How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD

Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD

Plant Histone Deacetylases: Their Classification and Inhibitor Search - #histonedeacetylases #Arabidopsisthaliana #Oryzasativa #homologyclassification #moleculardocking #inhibitors #histone #Arabidopsis #Oryza - https://link.springer.com/article/10.3103/S0095452724050116

#Strawberry #ripening revealed: Key #histone modifications uncovered

#genomics #ChIP_seq #H3K9_K14ac #H3K27ac #H3K27me3

https://phys.org/news/2024-09-strawberry-ripening-revealed-key-histone.html

Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd

btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports

dear #biology friends... I want to learn more about this:

"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."

Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?

Organization Of DNA In Cell

#ArchaeaDNA, #DNA, #Histone, #Nucleosomes, #Supercoil #Genetics All living cells contain DNA in the form of double helix, its organization differs among cells in the three domains…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/27/organization-of-dna-in-cell/

Deciphering the Blueprint of Life: Exploring the Structure of DNA

#Adenine, #Blueprint, #Cytosine, #DeoxyriboseSugar, #DNA, #DNACoiling, #DoubleHelix, #Guanine, #Histone, #MajorGroove, #MinorGroove, #NitrogenousBases, #Nucleotide, #Phosphate, #StructureOfDNA, #Thymine, #WatsonAndCrick #Biochemistry, #Genetics The discovery of the structure of DNA stands as one of the most significant milestones in the history of science. Deoxyribonucleic acid, or DNA, is the molecule…

https://micrordt.wordpress.com/2024/04/27/deciphering-the-blueprint-of-life-exploring-the-structure-of-dna/

IOB
“…here, we screen #histone #acetylation in the house #sparrow; we studied this species because #DNA #methylation was important in the spread of this #bird globally."
doi.org/10.1093/iob/ob…
by Ray, Sheldon (@)cedzimmer , (@)MartinlabUSF
(@)Big_Biology ) , Schrey

#epigenetic #bio

https://doi.org/10.1093/iob/obae004

"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"

https://elifesciences.org/articles/86823

Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.

This happens not only in the brain, but apparently also in the placenta, this new paper shows:

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454

#epigenetics #histone

How do plants memorize heat exposure to be primed for future #heatstress?

Isabel Bäurle et al show that selective #histone retention helps to preserve #chromatin marks specifically at heat-induced genes in #Arabidopsis

https://www.embopress.org/doi/full/10.15252/embj.2023113595

The cell's 'read–write' mechanism: Researchers uncover how instructions for #gene #expression are relayed.

#Epigenetic #histone #p300_CBP #acetylation

https://phys.org/news/2023-11-cell-readwrite-mechanism-uncover-gene.html

A role for #HistoneMethylation in metabolic regulation? #Histone methyltransferases are co-regulated by #TumorSuppressor Rb; altered expression controlled by Rb leads to reorganization of S-adenosyl methionine metabolism @PSarkies #PLOSBiology https://plos.io/3MhUfM4

Discovery of #histidine methylation as a new post-#translational modification of #histone proteins.

#DNA

https://phys.org/news/2023-09-discovery-histidine-methylation-post-translational-modification.html

Global histone H2B degradation regulates #insulin/#IGF signaling-mediated nutrient stress

The #ubiquitin-#proteasome system regulates #histone #H2B exchange in mammalian cells and in C. elegans during development and starvation.

https://www.embopress.org/doi/full/10.15252/embj.2022113328

"CD8+ Teff cells preferentially used #ketone bodies (KBs) over #glucose to fuel the tricarboxylic acid (TCA) cycle in vitro and in vivo. KBs directly boosted the respiratory capacity and TCA cycle-dependent metabolic pathways that fuel CD8+ T cell function. Mechanistically, βOHB was a major substrate for acetyl-CoA production in CD8+ T cells and regulated effector responses through effects on #histone #acetylation"

https://www.cell.com/immunity/fulltext/S1074-7613(23)00314-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS107476132300314X%3Fshowall%3Dtrue

How can #replication initiator ORC load replicative #helicases in condensed chromatin?
Structural and biochemical work by Franziska Bleichert and colleagues shows how ORCA recruits ORC to certain #histone marks, and also reorganizes local #chromatin structure
https://www.embopress.org/doi/full/10.15252/embj.2023114654

Insights into the action of plant #WRKY #transcription factors: Interaction with #histone-binding #OBERON proteins forms repressive complexes keeping drought stress response genes in check
https://www.embopress.org/doi/full/10.15252/embj.2023113639