#Hematopoietic #stemcells undergo a #lymphoid-to-#myeloid switch in early stages of emergency #granulopoiesis
Karolína Vaníčková, Meritxell Alberich-Jorda et al
https://www.embopress.org/doi/full/10.15252/embj.2023113527

Transcriptional and #chromatin profiling of human blood innate #lymphoid cell subsets sheds light on #HIV1 pathogenesis
Luban Lab and collaborators
https://www.embopress.org/doi/full/10.15252/embj.2023114153

Murine #COVID19 #lethality is characterized by #lymphoid depletion associated with suppressed #antigen presenting cell functionality https://ajp.amjpathol.org/article/S0002-9440(23)00119-0/fulltext?rss=yes

A particular focus is #lymphoid tissues that produce, store and carry #Tcells that fight infection, and #antibody-making #Bcells.

The coronavirus may also be hiding out in long-lived #nerve cells and #heart muscle, where it may drive chest #pain, brain fog, #fatigue and other long-Covid symptoms, said Diane Griffin, a virologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore who has studied the body’s response to viral infections for more than 50 years.

“We have pretty good information from acute #RNA #virus infections that RNA does persist and that it does have consequences,” said Griffin, who is vice president of the US National Academy of Sciences. “Basically, it’s hard to get rid of viruses.”

Proving that persistent viral #infection causes long Covid will be difficult, Griffin said. Viruses in stealth mode suppress replication to avoid harming their host cells.

Despite extensive distribution of coronavirus RNA throughout patients’ bodies, Chertow’s team saw little evidence of inflammation or that the immune system had tried to destroy infected cells outside the respiratory tract.

(4/n)

https://www.bloomberg.com/news/features/2023-03-01/hidden-viruses-in-your-body-could-answer-why-long-covid-lingers?leadSource=uverify%20wall

Protecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2

Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology