Lmst

Bacteriophage

#art #abstractart #painting #bacteriophage

This is a highly detailed, abstract image composed of numerous overlapping, circular and amoebic shapes. The image is divided into two main color fields: a predominantly teal and blue area on the left, and a predominantly orange and yellow area on the right. These color fields are not sharply delineated but blend and intersect with each other. Each shape is outlined in a darker tone, creating a stained-glass effect.

#biology #medicine #phages #EscherichiaColi

An article published in the journal "Microbiology Spectrum" reports the results of experiments based on the use of genetically modified #bacteriophage #viruses to combat strains of Escherichia coli #bacteria that developed resistance to various antibiotics. These findings offer a way to neutralize these bacteria and new insights into the interactions between bacteriophages and bacteria.

https://english.netmassimo.com/2025/11/12/a-technique-based-on-the-use-of-genetically-modified-bacteriophage-viruses-to-fight-strains-of-bacteria-that-developed-resistance-to-antibiotics/

Understand bacterial genetics and gene transfer mechanisms driving diversity and resistance. #BacterialGenetics #Microbiology #GeneTransfer #Transformation #Transduction #Conjugation #Transposition #Plasmids #Bacteriophage #AntibioticResistance #USMLE #MedicalEducation #ClinicalMicrobiology #Genetic

https://mymedschool.org/portfolio/u01-03-015-bacterial-genetics/?utm_source=mastodon&utm_medium=jetpack_social

🦠 Phage protein mystery solved! Empathi tool cracks the code, doubling our understanding of viral protein functions. Genomic detective work at its finest! 🕵️‍♀️ #Bacteriophage #GenomicInnovation #ScienceBreakthrough https://emmecola.github.io/genomics-daily

Imagine running #arch #linux on a #bacteriophage also playing #doom on said bacteriophage

#shitpost

A precursor procapsid is initially formed during #bacteriophage assembly, but how? The #cryoEM structure of the scaffolding protein complex & portal within #phage P22 procapsid reveals how this complex orchestrates the initiation of procapsid assembly @PLOSBiology https://plos.io/44B71iE

Structural comparison of the portal–tail complex in the P22 mature virion and the procapsid. Top left and top middle: Overall and cut-open views of the P22 mature virion (EMD-61453). Top right: Zoomed-in view of an atomic model of the portal–tail complex in the mature virion (PDB ID: 9JG6). Bottom left and bottom middle: Overall and cut-open views of the P22 procapsid (EMD-61454). Bottom right: Atomic model of the portal in the procapsid (PDB ID: 9JGA).

@farbel @Black_Flag A medical example: Phage therapy, pioneered in the USSR.

https://en.wikipedia.org/wiki/Phage_therapy

#socialism #communism #marxism #capitalism #PhageTherapy #bacteriophage

We have a new preprint describing a method for #bacteriophage phylogenetics and comparative genomics.

Maybe useful for those interested in all the amazing #phages out there and their bizarre mosaic genomes

Towards a unifying phylogenomic framework for tailed phages

https://www.biorxiv.org/content/10.1101/2024.10.21.619452v1.abstract

#viruses #microbiology

1915,1917: Frederick Twort & Félix d’Herelle discovered bacteriophages, virus that prey on bacteria. #Poetry #Science #History #Virology #Bacteriophage #Twort #d’Herelle (https://sharpgiving.com/thebookofscience/items/p1915b.html)

Drawing of a bacteriophage, with looks a bit like a lunar lander.

Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [4 / 4]

. .. Once they have the right phage or series of phages, and FDA approval is obtained, the phage is used and can be delivered through inhalation, injection, or ingestion.

#Yale #research #bacteriophage

Article also discusses

Reducing the spread of AMR in the hospital

Pathogens in the pipes

“Care Signature pathways,” to guide clinical decision making, including decision involving antibiotics.

Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [3 / 4]

They categorize and store these phages to create a “phage library” of potential candidates for phage therapy. To treat patient infections, a bacterial sample is obtained from patients and tested by the phage library to identify which phages are best suited to kill the bacteria in question.

#Yale
#research
#medecine
#bacteriophage

Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [3 / 4]

They categorize and store these phages to create a “phage library” of potential candidates for phage therapy. To treat patient infections, a bacterial sample is obtained from patients and tested by the phage library to identify which phages are best suited to kill the bacteria in question.

#Yale #research #medecine #bacteriophage

Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [2 / 4]

This was made possible through the Food and Drug Administration’s (FDA) expanded access pathway, which allows for the use of experimental treatments in life-threatening conditions when no other comparable treatments exist

Through a process called “phage hunting,” the research team looks for clinically relevant phages both locally and around the world.

#medecine #Yale #research #bacteriophage

Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More
October 31, 2024 by Eva Cornman

https://medicine.yale.edu/news-article/antibiotic-resistance-fighting-a-global-threat-with-phage-hunting-and-more/

Led by Paul E. Turner, PhD, Rachel Carson Professor of Ecology and Evolutionary Biology, the Center for Phage Biology and Therapy at Yale has been using bacteriophages (phages for short) to treat infections caused by multidrug-resistant bacteria since 2013.

#Yale #research #medecin #bacteriophage

[1 / 4]

'dangerous #Merri lurker' (Merri-merri-uth nyilam marra-natj in #woiwurrung might be useful in treating bacterial infections.

#Bacteriophage
https://www.friendsofmerricreek.org.au/bacteriophage

#AntiMicrobialResistance
https://www.monash.edu/impact-amr

Bacteriophage Virions
https://pmc.ncbi.nlm.nih.gov/articles/PMC8269216/

#firstnations #Wurundjeri
https://www.wurundjeri.com.au/

Drawing by Dr Eleanor Jameson

Merri-meeri-uth nyilam marra-natj (MMNM)

This phage makes surprise encounters with its prey (bacteria).

It uses its short bulbous legs to make contact with the bacteria.

These legs help it bury into the bacteria's surface and trigger the phage to contract like a spring. In this crouched position, it kills the bacteria.

Merri-merri baany-a bundha-natj (MMBB)

The second phage was named Merri-merri baany-a bundha-natj (MMBB), which translates as “Merri water biter.” This phage moves like a snake to strike its prey (bacteria). It chews into the bacteria, then replicates inside the bacteria and releases its progeny into the creek water.

Drawing by Dr Eleanor Jameson

Bacteriophages (red) are the natural predators of the much larger bacteria (blue). Photograph from iStock

21y after collecting data during my PhD, we got to publish the structure of RNA-dependent RNA polymerase from #bacteriophage phi8!
Unsolvable in 2003 but #AlphaFold2 model worked!

https://www.nature.com/articles/s41598-024-75213-7

Lesson learned: never discard data!

Great job Kamel El Omari getting it over the line!

"The number of viruses that we found is absolutely wild. We found many viruses that we know very little about and many others that we have never seen before. It's amazing how much untapped biodiversity is all around us. And you don't even have to go far to find it; it's right under our noses," said Dr Erica M. Hartmann.

#microbiology #bacteriophage #biology #research #science #nature

https://www.labroots.com/trending/microbiology/27892/world-mysterious-microbes-on-toothbrush

i did a Summer internship studying homing introns in college. big advance!

"This work demonstrates how a homing endonuclease can be deployed in interference competition among viruses and provide a relative fitness advantage. Given the ubiquity of homing endonucleases, this selective advantage likely has widespread evolutionary implications in diverse plasmid and viral competition as well as virus-host interactions."

#homing #endonuclease #phage #bacteriophage #virus

https://www.science.org/doi/10.1126/science.adl1356