#hypothyroidism

Johannes W. Dietrichdrjwdietrich@qoto.org
2025-08-21

There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.

pubmed.ncbi.nlm.nih.gov/392901

Forest plot of patient preferences (combination therapy vs monotherapy) across all 11 selected studies, showing a significant preference for combination therapy in studies of 12 weeks of follow-up or longer.Pie chart depicting patients’ preferences at the end of the crossover study periods: A) including all crossover studies and B) after the exclusion of three studies, following funnel plot analysis. More patients prefer the combination therapy of L-T4 and L-T3 over L-T4 alone.
Johannes W. Dietrichdrjwdietrich@qoto.org
2025-08-17

Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study.

pubmed.ncbi.nlm.nih.gov/405791

doi.org/10.1210/clinem/dgaf367

Table showing increased risk of dementia, atrial fibrillation and fatality in patients with treated hypothyroidism in a follow-up of 20 yearsForest plot showing increased risk of dementia in patients with treated hypothyroidismTable with the results of multivariable regression analysis, showing significantly increased risk for dementia and fatality in monotherapy with L-T4 compared to combination therapy of L-T4 and L-T3 or DTE
Johannes W. Dietrichdrjwdietrich@qoto.org
2025-07-26

#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes.

#hypothyroidism #thyroid #SORSHOT

doi.org/10.1007/978-981-96-368

Therapeutic flow chart: Proposed algorithm for the treatment of syndrome T (SORSHOT). The approach includes optimising dosage and modality of treatment, considering treatment with L-T3, treating common and important comorbidities and correcting mineral and vitamin deficiencies.

Well, not the happiest intro but I’ll cut/paste this here while I still remember then add a proper intro spoons allowing..⬇️

Please #boost and share to other platforms spoons allowing.

Seems I’m desperate enough to go to the media for help. Yes, the trapped woman in the article below is me.

My story: thecanary.co/global/world-anal

More info on how to help:: buymeacoffee.com/halcionandon/
Beem: Halcionandon

I’ve tried every level of government and they simply won’t help.
- Please ask people if they have a spare room or somewhere to go. Maybe you have somewhere?
- Is anybody a #DisabilityAdvocate? #SocialWorker? Need help.

Please don’t give me contacts for domestic violence orgs. They don’t help disabled people with housing & only offer counselling. Also, that list of disability advocates going around for #Melbourne #Australia (where I am) is outdated - there aren’t any in my catchment. So I’m looking for volunteers with some background.

Thanks for reading

#PwME #LongCovid #MECFS #Hypothyroidism #ChronicIllness #Neisvoid #NacissisticAbuse ##Housing #Dysautonomia #SocialWork #MedMastodon #PWLC #MutualAid
#HumanRights #Press

@mecfs @chronicillness @neisvoid
@disability @disabilityjustice @socialwork @mutualaid
@chronicillness

2025-06-21

"Doctor, what is it?"

"Bad news, I'm afraid."

"Give it to me straight."

"You suffer from hippothyroidism."

"Oh, it just means my thyroid is not producing enough. Not that big of a deal, right?"

"I said hippothyroidism, not hypothyroidism. You have the thyroid of a horse."

"Oh. May I ask a question?"

"Go ahead."

"Which horse is it whose thyroid I have?"

"The maternity test was inconclusive. We're thinking seahorse."

"What's the treatment?"

"Buy yourself water wings and wear them 24/7."

(This story was brought to you by someone who has hypothyroidism. :derpface: )

#hypothyroidism #horses #seahorses #doctors #microfiction

2025-05-31

Computer simulations with #SimThyr enhance our understanding of the physiology of hypothalamic-pituitary-thyroid feedback control. This applies, for example, to the evolution of #TACITUS syndrome.

#thyroid #hypothyroidism #NTIS #biocybernetics

doi.org/10.1007/978-981-96-368

Figure from the book "Hypothyroidism: A Paradigm Shift" by Hoermann and Dietrich: Combination of peripheral and central mechanisms leading to the low-T3 syndrome. The activities of peripheral (GD1) and central (GD2) deiodinases diverge to cause the low-T3 phenotype. The graph shown has been produced by computer simulation with the free app SimThyr.
Johannes W. Dietrichdrjwdietrich@qoto.org
2025-05-27

Our eBook on #hypothyroidism has been published. The new cybernetic theory presented here summarises our scientific work of more than 20 years and lays the foundation for improved diagnosis and therapy of #thyroid disorders.

The book is available in EPUB and PDF formats.

doi.org/10.1007/978-981-96-368

Title page of the book "Hypothyroidism" by Hoermann and Dietrich.

This book revolutionizes our understanding of the regulation of the hypothalamic-pituitary-thyroid axis and the homeostasis of the thyroid system, offering a groundbreaking framework for diagnosing and treating hypothyroidism. By challenging conventional approaches, it addresses the pressing need for improved treatment quality, especially for patients experiencing persistent symptoms despite standard levothyroxine therapy. Delve into a comprehensive exploration of hypothyroidism, from its definition and pathophysiology to patient presentation and endocrine regulation. The chapters illuminate critical topics such as iodine metabolism, thyroid hormone signaling, and the intricacies of the hypothalamic-pituitary-thyroid axis. With contributions from leading experts, this book presents a paradigm shift in clinical care by integrating recent advances in thyroid regulation into practical treatment strategies. Readers will uncover why many patients fail to respond adequately to current treatments and discover innovative approaches to diagnosis and therapy. Ideal for medical professionals, researchers, clinicians, and specialists interested in thyroid disease, this book is also invaluable for general practitioners and informed patients seeking deeper insights into their condition. Aspiring endocrinologists will find it particularly educational, aligning with curriculum requirements while offering a fresh perspective..
2025-05-26

