[biological evolution] Whole-genome duplication drives long-term adaptation
https://www.sciencedaily.com/releases/2025/03/250326221649.htm
https://news.ycombinator.com/item?id=43515443
Genome duplication in a long-term multicellularity evolution experiment
https://www.nature.com/articles/s41586-025-08689-6
#yeast #MolecularBiology #evolution #genetics #MolecularGenetics #multicellularity #adaptation #genomics #GenomeDuplication #CellBiology
Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
https://www.sciencedaily.com/releases/2025/03/250320144758.htm
https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer
* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material
Structural dynamics of DNA unwinding by a replicative helicase
https://www.nature.com/articles/s41586-025-08766-w#Sec25
#cancer #MolecularGenetics #StructuralBiology #DNAreplication #DNAhelicase
Mitochondria as youโve never seen them
https://www.nature.com/immersive/d41586-025-00269-y/index.html
https://news.ycombinator.com/item?id=42899168
Comments
me: former mitochondrial (mt) researcher, published
mt difficult to prepare/isolate intact/pure
extraordinary imagery shows why
Yet another "illustration" ๐ of crit imp. of fundamental research
https://www.niehs.nih.gov/research/atniehs/labs/gisbl/pi/mdnar
https://tools.niehs.nih.gov/polg/ --> mt. diseases ...
https://en.wikipedia.org/wiki/Mitochondrial_disease
#BasicScience #mitochondria #CellBiology #PolG #disease #BasicResearch #MolecularGenetics #PEO #mtDNA #NIEHS
Top 10 discoveries about ancient people from DNA in 2023
https://johnhawks.net/weblog/the-top-10-discoveries-about-ancient-people-from-dna-in-2023
https://news.ycombinator.com/item?id=42033913
#DNA #AncientDNA #MolecularGenetics #evolution #EvolutionaryGenetics #polymorphisms #SNPs #anthropology #history
Prevalence of Problematic Papers in Non-Coding RNA Research
https://www.biorxiv.org/content/10.1101/2024.08.28.607530v1?rss=1
* prevalence of problematic papers in field of non-coding RNA (ncRNA) research
* 1.79% retracted; 5.68% raised concerns on PubPeer
* unreliable papers widely disseminated
* hundreds of thousands citations
* significant threat to research integrity / public health
#biology #MolecularBiology #MolecularGenetics #PeerReview #PubPeer #AcademicPublishing #AcademicJournals #RNA #ncRNA #FraudulentScience #JunkScience
Nonlinear dynamics of multi-omics profiles during human aging
https://www.nature.com/articles/s43587-024-00692-2
* Stanford; Mike Snyder well-known
* aging a complex process associated w. nearly all diseases (aging-related diseases)
* understanding molecular changes underlying aging
* consistent nonlinear patterns in molecular markers of aging
* substantial dysregulation at two major periods occurring at ~44โ& ~60โyears chronological age
* distinct molecules, functional pathways
Grolar bear hybrids in N.W.T. all traced back to same 'strange' female polar bear
New genetic sequencing tool shows family of western Arctic hybrids are 'quite rare'
https://www.cbc.ca/news/canada/north/polar-bear-grizzly-study-1.7239850
Development of an 8K SNP chip to assess adaptive diversity and hybridization in polar bears
https://link.springer.com/article/10.1007/s12686-024-01359-1
#Arctic #bears #Ursus #PolarBears UrsusMaritimus #GrizzlyBear #UrsusArctos #HybridSpecies #ecology #NGS #MolecularGenetics
Unlocking the secrets of life, one strand at a time! Happy National DNA Day! ๐งฌ #dnaday #genetics #dnagenetics #genes #genome #bsbmemorie #molecularbiology #frickandfrackbsb #genomics #crispr #cellbiology #microbiology #geneticist #crisprcas #geneediting #studygenetics #researcher #researchers #geneticengineering #microbiologist #microbiologia #laboratoryequipment #moleculargenetics #sciencepodcast #sciencecommunication #geneticcounselor #geneticcounseling #gene #nutrigenomics
Also I started posting page by page commentary a while back, on The Seven #Daughters of #Eve by Professor Brian Sykes. #molecularBiology #molecularGenetics #BioInformatics #girlPower
https://1234.as/@jenny_wu/109686480388953569
Retoots plz?
