Fanboy moment for me today at #FocusOnCovalentDrugs. Hearing Matthias Gehringer present for the first time. His reviews on covalent warheads are a must-read in my group for many years now.

#Chemistry #ChemBio #DrugDiscovery #covalent

https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01153
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01825

Fanboy moment for me today at #FocusOnCovalentDrugs. Hearing Matthias Gehringer present for the first time. His reviews on covalent warheads are a must-read in my group for many years now. #ChemSky #ChemBio #DrugDiscovery #covalent pubs.acs.org/doi/10.1021/... pubs.acs.org/doi/10.1021/...

Emerging and Re-Emerging Warhe...

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors. #ABPP #ChemSky #ChemBio

Great keynote lecture by Marta Artola of the @LED3hub at #Lunteren. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked #covalent and non-covalent #inhibitors and #probes.
#chemistry #ChemBio
https://pubs.acs.org/doi/10.1021/jacs.2c05666

Great keynote lecture by @martola.bsky.social of the @led3hub.bsky.social at #Lunteren. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked #covalent and non-covalent #inhibitors and #probes. #chemsky #ChemBio pubs.acs.org/doi/10.1021/...

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Explore unprecedented binding sites on protein targets by screening #covalent heterocyclic MiniFrags. See how they work identifying novel #allosteric sites on HDAC8 https://is.gd/CdPLih

Thanks @EnamineLtd
for making the covalent MiniFrags available https://is.gd/7LN1sb

#fragments #FBDD #chemoproteomics #drugdiscovery

Thrilled to share our story on the first rationally designed #covalent #HDAC inhibitor! YSR734 uses an SNAr-reactive electrophile to engage a noncatalytic nitrosylation site cysteine in #HDAC2, showing in vitro activity in AML & #DuchenneMuscularDystrophy!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01236

Zum Glück sind wir schon aktiv - ich bin gerade in Australien zu Rohstoffen mit einer deutschen Wirtschaftsdelegation, auch Vertreter @MercedesBenz, und vor Ort bei #Covalent Lithium. Dort bestehen noch Investitionspotentiale. Now up to you!
https://www.spiegel.de/wirtschaft/unternehmen/e-mobilitaet-mercedes-chef-ola-kaellenius-draengt-politik-zu-neuer-rohstoff-strategie-a-cb4cfd4b-cf97-442c-8538-b5340248a931?sara_ref=re-so-wa-sh

🐦🔗: https://n.respublicae.eu/fbrantner/status/1643983958328369156

#JournalClub summaries of the CCC group meetings are now available online - just click the topic of your interest https://www.h-its.org/research/ccc/events/ The first slide deck from Dr. Michelle Ernst is on #intermolecular #covalent #interactions More to come on bonding & interactions!

Great to see this paper by the groups of @mariovdstelt and Nathaniel Martin with first authors Alexander Bakker and Ioli Kotsogianni out in JACS. Exciting chemical biology and medicinal chemistry research to identify a new #covalent #antibiotic with activity in MRSA. @LED3hub https://doi.org/10.1021/jacs.2c10819

Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author

Interesting work by Samy Meroueh @IUMedSchool on the development and characterization of reversible #covalent cyanamide antagonists of TEAD-YAP1 that engage a conserved cysteine palmitoylation site in #TEAD.
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.2c01189

@Artanicus funny but not really because you are looking to attack the #coronavirus lipid bi-layer (w proteins inside) which is actually very tough
- way to do that is #saponification which would be by lye (#sodiumhydroxide) attacking the actual lipids
- or the soap benefit from saponification which is the #covalent attraction of lipid side of #soap
- or, my hypothesis, actually attach it to fully-covalent mineral oil aka #babyoil until you can get to soap, or coconut oil