interessante Veröffentlichung zum Thema LongCovid, MECFS bzw. Brainfog: >>Langfristig können entzündliche Prozesse im Endothel zu Fibrose, Organschäden und mikrovaskulären Durchblutungsstörungen führen. Diese Veränderungen stehen im Zusammenhang mit Symptomen von Long COVID, wie kognitiven Beeinträchtigungen ("Brain Fog"), chronischer Müdigkeit und kardiovaskulären Problemen. Studien zeigen, dass bis zu 40 % der COVID-19-Genesenen eine anhaltend reduzierte Herz-Kreislauf-Kapazität aufweisen.<< https://www.dmz-news.eu/2024/12/01/endotheliale-entz%C3%BCndung-bei-covid-19-neue-erkenntnisse-zur-krankheitslast-und-langzeitfolgen/
Die Quelle dazu ist folgende Studie:
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Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
Peter Libby Authors Info & Affiliations
Science
28 Nov 2024
Vol 386, Issue 6725
pp. 972-973
DOI: 10.1126/science.add2962
#Endothelial #inflammation #DOI #science #covid19 #brainfog #longcovid #mecfs
#endothelial
Endothelial inflammation in #COVID19 | Science https://www.science.org/doi/10.1126/science.add2962 “Infection with severe acute respiratory syndrome coronavirus 2 (#SARSCoV2) has highlighted how altered #endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with ##LongCovid.”
#atherosclerosis occurs when #cholesterol and other fats form plaque on #arterywalls. This restricts #bloodflow & damages #endothelial cells on the inner surface of #bloodvessels. #lycopene and #phenolicacids can lower cholesterol levels #tomatoes are rich in lycopene & #vitamine
Uncovering the role of #FOXO1 in #vascular #development and #transcriptional dynamics in #endothelial cells.
https://phys.org/news/2024-03-uncovering-role-foxo1-vascular-transcriptional.html
New Approach To Stopping Diabetic Blood Vessel Damage: An enzyme inhibitor drug stops vessel lining damage in the retina, kidneys, and other sites. #diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol
https://www.instagram.com/p/C3Gd8J9LAmk/
https://medicalxpress.com/news/2024-02-epigenetic-status-metastasis.html
Decided to peek into msm news land on #AppleNews & found this article on #epigenetic status on #metastasis
Within it there was a link to #endothelial which nicely indexed by time any articles referencing it & the titles were pretty telling
https://medicalxpress.com/tags/endothelial+cells/
How many people are going to put 2 & 2 together tho?
@Brad @ddmgmgh
Kind of like #MitchMcConnel ?
Knew it was somehow related to his constant exposure to #Covid but thought it was #vascular #stroke #endothelial related… but why not all of it?
I’m tangent queen in active convo but can always get back to my original thought..
What this study & irl shows me the mass numbers will be seen first in the 40-80 group & 20-30 will follow after enough⏱️ #reinfection
https://archive.ph/2023.07.03-135424/https://www.popularmechanics.com/science/health/a44372622/why-does-hair-turn-gray/
& for final #AppleNews subscriber only content… they had to go back to July 3 to find a paywalled article😂
#Grayhair… it’s probs just genetics! I mean it MIGHT be various ailments like #heartdisease #Alzheimers but it’s PROBS not! What #telomeres you say? Pshaw. What’s that? Is that even real? Oh, but plucking out your gray isn’t good. Don’t do THAT whatever you do. What you say? #Covid19 causes #vascular #endothelial issues? Puh, as if🙄that would contribute🙄 to graying
August's most-read Tools paper presents an #optogenetic toolbox to reversibly control Rho #GTPase activity for manipulating the barrier between #endothelial cells: https://elifesciences.org/articles/84364?utm_source=mastodon&utm_medium=social&utm_campaign=submissions_organic
Oh to be in my 30’s again… #noThankYou
When you’re 33 & 37 you have less wear & tear on your #endothelial system so you’re not going to notice any real issues immediately which is how the #30something are somewhat fine for most part..for now
For these people, it’s #JustACold but all the #CovidPapers say quite differently. Amazingly haven’t read 1 study saying it does no harm🤔 Also amazingly I don’t think I’ve ever listened to an entire Taylor Swift song…& it’s not like I abhor pop or anything🤷🏻♀️
elevated #vascular #endothelial cell turnover and #erythropoiesis in #asymptomatic #COVID19 patients | https://www.biorxiv.org/content/10.1101/2023.07.28.550957v1 “Asymptomatic patients had elevated levels of immune-derived cfDNA but did not show evidence of #pulmonary or #cardiac damage. Surprisingly, these patients showed elevated levels of vascular endothelial cell and erythroblast cfDNA, suggesting that sub-clinical vascular and erythrocyte turnover are universal features of COVID19, independent of disease #severity.
Gene Expression: How their environment influences #endothelial cells. https://elifesciences.org/articles/88248?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights
Blood endothelial #ALK1-#BMP4 signaling axis regulates adult hair follicle #stemcell activation
Kefei Nina Li, Doina Tumbar et al
Blood vessel #endothelial cells form a #quiescence-inducing signaling niche for skin stem cells
What happens downstream of transcription factor #Prox1 during #transdifferentiation of embryonic venous #endothelial cells (VECs) into #lymphatic endothelial cells (LECs)?
Benjamin Hogan and colleagues use #singlecell profiling to reveal regulation of early events in #zebrafish #lymphangogenesis
⤵️
https://doi.org/10.1182/blood.2021012250
"Due to widespread #endothelial dysfunction and thrombosis, #COVID19 has the ability to affect nearly any organ. Pulmonary disease, specifically ARDS, may be driven in large part by vascular dysfunction & #microvascular thrombosis. Increased thrombotic events, most notably venous #thromboembolism but also myocardial infarction and stroke, have been reported. Vascular dysfunction may contribute #neurologic, renal & dermatologic manifestations
as well as #pacs & #misc "
Origin of #endothelial #cells constituting the vascular niche for hematopoietic stem and progenitor cells in #zebrafish.
https://phys.org/news/2023-01-endothelial-cells-constituting-vascular-niche.html
#Ebola virus disrupts the inner #blood-retinal #barrier by induction of vascular #endothelial growth factor in pericytes https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011077
Going uner the knife tomorrow morning for a cornea transplant to treat Fuchs' Dystrophy. Grateful for modern medicine.
#surgery, #endothelial, #keratoplasty, #cornea, #transplant, #DMEK, #fuchs, #dystrophy, #ophthalmology