🧬 Can molecular simulations transform the future of long-acting diabetes treatments?
🔗 In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.007
📚 CSBJ: https://www.csbj.org/
#MolecularDynamics #DiabetesResearch #Biotherapeutics #GLP1 #Albumin #DrugDelivery #Biomaterials #ComputationalBiology #ProteinEngineering
#Cannabis als #Lebensmittel – die Vorteile des Superfoods im Überblick!
Warum ist #Hanf als Lebensmittel so gesund?
Die #Hanfpflanze besteht wie der menschliche Körper zu 20 Prozent aus Proteinen.
Die #Proteine sind ähnlich wie beim Menschen überwiegend #Albumin & #Edestin. So kann der Mensch von Lebensmitteln aus Hanf enorm profitieren. ➡️ https://das-ernaehrungshandbuch.de/hanf-superfood/
#Hanfgeschichten #Bayern #WEEDMoB #marijuana
#Merz #Söder #Klingbeil #Reiche 😀 #SPD #CDU #CSU #Grüne #DIELINKE #FDP #cop30
#Cannabis als #Lebensmittel – die Vorteile des Superfoods im Überblick!
Warum ist #Hanf als Lebensmittel so gesund?
Die #Hanfpflanze besteht wie der menschliche Körper zu 20 Prozent aus Proteinen.
Die #Proteine sind ähnlich wie beim Menschen überwiegend #Albumin & #Edestin. So kann der Mensch vor allem von Lebensmitteln aus Hanf enorm profitieren. https://das-ernaehrungshandbuch.de/hanf-superfood/
#Hanfgeschichten #Bayern #WEEDMoB #marijuana
#Merz #Söder #Klingbeil #Reiche 😀 #SPD #CDU #CSU #Grüne #DIELINKE #FDP
Uncovering the Effects of Alcohol on Green Tea Polyphenols Release from Albumin Nanoparticles - #Albuminnanoparticles #anomaloustransport #dosedumping #greenteapolyphenols #similarityfactor #zeroorderkinetics #Albumin #nanoparticles #greentea #polyphenols #tea - https://link.springer.com/article/10.3103/S0095452725020082
💡 Our scientists discovered a new infection strategy in #Candida albicans: human #albumin reprograms its metabolism, turning harmless strains pathogenic – without the need of hyphae or toxins.
#NatCommun #LeibnizHKI
🗞️ Read our press release: https://lmy.de/mthFi or the
🧪 original publication in Nature Communications: https://rdcu.be/exl7d
@dfg_public
article from 2022:
Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836760/
related, from 2012:
Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands
https://pubmed.ncbi.nlm.nih.gov/22549788/
"Although serum albumin has an established function as a transport protein, evidence is emerging that serum albumin may also have a role as a molecular chaperone. Using established techniques to characterize chaperone interactions, this study demonstrates that bovine serum albumin: 1) preferentially binds stressed over unstressed client proteins; 2) forms stable, soluble, high molecular weight complexes with stressed client proteins; 3) reduces the aggregation of client proteins when it is present at physiological levels; and 4) inhibits amyloid formation by both WT and L55P transthyretin. Although the antiaggregatory effect of serum albumin is maintained in the presence of physiological levels of Ca(2+) and Cu(2+), the presence of free fatty acids significantly alters this activity: stabilizing serum albumin at normal levels but diminishing chaperone-like activity at high concentrations. Moreover, here it is shown that depletion of albumin from human plasma leads to a significant increase in aggregation under physiologically relevant heat and shear stresses. This study demonstrates that serum albumin possesses chaperone-like properties and that this activity is maintained under a number of physiologically relevant conditions."
research article from 2011:
Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy
https://www.nature.com/articles/labinvest201171
"Human serum albumin, the most abundant protein in plasma, serves as a transporter of various ligands and an antioxidant in blood circulation. Human serum albumin is a mixture of a reduced form (human mercaptalbumin: HMA) and an oxidized form (human nonmercaptalbumin: HNA). Albumin is the major antioxidant in plasma, and a large proportion of all the serum antioxidant properties can be attributed to albumin. Previous work has shown the total reactive antioxidant potential in plasma, considered as an index of the level of antioxidants, decreased in patients with FAP. In addition, more recent work demonstrated that albumin suppressed amyloid formation of amyloid-β(Aβ), a component of amyloid fibrils in Alzheimer's disease, by reducing oxidative stress. These data suggest that albumin functing as an antioxidant may perform a crucial role in amyloid formation in FAP."
Which Biomarkers Are Most Predictive Of Biological Age?
https://youtu.be/A8z-722SjFw?si=XeMdtO1Wi9KQAa30
#aging #biomarkers #albumin #HbA1c #BloodGlucose #adiponectin #lead #LymphocyteCount
I found that this #egg for #breakfast was cracked and in fact #frozen. So, after carefully removing the #shell, you can see the #yolk through the clear #albumin. Still, it made a good #omelette eventually.
I listened to a whole album and talked about it a little! https://dotmatrixwithstereosound.com/2024/01/albumin-david-holmes-presents-the-free-association/
@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!
Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?
Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?
@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1
https://link.springer.com/article/10.1007/s00134-022-06740-y
#Albumin Should Be Remembered When Patients With #SepticShock Are Resuscitated
“Although no significant difference in 28-day mortality rate or 90-day mortality rate was observed between the use of albumin and #crystalloids, #colloids appeared to be more effective than crystalloids in stabilizing hemodynamic end points”
I couldn't agree more. Sometimes you have to find what to do at the moment. It is safe and may help.
https://journal.chestnet.org/article/S0012-3692(23)00654-2/fulltext