A remarkable book on many of #India's most remarkable #scientists and the challenges these women have faced and surmounted in #wildlife research and #conservation. From #turtles to #tigers, #butterflies to #birds and #restoration to #moleculargenetics.
#nature #womeninscience #academicchatter #academicmastodon #books #bookstodon #naturewriting #biography
https://www.cntraveller.in/story/the-stories-of-women-wildlife-conservationists-are-very-different-from-those-of-men/
Addendum 2
Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation
https://www.biorxiv.org/content/10.1101/2023.09.07.556677v1?rss=1
* tardigrades survive doses of ionizing radiation 1000x human lethal dose
* specific, robust response to ionizing radiation
* irradiation induces rapid dramatic upregulation of DNA repair genes
#nematodes #cryptobiosis #tardigrades #permafrost #DNArepair #MolecularBiology #MolecularGenetics #DNAdamage
This, Science magazine 2016, is older (still an incredible achievement) but recent discussion:
Design and synthesis of a minimal bacterial genome
https://www.science.org/doi/10.1126/science.aad6253
Discussion: https://news.ycombinator.com/item?id=36626656
A goal in biology is to understand the molecular and biological function of every gene in a cell. One way to approach this is to build a minimal genome that includes only the genes essential for life. ...
#MolecularGenetics #SyntheticBiology #MinimalGenome #genomics #MolecularFunction
[thread] {digital | cognitive} twins
Interesting intersection of informatics (data storage), nanotechnology (DNA oligomers / molecular genetics), digital realities (digital twins)! ๐
Digital twin for DNA data storage based on comprehensive quantification of errors & biases
https://www.biorxiv.org/content/10.1101/2023.07.04.547683v1?rss=1
DNA digital data storage
https://en.wikipedia.org/wiki/DNA_digital_data_storage
Digital twins
https://en.wikipedia.org/wiki/Digital_twin
#DNAdataStorage #informatics #DigitalTwins #modeling #ErrorCorrection #EmergingTechnologies #MolecularGenetics
How the motion of DNA controls gene activity
https://www.sciencedaily.com/releases/2023/06/230629193228.htm
Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion. This allows specific regions to come into contact and thereby activate a gene. A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA.
...
#DNA #DNAexpression #genetics #GeneRegulation #chromosomes #MolecularGenetics
Lets discover all about #biology #cellbiology #neurobiology #genetics #molecular_genetics and other biology stuff!
#biology #neurobiology #genetics #dna #moleculargenetics #cellbiology #science #proscience #chemics #TheMysteriesOfScience #TheMysteriesOfGenetics #sleepyicedragon #sleepyicedragonRNDM #genes
I love new methods that make everything I learned in grad school obsolete. NEB HiFi cloning 3-fragment assembly scaled down to 6-ul reactions transformed into 1/4 of a โsingleโ comp cell aliquot in strip tube. 300 ul SOC, streak 100 ul on a plate, and pick two colonies. Send one for whole-plasmid sequencing (Primodium or Plasmidsaurus) without screening. Perfect. #cloning #molecularGenetics
Hey #MetroVan and #LowerMainland, anyone in #MolecularGenetics looking for new jobs check out this new posting for a research technician here at the AGC. Great environment and really cool projects happening! Apply here: https://tre.tbe.taleo.net/tre01/ats/careers/v2/viewRequisition?org=JT63GS&cws=37&rid=2600
About the work and the author:
#anthropology
#book
#books
#genomics
#molecularbiology
#moleculargenetics
#readingNow
#science
#scienceFedi
In the fall of 1991, a couple of German hikers climbing the Italian Alps discovered a frozen, thawing human corpse. This seeming tragedy turned out to be a surprising scientific discovery, after radiocarbon dating revealed that the body was at least 5000 years old. The fact that it had been frozen for so long meant that ancient human DNA could potentially be recovered for the first time.
#anthropology
#book
#books
#genomics
#molecularbiology
#moleculargenetics
#readingNow
#science
