Fully Funded PhD Position in Cancer Research
Hebrew University of Jerusalem
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606
#autophagy #cancer_biology #cell_death #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
Research uncovers specific #protein interactions needed for #cells to break down and remove damaged #mitochondria.
https://phys.org/news/2024-03-uncovers-specific-protein-interactions-cells.html
The ER membrane protein complex restricts #mitophagy by controlling BNIP3 turnover
Jose Delgado, Samantha Liu, Christopher Shoemaker et al
https://www.embopress.org/doi/full/10.1038/s44318-023-00006-z
• Hormones #metabolism is intricately linked to #mitochondrial quality-control.
• #Hormones regulate both mitochondria & #mitophagy.
• Dysregulated mitophagy contribute to development of #endocrine disorders.
• Targeting mitophagy is an innovative approach for treating ED.
https://www.sciencedirect.com/science/article/pii/S0753332223012660
Circadian nature of #mitochondria
NR1D1 bridges #circadian clock & UC, controlling BNIP3-mediated #mitophagy & representing potential therapeutic target. Its agonist, SR9009, shows promise in UC symptom alleviation.
https://www.mdpi.com/1422-0067/24/18/14222
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165
Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1
Debasna Panigrahi, Sujit Bhutia identify MTP18 as a novel #mitophagy receptor and discover that MTP18-dependent mitophagy has implications in oral #cancer progression.
https://journals.biologists.com/jcs/article/136/13/jcs259986/323419/The-inner-mitochondrial-membrane-fission-protein
You can read more about this research in our ‘First person’ interview with Debasna Panigrahi: https://journals.biologists.com/jcs/article/136/13/jcs261435/323418/First-person-Debasna-Panigrahi
Exploitation of host cell #organelles by an intracellular #pathogen: #Brucella abortus not only uses the ER to replicate, but later also localizes to and fragments #mitochondria to aid bacterial egress via #mitophagy
Thierry Arnould et al
https://www.embopress.org/doi/10.15252/embj.2022112817
How are specific dysfunctional #mitochondria removed under steady-state conditions?
Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors
What controls basal, #Parkin-independent #mitophagy?
E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively
Congrats Iannis! Looking forward to reading the manuscript!
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RT @iannisaifantis1
Excited to share one more 2023 research story from our lab, out today @CD_AACR identifying #Mitochondria and #Mitophagy as a key regulator of Venetoclax and MCL1i resistance in AML. The work was led by @glytsou and @xufeng_chen ...@nyugrossman (1)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0601/719030/Mitophagy-pro…
https://twitter.com/iannisaifantis1/status/1650521572937986050
Interesting new paper from Orian Shirihai's group in @embojournal
"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
https://www.embopress.org/doi/full/10.15252/embj.2022111699
Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast 🎧 👇
#mitochondria #mitophagy #metabolism
https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/
