#coccidioides

2025-05-06

#Superbugs #Coccidioides

From CNN.com: The next superbug threat is already here. It’s going to be even harder to overcome

cnn.com/2025/05/06/health/fung

2025-04-22

Coccidioides is a fungal #pathogen that forms a unique structure, the spherule. This transcriptomic study of #Coccidioides development reveals spherule-specific gene regulation, Ryp1-dependent virulence factors, and potential #antifungal therapeutic targets @PLOSBiology plos.io/4cINMpl

Top: Micrographs of fixed samples from each flask at the time of RNA harvest. Endospore release was first observed on day 3. Bottom: Schematic of Regulation of gene expression in Coccidioides development. The data uncover regulatory modules in Coccidioides development. The majority of Coccidioides transcription factors (TFs), depicted as triangles in the figure, show enhanced expression in spherules compared to hyphae. These TFs, along with RYP1 (green hexagon) and a second regulator whose motif is reported here, guide the expression of endospore-associated transcripts and secreted effectors, including proteases. RYP1 also controls a core regulon, that is, expressed in both spherules and hyphae via a canonical RYP1 motif. Finally, in arthroconidia, RYP1 impacts the transcriptome, but likely through indirect regulation of one or more additional key regulators.
deewanideewani
2024-07-31

Clickbait headline. “Spread” implies contagion but body of article: “This infection, primarily found in Arizona and California, is not contagious, meaning it cannot be transmitted from person to person, health officials said.”

From: @glnews_mirror
mastodon.hongkongers.net/@glne

2023-04-01

Impact and Control of Valley Fever: Proceedings of a Workshop–in Brief
National Academies of Sciences, Engineering, and Medicine. 2023. Washington, DC: The National Academies Press. doi.org/10.17226/26928 #Coccidioides #ValleyFever #fungi #ThinkFungus

Ilan Schwartz :budding_yeast:GermHunterMD@med-mastodon.com
2022-11-21

Wow 🤩🤯

We now have a rupturing #Coccidioides spherule emoji :cocci:

@nick you continue to outdo yourself!
#ValleyFever #Coccidioidomycosis #Mycology @MSG_ERC

Rupturing spherule releasing endospores

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