#PaleMoon will be requiring #AVX support in CPUs for its official binaries starting from version 33.3.0, which can be expected to release on the second Tuesday of this August.
For those still stuck with #SSE2 you will either have to upgrade your processor to something more recent (AVX support has been commonly available for 10 years now) or switch to a community build that still builds support for SSE2.
https://forum.palemoon.org/viewtopic.php?f=1&t=31399
EDIT: Oh and I forgot to mention too that this is only for 64-bit. 32-bit Windows binaries will still support SSE2 (there are not 32-bit only processors that supports AVX as far as I know anyway, and even if there are it would most likely result in worse performance due to how 32-bit x86 and AVX work)