#coccidioides

Bich Nguyen :verified:bicmay@med-mastodon.com
2025-10-05

"The infrastructure supporting everyone Galgiani works with — the research to develop a vaccine that may one day become widely available for human use, the valley fever surveillance tools that rely on government weather data to operate, and the federal funding that pays for Arizona’s public health initiatives, public universities, and research labs — is starting to wobble."

grist.org/health/valley-fever-

#PublicHealth #IDmastodon #coccidioides #cocci #ValleyFever #vaccines #immunizations #research

2025-10-03

In #Arizona, a fight against a deadly #fungus is under threat from #Trump’s health policies

What one doctor’s quest to stop #ValleyFever says about America’s preparedness for climate-driven disease.

by Zoya Teirstein, October 2, 2025

Excerpt: "Valley fever is endemic to southern #WashingtonState, #Oregon, #California, #Nevada, #Utah, #NewMexico, #Texas, and parts of #CentralAmerica and #SouthAmerica, but nowhere are cases of the disease more common than in Arizona. After Arizona started mandatory laboratory reporting for valley fever in 1997, registered cases ticked up and down. But the number began trending upward dramatically in 2016. Then, in 2024, cases in the state exploded, hitting their second-highest total ever. More than 15,000 infections were reported — a 37 percent increase over 2023. California, which runs just behind Arizona in its annual valley fever caseload, registered a record-breaking 12,637 cases in 2024, representing a 39 percent increase over the previous year, which had already smashed a record set in 2019.

"Some portion of the rise in reported cases represents growing awareness among physicians and an associated surge in testing. The pace of new construction in #UntouchedAreas also plays a role.

"But the recent increase in cases has been so dramatic, Galgiani and other researchers across the West who study the fungus think another factor may be driving the trend: #supersoaker winter #monsoons followed by scorching summer #heat and #drought, a cycle made more intense by #ClimateChange.

"Because warmer air holds more moisture, monsoons and other major rainfall events pull in larger quantities of water vapor and produce heavier downpours as the planet warms. This physical fact has fueled a spate of #MonsterFloods across the U.S. and around the world in recent years. But the same warmth can conversely lead to drought by making the atmosphere 'thirstier,' or capable of absorbing more water from the land’s surface. Both conditions facilitate the spread of valley fever — the wetter conditions by encouraging growth of the #spores, and the drier by facilitating desiccation and soil disturbance.

" 'The main driver for us is certainly this very clear association for #coccidioides between heavy precipitation cycles followed by drought,' said George Thompson, a professor of medicine at the University of California, Davis, School of Medicine who specializes in #FungalDiseases.

"And it’s not just valley fever that may increase its spread thanks to climate change. Peer reviewed research shows that fungal threats of all kinds are poised to emerge and thrive in a warming world."

grist.org/health/valley-fever-

#ExtremeWeather #ClimateCrisis #Disease

2025-05-06

#Superbugs #Coccidioides

From CNN.com: The next superbug threat is already here. It’s going to be even harder to overcome

cnn.com/2025/05/06/health/fung

2025-04-22

Coccidioides is a fungal #pathogen that forms a unique structure, the spherule. This transcriptomic study of #Coccidioides development reveals spherule-specific gene regulation, Ryp1-dependent virulence factors, and potential #antifungal therapeutic targets @PLOSBiology plos.io/4cINMpl

Top: Micrographs of fixed samples from each flask at the time of RNA harvest. Endospore release was first observed on day 3. Bottom: Schematic of Regulation of gene expression in Coccidioides development. The data uncover regulatory modules in Coccidioides development. The majority of Coccidioides transcription factors (TFs), depicted as triangles in the figure, show enhanced expression in spherules compared to hyphae. These TFs, along with RYP1 (green hexagon) and a second regulator whose motif is reported here, guide the expression of endospore-associated transcripts and secreted effectors, including proteases. RYP1 also controls a core regulon, that is, expressed in both spherules and hyphae via a canonical RYP1 motif. Finally, in arthroconidia, RYP1 impacts the transcriptome, but likely through indirect regulation of one or more additional key regulators.
deewanideewani
2024-07-31

Clickbait headline. “Spread” implies contagion but body of article: “This infection, primarily found in Arizona and California, is not contagious, meaning it cannot be transmitted from person to person, health officials said.”

From: @glnews_mirror
mastodon.hongkongers.net/@glne

2023-04-01

Impact and Control of Valley Fever: Proceedings of a Workshop–in Brief
National Academies of Sciences, Engineering, and Medicine. 2023. Washington, DC: The National Academies Press. doi.org/10.17226/26928 #Coccidioides #ValleyFever #fungi #ThinkFungus

Ilan Schwartz :budding_yeast:GermHunterMD@med-mastodon.com
2022-11-21

Wow 🤩🤯

We now have a rupturing #Coccidioides spherule emoji :cocci:

@nick you continue to outdo yourself!
#ValleyFever #Coccidioidomycosis #Mycology @MSG_ERC

Rupturing spherule releasing endospores

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