#hippocampus

What song is Tom Listening To?TomsMusic
2025-05-02
What song is Tom Listening To?TomsMusic
2025-04-30
Pierre Huyghebaertcrickxson@post.lurk.org
2025-04-28

"We now leave #navigation to our #phones. The result: more of us are getting hopelessly lost." #JohnHarris
theguardian.com/commentisfree/
"#GPS has cut us off from a basic human skill. It’s no wonder #mountain #rescuers are being called out so often. [...] Between 2019 and 2024, the total number of #rescues had increased by 24%, and there was a marked jump among the 18 to 24 age group, among whom callouts almost doubled. [...] across #Britain, there is evidently a mounting problem about the gap between people’s urge to experience wild and open spaces, and their ability to cope when they actually get there. [...] research suggesting that “people with greater lifetime GPS experience have worse #spatialmemory during self-guided navigation”. [...] retested 3 years after the initial research, when they found that “greater GPS use since initial testing was associated with a steeper decline in hippocampal-dependent spatial memory”. The #hippocampus is the part of the brain that deals with navigation: among London taxi drivers, the need to memorise so many geographical details was found to cause it to increase in size. But here were findings that suggested the opposite: reliance on automated #directions reducing people’s capacity to navigate for themselves." #cartography
Thx #SophieBerrebi

What song is Tom Listening To?TomsMusic
2025-04-27
2025-04-25

#Hippocampus & #PFC interact to support spatial #WorkingMemory, but are dHPC & vHPC functionally redundant in this? This study shows that both regions contribute differentially to spatial WM & coding of spatial info by PFC @PLOSBiology plos.io/4cXyddO

Top left: Schematic of virus injection and optic fiber implantation in dHPC (left) or vHPC (right) with electrodes implanted in the PFC to record neuronal activity during hippocampal silencing. Right: Example coronal sections showing ArchT-GFP expression in dHPC (top) and vHPC (bottom) with optic fiber placements outlined by dashed white lines. Bottom left: Task schematic. In the sample phase (left), mice were guided to enter one of the two goal arms to receive a reward. After a delay phase in the start box (middle), mice could choose between both goal arms but only received a reward in the goal arm opposite to the one visited in sample (right).
What song is Tom Listening To?TomsMusic
2025-04-18
What song is Tom Listening To?TomsMusic
2025-04-15
What song is Tom Listening To?TomsMusic
2025-04-15
2025-04-09

From the lab of Helene Schmidt:

"Large-scale 3D EM connectomics dataset of mouse hippocampal area CA1", Corteze et al. 2025
biorxiv.org/content/10.1101/20

Spectacular.

#neuroscience #hippocampus #mouse

What song is Tom Listening To?TomsMusic
2025-04-09
What song is Tom Listening To?TomsMusic
2025-04-07
2025-04-04

I keep going back to this question about #TemporalCreditAssignment and #HippocampalReplay:
As an "agent" you want to learn the value of places and which places are likely to lead to reward;

-1) if a place leads to higher than expected reward, you'll want to propagate back the reward info from the reward throughout the places that led to the reward. If replay does that you should see an increase of replay at a new reward site and the replay sequences should start at the reward and reflect what you just did to reach it. Right?

-2) if a place leads to lower than expected reward, you'll also want to propagate that lowered value, pretty much in the same way, so if replay does that you should see a similar replay rate and content for increased OR decreased reward sites. Right?

-3) if a place has had unchanged reward for a while and you're just in exploitation mode (just going there again and again because you know that's the best place to go to in the environment) then you shouldn't need to update anything and replay rate should be quite low at that unchanged reward side. Right?

That's not at all what replay is doing IRL, so does that mean replay is not used for temporal credit assignment? Or did I (very likely) miss something?

#Neuroscience #ComputationalNeuroscience #DecisionMaking #Hippocampus

2025-04-04

Are hippocampal representations of other people anchored to #SelfKnowledge? This study shows other people’s preferences are represented relative to personal preferences in the #hippocampus & dorsomedial prefrontal cortex when retrieving relational social knowledge @PLOSBiology plos.io/449XRcD

Egocentric anchoring-and-adjustment in the hippocampal formation. Top: Neural and behavioral representational dissimilarity matrices (RDMs) for the general linear model (GLM) searchlight analysis for one representative participant. The neural RDM was used as a dependent variable with six predictor behavioral variables. These six variables were the absolute distance between the stranger’s rating and the ratings of the groups that are being compared with the stranger (absolute distance, AD), the differences between self and others’ preferences (rating discrepancy, RD, with either groups or individuals), the cognitive demand of how far the stranger’s preference is away from the individual’s rating (rescaling), and the memory for self and others’ preferences (rating consistency, RC, for groups or individuals). Middle: Group activation maps for self vs. group rating discrepancy (RDgroup).  Bottom right: Beta coefficients of RSA GLM in ROI of dmPFC. Bars showing beta coefficients resulting from the GLM for each behavioral variable in the dmPFC, where there is a significant dmPFC effect for RDgroup (t(19) = 2.92, p = 0.008). Each dot represents an individual participant.
What song is Tom Listening To?TomsMusic
2025-04-02
What song is Tom Listening To?TomsMusic
2025-04-01
What song is Tom Listening To?TomsMusic
2025-03-30
What song is Tom Listening To?TomsMusic
2025-03-29
2025-03-27

#PlaceCells often have elongated place fields next to an environment's boundaries.
Is there any paper where this phenomenon is directly predicted by the #SuccessorRepresentation model of place cells?

#SpatialCognition #Neuroscience #Hippocampus

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