AI Wristband Calms Essential Hand Tremors: the device yields a 3 fold improvement in daily task performance. #essentialtremor #ai #wristband #electrical
https://www.instagram.com/reel/DIxJktKs5gR/
#essentialtremor
@axoaxonic
Holly,
A friend just linked me to the "Essential3" Ulixacaltamide study. You had mentioned the earlier phases in Nov 2023. I did the "qualification" test online and they said I fit. But when I go to the appointment page to setup an intake call, it says "No times available in February" and won't let me advance to March. Or provide any other contact route.
Searching the web for the Praxis company, it is all about other test failures and the stock price tanking from $20 to $1.
https://www.biopharmadive.com/news/praxis-tremor-trial-results/644117/
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Despite study setback, a biotech plans to push tremor drug into late-stage testing
The trial found the drug was no better than a placebo at improving patients’ condition, as measured by a scorecard used to evaluate the severity of their tremors as well as how they perform daily activities like speaking, writing and standing. However, Praxis said its drug showed small, but statistically significant improvements over placebo on three other scorecards that served as secondary goals of the study.
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The current Phase 3:
https://www.mdsabstracts.org/abstract/essential3-an-innovative-multi-study-phase-3-program-to-evaluate-the-efficacy-and-safety-of-ulixacaltamide/
The intake page:
https://essential3study.com/
Do I even want to be part of this? And maybe get a placebo while wasting lots of time with their representatives? If they will even bother coming out to my very rural location... When their results depend on silly questions about self perception, that disagree with each other?
3/3 With SMwI, doctors have a powerful tool to accurately diagnose Parkinson's disease and essential tremor. This means better treatment and a higher quality of life for patients. #Parkinsons #EssentialTremor #MedicalBreakthrough
Last weekend, I visited my aunt and uncle at their cozy countryside home. My uncle, a retired schoolprincipal, greeted me with his warm smile and a slightly trembling hand as he poured tea into cups #betablockersfortremor #deepbrainstimulation #essentialtremor #lifestyletipsfortremors #Parkinson’sdisease #tremortreatment
Source https://doi.org/10.1016/j.mcn.2010.01.007 "Trk activation in the secretory pathway promotes Golgi fragmentation", cited by https://doi.org/10.1016/j.mcn.2015.11.002 "Intracellular LINGO-1 Negatively Regulates Trk Neurotrophin Receptor Signaling"
LINGO-1 is mutated in some inherited forms of #essentialtremor
"Neuronal Golgi fragments, in the form of dendritically localized Golgi
outposts, are important determinants of dendritic growth and branching." Aberrant dendritic branching and dendritic degeneration is part of the pathophysiology of essential tremor
@axoaxonic
Holly,
Meditating on your reply about "different words", I connected some previously unlinked awarenesses. I'm not aware of "resting tremor". My hands shake only when they require precise control - which may mean movement or stability. I guess that's "intention tremor". But while resting, and clearing my mind of planning intention, I can feel my entire body subtly pulsating at the rate of my hand tremor - but not perceptibly moving. Maybe a background level of brain spiking? When I intend an action, I lose that body awareness, and the pulsation all seems to move into the trembling hand and arm while the rest of me floats in unrelated space.
My hand tremor looks to be typical, just under 6 Hz. I did a multi year test of various CoQ10 supplements in ridiculously huge doses, and then big scoops of "Tremor Miracle" which added vitamins and other stuff. (Looks like they've changed it a lot since then.) I'd put the little iPhone with the TREMOR12 app between my palm and the big glass of liquid, and move the results to Jupyter Notebooks. Looked like the image here, you can see each sip. But no improvement over years of trying.
Maybe unrelated, but I've always consciously seen the pulsation of AC electric lights (and old CRT screens). Over 50 years ago I began converting my home and work lighting to DC. Now I'm lucky to live off-grid, where all my lighting runs directly from the batteries. Without that blessed peacefulness, I doubt I'd be able to feel the subtle background pulsation of my body.
(More thoughts being processed...)
