fear is with synthetic attentuation studies - 100x the depression factor and the really sad part is it probably already happened once, likely will happen again #woohan #virulence #unknowns

#PB2 residue 473 contributes to the #mammalian #virulence of #H7N9 avian #influenza virus by modulating viral #polymerase activity via ANP32A, J Virol.: https://doi.org/10.1128/jvi.01944-23

-- In this study, we identified PB2 residue 473 as a new determinant of mouse virulence and mammalian #adaptation of the viral polymerase of the H7N9 virus and its non-pathogenic #H9N2 counterparts.

When researchers tried to evolve a #yeast population to stick to plastic, they accidentally increased its ability to cause infection. What more can we learn about ‘accidental #virulence’? #Pathogens #Microbiology #Evolution https://elifesciences.org/articles/94556?utm_source=,astodon&utm_medium=social&utm_campaign=organic_insights

#StaphAureus lipoproteins play unique roles in cellular processes & host interactions. @SchilcherKatrin @Horswill_Lab reveal that #lipoprotein CamS represses toxin production, showing how lipoproteins can affect #virulence & disease outcomes #PLOSBiology https://plos.io/48Of5f3