Looking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying.
https://scitechdaily.com/needle-free-new-nano-vaccine-effective-against-all-covid-19-variants/
https://onlinelibrary.wiley.com/doi/10.1002/advs.202404159
https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202404159
Excellent workshop review on #MucosalImmunity and #SarsCoV2 #vaccines really underscores how challenging mucosal vaccines are to develop, and how large the knowledge gaps are.
A useful counterpoint to the loud voices over the last couple of years that implied this was an easy problem and we should already be fielding them.
few months ago putting something up my nose seemed fine b/c i didn’t think there was anything that could trigger #mucosalImmunity
had VERY low expectations for #Novavax but it actually triggers mucosal response in my actual experience of someone who was pre-Pandemic highly susceptible to coronaviruses
Novavax reports also refer to mucosal response
HOWEVER, the KEY point is WE ALL NEED ACCESS TO AT LEAST 2 primary shots preferably 3 in order to get the ideal response & my fear is we won’t
isn’t #XBB116 rising quick & fast in India? But don’t worry, if you’re on the #alwaysInfected plan, it’ll be mild🤡
this is how #variants spread #mutate & accelerate spread
people need to stop looking to celebrities & public figures for #publicHealth guidance
#wearADamnMask #novavax #HEPA #covidIsNotOver no matter how much you wish it to be. You’re not 5 yrs old; grow tf up #zeroCovid #NoCovid #iWantMyNovavaxNow #matrixM #mucosalimmunity sord of.. #seeingIsBelieving
@SalinasLab has a cool paper describing nasal associated lymphoid tissue (NALT) as a site for #Bcell and #Tcell #immune responses in fish #mucosalimmunity #evolution https://doi.org/10.4049/jimmunol.2200396
