GPR1 is a #chemerin receptor, but is Gi signaling elicited upon binding to the chemerin #adipokine? The #cryoEM structure of the GPR1-Gi complex bound to chemerin confirms Gi signaling and a ‘two-site’ activation mechanism #PLOSBiology https://plos.io/4hr0s6a

The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd