Lmst

🧬 Breaking: New insights into autism reveal hidden genetic clues using yeast & fruit flies! 4 MECP2 variants discovered, challenging our understanding of neurodevelopmental disorders 🔬 #Genomics #ScienceBreakthrough #AutismResearch https://emmecola.github.io/genomics-daily

What if autism begins not in childhood, but in a dish? Japan’s scientists may have just unlocked that door. #Neuroscience #AutismResearch #CRISPR

https://geekoo.news/autism-in-a-dish-a-new-genetic-toolkit-for-brain-research/

🧬 Why do humans think so differently from Neanderthals? The answer might lie in gene switches, not the genes themselves.

🔗 Evolution is in the details: Regulatory differences in modern human and Neanderthal. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.052

📚 CSBJ: https://www.csbj.org/

#Genomics #Neuroscience #Evolution #HumanOrigins #NeanderthalDNA #AutismResearch #HumanEvolution #GeneRegulation #Bioinformatics #ASD #RegulatoryGenomics #TranscriptionFactors

Evolution is in the details: Regulatory differences in modern human and Neanderthal. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.052

🧬 Cracking the ASD code! Ueno et al. reveal hidden genetic clues using innovative clustering-based GWAS, offering new hope for understanding autism's complex landscape. 🧩 #Genomics #AutismResearch #PrecisionMedicine https://emmecola.github.io/genomics-daily

https://neurosciencenews.com/dna-methylation-serotonin-asd-29112/

Of *course* we have "abnormal" methylation of certain genes. /s

That aside, this article appeared relatively low on ableist language. My biggest reason for sharing it:

"Notably, immune activation and exposure to stress hormones are known to alter neuronal activity in the dorsal raphe (DR, a region of the brain involved in serotonin signaling), contributing to ASD development."

#ActuallyAutistic
#autism
#AutismResearch
#genetics
#methylation
@actuallyautistic

I’ve been confused (read: unconsciously annoyed) by this research from Yale I recently came across:

https://medicine.yale.edu/news-article/a-key-brain-difference-linked-to-autism-is-found-for-the-first-time-in-living-people/

Intuitively, their methods and conclusions feel wrong. This is not my field of expertise so I’m out of my depth, but my gut and brain are nagging me something is off.

Not to mention my lived experience with hyper sensitivity, hyper brain plasticity, hyper activity, hyper focus, hyper intelligence*, and hyper memory don’t seem to logically point to…*less* synapses?

Anyway, hard to find substantial reviews or serious context, so curious to hear about any.

*) like most autistic people, I’m more intelligent than the general population. A fact much “cure”/disorder focused research very surprisingly keeps forgetting to mention.

#ActuallyAutistic #AutismResearch

This could get really bad. If you are a neurodivergent American and don't have a passport, apply for one TODAY!

Fascism demands a level of conformity that is impossible for most of us.

#GetYourPassport
#autism
#AutismResearch
#AutismResearcher
#AutismResearchers
#ActuallyAutistic
#prejudice
#DisabilityRights

@hosford42 @actuallyautistic

"high autistic-like trait burden"

"'rescued' low-social monkeys’ ability to respond prosocially"

"at risk of developing social deficits related to autism"

This is language from an actual paper on rhesus monkeys being used to model autism.

Burden. Rescue. Risk. Deficit.

How do these people not recognize that their language is chock full of value judgments? Value judgments don't belong in science, where conclusions are supposed to be based on objective fact.

They've already made up their minds about us. Put another way, they've already made judgments ahead of time. That is, they've already pre-judged us. Or, the most blatantly recognizable way to put it: They are prejudiced.

#autism
#AutismResearch
#AutismResearcher
#AutismResearchers
#ActuallyAutistic
#prejudice
#DisabilityRights

@actuallyautistic

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

We will be presenting a free webinar on April 24th at 7.30pm UK time to explore the findings of our new paper on improving Substance Use services for Autistic adults. The papers authors will hold a live discussion of the findings and answer some questions from the audience. To register, go here-

https://www.eventbrite.co.uk/e/improving-substance-use-treatment-for-autistic-adults-tickets-1315555173939

#ActuallyAutistic #autism #Autistic #AutismResearch #SubstanceUse #Addiction #MentalHealth @mentalhealth@newsmast.community @mentalhealth@a.gup.pe @neurodiversity @actuallyautistic @autisticadvocacy

Breakthrough study reveals how MDGA2 protein deficiency disrupts brain signaling, leading to autism-like behaviors in mice. Could this be the key to new ASD therapies? #AutismResearch #Neuroscience #ASD

https://geekoo.news/unraveling-autism-the-role-of-mdga2-in-brain-signaling/

Study CBD-Rich Cannabis Offers Potential Benefits For People With Autism Spectrum Disorder https://share.newsbreak.com/cbxkxsyh?s=i0 #cbd #cannabisresearch #autismresearch #autism #AlamogordoTownNews

AI reveals we're looking at autism diagnosis all wrong—it's not social skills, but repetitive behaviors that matter most. #AutismResearch #AIinMedicine #Neurodiversity

https://geekoo.news/ai-redefines-autism-diagnosis-repetitive-behaviors-take-the-lead/

On 7 March, the Netherlands Women’s Health Research & Innovation Center will open at Erasmus MC! 🎉

I’m honoured to be speaking alongside neuroscientist Stéphanie Dijkhuizen, where we’ll introduce the SCANNER project—an initiative tackling 1 of the most critical questions in autism research:

✨ (why) are there more men than women with autism? ✨

#Neurodiversity #AutismResearch #SCANNER #WomenInScience #ErasmusMC #Autism #ClosingTheGap #NeuroScience #Neuroscientist #ActuallyAutistic #womeninstem

There's not a lot of #research (yet) about older Autistic folks, so I thought this project was interesting:

If you're diagnosed or self-diagnosed AND in the UK, Luxemburg or Germany, and you want to add to the data, you can fill out a

"Questionnaire about Quality of life for Autistics aged 40+"

https://www.soscisurvey.de/aqol/

#autismResearch #actuallyAutistic #AutismusForschung #Aging #Research

As a translator, what I mostly think about is failure. I have paralysing fear of being perceived as flawed. Maybe it comes from always having felt less than and different (I'm #ActuallyAutistic).

Maybe the question I should be asking myself is: How can I keep working as a translator?

#ActuallyAutistic #Neurodivergent #MentalHealth #xl8 #Neurodiversity #AutismResearch

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