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#misfolded

John Vaccaro (johniac)johniac
2025-05-05

SciTech Chronicles. . . . .May 5th, 2025

bit.ly/stc050525

#"B2 quadruped" #"extreme environment" #"water Cannon" -PSCAN

PLOS BiologyPLOSBiology@fediscience.org
2025-04-10

TMED9 mediates export of misfolded #prion proteins from the ER. This study shows that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @PLOSBiology plos.io/44kURu5

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.
Scientific Frontlinesflorg
2023-02-02

Many disorders arise from damage to due to a build-up of or aggregated in the brain, like the tau protein and the -beta protein.

sflorg.com/2023/02/ns02022301.

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