Lab PhD Candidate Hantao Wang presenting at #SfN2024 on speech auditory-motor adaptation with DBS on/off in patients with Parkinson's Disease vs Essential Tremor.
#PD #Parkinson #EssentialTremor #speech
@privateger definitely feeling that as I get older and the #EssentialTremor gets worse...
Introduction post:
I'm an amateur artist who works with lasers because lasers don't care if your hands shake #EssentialTremor
I'm a little neurospicey (late diagnosed ADHD) so this might be a bit scattered.
Final peculiarities: I've got an evil eye from a violent cataract back in '88 (who needs depth perception?), a big ol' chest scar (heart/aorta repair), and a deep voice in case you need something to sound ominous!
Lol @ this study finding that social anxiety and #essentialTremor are correlated, but we don't know which way the causality flows, and then they formulate the hypothesis that it could be social anxiety causing tremor.
I feel like a bit of empathy and imagination should make it obvious that it's difficult to be fully socially confident if you constantly _appear_ to be a nervous wreck. People treat you accordingly. I have like 500 stories if any researchers are interested
Some #essentialTremor news: a pretty serious study by serious people shows a 3x risk of developing dementia compared to the general population.
My (uneducated) take is that this applies more to people who develop it in old age - there's clearly a degenerative process happening if you go from not having it to having it. For people like me who had it all their life with little change it's maybe less clear.
https://www.utsouthwestern.edu/newsroom/articles/year-2024/april-tremor-triples-dementia-risk.html
Finally starting to get somewhere with starting to place things in the greenhouse
#Rolife #minitures #essentialtremor #fibromyalgia #minidollhouses #diy
A day into assembly, acrylic looks so good but is so slow to work with and I'm always afraid I'll break something...
#LaserCut #maker #EssentialTremor
Got something in time for #WipWednesday, a #lasercut jewelry box that the kiddo wants to help me assemble... This will be tricky with my #EssentialTremor so today I sand and assemble the most fiddly bits so we can do the rest together.
Oddly enough, in the aftermath of four hours getting a tattoo, my hands are steadier than they've been in years... Was really expecting to be non functional... #EssentialTremor is wild!
PhD candidate Hantao Wang reporting on his ongoing work at the #MotorSpeech conference in San Diego. Using Local Field Potential recordings from the implanted DBS electrodes in patients with #ParkinsonsDisease or #EssentialTremor. #NIH #NIDCD
Phones with physical buttons are getting phased out, but touchscreens are especially hard to use with #EssentialTremor. Market-driven #engineering tends to neglect accessibility at the hardware design level, instead adding it in as a feature in the software
Little break for catsitting, now I'm in the west end of Fish Creek with this deer my camera doesn't want to see. Should have skipped the beta blocker, though, doesn't matter if I'm shake out here but sure would be easier to walk if I got get over 110bpm... #EssentialTremor #FishCreek
"Overall, we identified four main categories of dysregulation that numerous processes fall into: (1) axonal guidance, (2) microtubule motor activity, (3) ER-Golgi transport, and (4) calcium
signaling/synaptic transmission.
...
It is increasingly likely that multiple dysregulated processes play a role in the etiology of ET, further supporting the hypothesis that ET is a family of related diseases rather than a single entity"
...
"Electron microscopy studies have shown that axonal swellings in ET patients contain an excess of disorganized neurofillaments and organelles (mitochondria and [endoplasmic reticulum]) which accumulate as a result of damaged axonal transport. Trafficking along the axon requires stable microtubule dynamics via dynein-dynactic (retrograde) and kinesin (anterograde) activity"
- Martuscello, et al 2019
There's a lot of evidence showing that essential tremor is a neurodegenerative disease. If it is, how could the degeneration be prevented?
https://tremorjournal.org/articles/10.5334/tohm.227
https://www.sciencedirect.com/science/article/abs/pii/S0074774222000046
https://www.nature.com/articles/nrneurol.2011.44
https://cerebellumandataxias.biomedcentral.com/articles/10.1186/s40673-020-00121-1
https://jamanetwork.com/journals/jamaneurology/fullarticle/798119
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