Interesting study in Nature for people with a family history of #dementia & #Alzheimers, #ApoE4 carriers, etc.
This doesn't come out of nowhere, researchers have previously noted somewhat lower dementia rates in areas with a lot of lithium in the water.
🔷 Lithium deficiency and the onset of Alzheimer’s disease
https://www.nature.com/articles/s41586-025-09335-x
10.1038/s41586-025-09335-x
Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
https://the-14.com/thirty-years-on-our-research-linking-viral-infections-with-alzheimers-is-finally-getting-the-attention-it-deserves/
A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
APOE4 gene may influence brain barrier function in early stages of Alzheimer’s disease https://www.psypost.org/apoe4-gene-may-influence-brain-barrier-function-in-early-stages-of-alzheimers-disease/?utm_source=dlvr.it&utm_medium=mastodon #AlzheimersDisease #APOE4 #brainbarrier #neurodegeneration #Alzheimersrisk
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On the same (general) topic: individual genetic susceptibility ...
Genes known to increase the risk of Alzheimer's may actually be an inherited form of the disorder, researchers say
https://www.ctvnews.ca/health/genes-known-to-increase-the-risk-of-alzheimer-s-may-actually-be-an-inherited-form-of-the-disorder-researchers-say-1.6943195
https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
https://www.nature.com/articles/s41591-024-02931-w
Study Suggests #Genetics as a Cause, Not Just a Risk, for Some #Alzheimer’s
People with two copies of the #gene variant #APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such #patients could be diagnosed years before symptoms.
https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html
https://archive.ph/yTtsM
A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers
The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.
I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.
#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure
#Alzheimer-Forschung und die Entdeckung der Bedeutung des #APOE4 Gens: >>[...]die Ergebnisse würden die Art und Weise ändern, wie Forscher über Alzheimer denken und wie sie die Krankheit erforschen. Sie verankerten APOE4 »als kausalen Faktor von Alzheimer, und nicht nur als Risikofaktor.« Es sei dringend notwendig, ein Medikament zu entwickeln, das speziell darauf abziele.
Alfredo Ramírez, Leiter der Sektion Molecular Neuropsychiatry an der Uniklinik Köln, überzeugen die Ergebnisse: »Es gibt nicht mehr viel zu tun, um APOE4 als monogene Form der Alzheimer-Krankheit zu betrachten.« Als monogen werden Erkrankungen bezeichnet, die durch eine Mutation in einem einzelnen Gen ausgelöst werden, bekannt sind sie auch als Ein-Gen-Krankheiten. Es müsse aber unter anderem noch korrekt bestimmt werden, wie hoch für Menschen mit zwei APOE4-Genen die Wahrscheinlichkeit tatsächlich sei, an Alzheimer zu erkranken.<< https://www.msn.com/de-de/gesundheit/other/alzheimer-menschen-mit-dieser-mutation-bekommen-die-krankheit-fast-immer/ar-BB1lXwle?ocid=Bing
Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor
#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome
Die Genvariante #APOE4 ist nicht nur Risikofaktor für #Alzheimer sondern könnte laut einer Studie in Nature Medicine eine genetische Form der Erkrankung sein. Unabhängige Forschende finden die Ergebnisse überzeugend: https://www.sciencemediacenter.de/alle-angebote/research-in-context/details/news/apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung/?mtm_campaign=mastodon&mtm_kwd=apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung
Select cases of Alzheimer's may be linked to carrying two copies of a gene in new research #alzheimers #research #study #memorycar #dementia #gene #apoe4 #genetics #dna
https://fullsteamahead365.com/2024/05/07/alzheimers-may-be-linked-to-two-copies-of-gene/
Via #ABC News
Scientists have long known a #gene called #APOE4 is one of many things that can increase people’s risk for #Alzheimers, including simply getting older. The vast majority of Alzheimer’s cases occur after age 65. But #research published Monday suggests that for people who carry not one but two copies of the gene, it's more than a risk factor, it's an underlying cause of the mind-robbing #disease.
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
📍Today that changed to nearly 100% full penetrance
Buenas noticias, nueva avenida terapéutica para prevenir el desarrollo de la Enfermedad de #Alzheimer, incluso (sobre todo) en portadores de #ApoE4
En los próximos años habrá nuevos intentos de tratamiento, excelentes noticias!
I was not aware of this previously, but it's thought #APoE4 was the only common APoE allele until fairly recent in hominid evolution, despite it seeming to be disadvantageous today
Common Alzheimer’s disease gene may have helped our ancestors have more kids
Study of traditional society in Amazon suggests why evolution hasn’t purged harmful variant
https://www.science.org/content/article/common-alzheimer-s-disease-gene-may-have-helped-our-ancestors-have-more-kids
#alzheimers #genetics #population #APOE4
看到 #大聪看电影 中提到纪录片 #克里斯·海姆斯沃斯：挑战极限 中为 #锤哥 做的体检，其中有对 #APOE4 基因的检测，这是一项关于 #阿兹海默症 患病风险的检测。