'Alterations of #Brain white matter network topological properties in overt #Hypothyroidism' - a Society for #Endocrinology #Research article by Bioscientifica on #ScienceOpen: scienceopen.com/document?vid=3

SCAB Pharmacy Limitedscabpharmacy@mastodon.africa
2025-05-25

𝗪𝗼𝗿𝗹𝗱 𝗧𝗵𝘆𝗿𝗼𝗶𝗱 𝗗𝗮𝘆 | 𝟮𝟱 𝗠𝗮𝘆 𝟮𝟬𝟮𝟱
𝗧𝗵𝘆𝗿𝗼𝗶𝗱 𝗛𝗲𝗮𝗹𝘁𝗵 𝗶𝘀 𝗚𝗹𝗼𝗯𝗮𝗹 𝗛𝗲𝗮𝗹𝘁𝗵

Thyroid disorders affect over 100 crore people worldwide. From iodine-deficient regions in Southeast Asia, South America, and Central Africa to urban centers everywhere, thyroid diseases are among the most common endocrine disorders globally.

𝗪𝗵𝘆 𝗼𝗯𝘀𝗲𝗿𝘃𝗲 𝗪𝗼𝗿𝗹𝗱 𝗧𝗵𝘆𝗿𝗼𝗶𝗱 𝗗𝗮𝘆?

To raise global awareness about thyroid disease burden
To promote early diagnosis and treatment across all populations
To highlight the critical role of iodine and the impact of its deficiency or excess
To encourage healthy lifestyle practices worldwide to support thyroid health

𝗚𝗹𝗼𝗯𝗮𝗹 𝗣𝗿𝗲𝘃𝗲𝗻𝘁𝗶𝗼𝗻 𝗧𝗶𝗽𝘀:

Ensure adequate iodine intake through diet or iodised salt
Promote awareness and education about thyroid symptoms and screenings
Avoid tobacco and limit alcohol consumption
Manage stress and ensure sufficient sleep
Encourage regular medical check-ups for early detection

Together, let's fight thyroid disease for healthier communities everywhere.

#WorldThyroidDay #GlobalThyroidHealth #ThyroidAwareness #EndocrineHealth #IodineDeficiency #ThyroidDiseasePrevention #Hypothyroidism #Hyperthyroidism #ThyroidCare #SCABPharmacy

All Scientificalallscientifical
2025-04-25

What processes are observed in the body with hypothyroidism?

There is a risk of edema due to fluid retention, metabolic processes slow down, the concentration of cholesterol increases and a decrease in the metabolism of fats and cholesterol is noticed.

Johannes W. Dietrichdrjwdietrich@qoto.org
2025-04-20

Interestingly, both subclinical #hypothyroidism and #thyrotoxicosis predict #MACE. The free thyroxine (FT4) concentration is more associated with the HR for cardiovascular events than thyrotropin (TSH) levels. Our observations yield an integrated model including psychosocial and somatic mechanisms.

An integrated model for the association between thyroid homeostasis and major cardiovascular events. In the dyshomeostatic type of thyrogenic arrhythmia elevated FT4 concentration, caused by primary thyrotoxicosis, increases the risk for severe arrhythmia as a major cause for cardiovascular mortality. The TSH concentration is reduced in this case, represented by the left, declining, branch of the U-shaped relation between TSH level and risk (A). In the allostatic type, mainly caused by type 2 allostatic load and genetic traits, the set point of thyroid homeostasis is raised, resulting in increased TSH and FT4 concentration and subsequently elevated risk for arrhythmia. This situation is mirrored in the right, rising, branch of the relation between TSH concentration and cardiovascular risk (B). In any case, elevated concentrations of T3, T4 and other T3-agonistic thyroid hormones increase the sensitivity to catecholamines and sympathetic signaling (via upregulated expression of beta1 and beta2 adrenoceptors), thereby contributing to reduced stress tolerance. SPINA-GT, “gain of thyroid,” i.e., thyroid’s secretory capacity.

PLEASE HELP ME ESCAPE!

Please #boost and share to other platforms.🙏I don’t have energy left (see below).

Seems I’m famous (and real!) and desperate enough to go to the media for help. Yes, the trapped woman in the articles below is me.

👉Last year:
thecanary.co/global/world-anal

Now things are worse, I’m much sicker, being neglected and will die without a safe stable #home. Doctor’s words.

If not mentioned in the article, my father is a diagnosed #narcissist with #psychopathic & #antisocial tendencies by a #psychiatrist. He urged me get away from my father asap because he is not a ‘safe person’ & neither are the other family members who lured me back through the promise of help.They didn’t help they made me progressively worse to the point of almost incapacitation at stage of #illness.

👉A year later:
thecanary.co/global/world-anal

I’ve tried every level of government, every service and they simply won’t help.

Are able help? Please ask people in real life if they have somewhere for me to go. Could they take me in (I can pay small rent)? A lot people have ‘big house, not enough money’ problem. I can help!

Is anybody an #advocate? I desperately need help.

I would be incredibly grateful for any help beyond words.🙏

Please read articles for full information.

Thank you for reading.

#PwME #LongCovid #MECFS #Hypothyroidism #ChronicIllness #Neisvoid #Abuse #Housing #Dysautonomia #SocialWork #MedMastodon #PWLC #MutualAid
#HumanRights #Press #Housing #Journalism #MECFS #SevereME #Abuse #Neglect #MutualAid #Narcissist #Psychopath

Woman bed in a very dark room with ear defenders and light block glasses.

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