Okay, so I'm not switching completely to #teamtomo Helical reconstruction of #amyloids can be quite fun when you get beautiful structures like this! And thanks to @sjorsscheres.bsky.social for the suggestion of higher order symmetries, it was indeed the case 😉🧪🧬🧶

Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock

Scientists at @uni_mainz_eng & @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases // #neurodegeneration #amyloid #AgeingResearch #amyloids
https://nachrichten.idw-online.de/2024/06/17/a-new-way-to-measure-ageing-and-disease-risk-with-the-protein-aggregation-clock

Word Search Puzzle 972

Word List : #faute #reak #meraline #enabler #quashee #knurlin #amyloids #carrycot #disbar #tainted #bool #redries #crude #turves #bkpr #main #medias #dioxan

http://karafinance.com/2024/02/28/word-search-puzzle-972/

#Molecular cooperation at the threshold of #life.

#amyloids #nucleic_acids

https://phys.org/news/2023-11-molecular-cooperation-threshold-life.html

Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon; very grateful to present and past group members.
https://rdcu.be/dnaXd

Coming Thursday, we have a big review coming out about our work on #cryoEM structures of #amyloids in the past 6-7 years. I will promote on Twitter, Mastodon and BlueSky, and analyse interactions on the different platforms.

RT @ProteinSociety: The September newsletter is out, with thoughts about AI/ChatGPT, and choosing the right freezer for your research lab! Check it out here: https://lnkd.in/gR2xqfEu https://lnkd.in/gmEUGxGQ

#proteinscience #ai #chatgpt #proteindynamics #microscopy #amyloids #scientificwebinar https://lnkd.in/gR2xqfEu

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Related hashtags for this Long COVID discussion

#COVID19 #COVID #SARScov2 #LongCOVID #1918flu #PublicHealth #pandemics #LongFlu #SpanishFlu #PAIS #PostAcuteInfectionSyndrome #RiskAvoidance #RiskAversion #EllsbergParadox #amyloids #neurobiology #LewyBody #LewyBodies #neurodegradation #CellBiology #ParkinsonsDisease #parkinsonism #ProteinMisfolding #alphaSynuclein #synucleinopathy #synucleinopathies #DreamEnactmentSleepDisorder #SleepDisorders

“Investigating this further, the researchers found antibodies in the three patients that bound specifically to ATTR amyloid deposits in mouse and human tissue and to synthetic ATTR amyloid. No such antibodies were present in 350 other patients in the cohort with a typical clinical course.” #dna #Amyloids #isogg #geneadons #ucl https://medicalxpress.com/news/2023-06-devastating-heart-condition-reversed.html

I can highly recommend @WenjuanZhang11: she is a fantastic scientist and a wonderful person. Work with her on #cryoEM of yeast #amyloids!
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RT @WenjuanZhang11
We are recruiting a #postdoc to join our team @MRC_Prion at @ucl for studying #CryoEM structures of prion-like protein assemblies in neurodegenerative diseases and yeast model. More information and apply link are here: http://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details…
https://twitter.com/WenjuanZhang11/status/1630577935831662593

The identity of extra densities in #cryoEM maps of #amyloids from brains remains unknown, and a major focus of research. Just because a model fits in these fuzzy densities does not mean much, and writing speculative papers is going to be of little help.
https://www.biorxiv.org/content/10.1101/2023.02.01.526613v1

(It is in part a follow-up on our earlier collaborative paper, more focused on the #DNP #SSNMR analysis of unlabeled #polyQ #protein #amyloids - https://pubs.acs.org/doi/10.1021/jacs.8b09002 )

Most #Pseudomonas #aeruginosa strains encode functional #amyloids. However, the biological role of these #biofilm components have so far remained unknown. Here, we use a rat 🐀 model to show that they can br implicated in lung 🫁 infections. https://journals.asm.org/doi/10.1128/spectrum.03071-22

Just in case this leads to the suspension of my account, 👋#goodbye! I get most of my science (#cryoEM, #amyloids, #Alzheimers) and other news here; and am 🥰 grateful to my 12.5k followers for their interest. I would miss this all dearly, but there are limits...

“How important is the N-terminal acetylation of alpha-synuclein for its function and aggregation into #amyloids?” by @vinsub https://www.frontiersin.org/articles/10.3389/fnins.2022.1003997/full #amyloid #parkinsons