#CRISPR can improve disease resistance in #wheat by giving access to a broader range of solutions beyond random #mutagenesis or intraspecific variation. #Geneediting can unlock new ways to improve crops & speed up #plantbreeding for resistance to crop diseases: https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1542487/

Using the transposon-associated TnpB to improve the efficiency of #CRISPR/Cas-9 #gene editing may prove to be a valuable tool to improve #crop yield and quality of #medicinal #plants
https://doi.org/10.1111/jipb.13758
@wileyplantsci
#PlantScience #JIPB #Arabidopsis #mutagenesis #botany

Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R

Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.

Ancient #volcanoes poisoned #ferns for millions of years https://www.earth.com/news/ancient-volcanoes-chaos-poisoned-ferns-for-millions-of-years/

#Climate-forced Hg-remobilization associated with fern #mutagenesis in the aftermath of the end-#Triassic #extinction https://www.nature.com/articles/s41467-024-47922-0

"the initial volcanic eruptions caused a dramatic shift in the planet’s climate. However, the environmental consequences unfolded over millions of years. Mercury contamination lingered in the environment, poisoning ecosystems long after the immediate extinction event."

🍽️You'd be stressed too if you had 10 billion people coming for dinner...😳

Using #CRISPR for targeted #mutagenesis on important #crop species like broomcorn #millet may help meet the growing need for global #FoodSecurity.

https://doi.org/10.1111/jipb.13669
@wileyplantsci
#JIPB #PlantSci #botany

#Epistasis mediates the evolution of #receptor binding mode in recent #human #H3N2 #hemagglutinin, Nat Commun.: https://www.nature.com/articles/s41467-024-49487-4

Combinatorial #mutagenesis reveals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter compatibility with a common egg-adaptive mutation in seasonal influenza vaccines. Our findings elucidate role of epistasis in shaping recent evolution of human hemagglutinin & substantiate high evolvability of its receptor-binding mode.

I am constantly amazed that the older folks around here aren't all dead of chemical-caused cancer, given how much Roundup and pesticides are applied to their yards. (These folks pay for monthly chemical dousing, even if there are NO PESTS to apply those chemicals too -- we call it the Visit From The Merchants Of Death). #chemicals #mutagenesis #pesticides

#Organic farming is dishonest when it comes to genetic engineering as it also uses #GMO varieties—namely those developed by #mutagenesis. Costs of #GMOs are driven by approval hurdles, not patents: https://www-topagrar-com.translate.goog/acker/news/prof-qaim-haelt-oekolandbau-fuer-unehrlich-20001615.html?_x_tr_sl=de&_x_tr_tl=en #biotech #patents (1/2)

#CRISPR/Cas9-mediated targeted #mutagenesis of #inulin #biosynthesis in rubber #dandelion.

#Taraxacum #1_FFT

https://phys.org/news/2024-02-crisprcas9-mutagenesis-inulin-biosynthesis-rubber.html

Open for feedback: EU legal framework for plants obtained by targeted #mutagenesis & #cisgenesis and for their food & feed products. https://ec.europa.eu/info/law/better-regulation/have-your-say/initiatives/13119-Legislation-for-plants-produced-by-certain-new-genomic-techniques_en #plantbreeding #geneediting

Why #CRISPR? Traditional chemical & physical #mutagenesis affects non-target loci, i.e. many crops are needed for visual screening & it's laborious to identify desirable mutants, which are rare due to non-targeted #mutation & poor agronomic performance: https://doi.org/10.1080/21645698.2023.2243041

Some #AntiviralDrugs act by triggering viral "Death by #Mutagenesis", but could this accelerate evolution of variants-of-concern? @Gabriela3001 @TPilpel @DrMANowak use a math framework to ask whether such treatments are evolutionarily safe #PLOSBiology https://plos.io/45mSjJe

Interesante se logro obtener mutantes promisorios en la variedad de #jamaica UAN-8 con dosis de radiación gamma de 100 a 300 Gy https://doi.org/10.29312/remexca.v14i5.3010 #variación #mutagénesis #mutantes

*Random* #mutagenesis, i.e. inducing spontaneous genetic #mutations in plants that *may* result in desirable traits, is OK as it has "a long safety record" (since before 2001). But #GMOs (around since 1996) are not, & more precise #geneediting is neither: https://www.euractiv.com/section/agriculture-food/news/eu-court-exempts-gene-modification-technique-from-stricter-rules

@Associazione_Rurale_Italiana

La décision de la CJUE de ne pas faire tomber la mutagénèse in vitro sous la réglementation OGM ouvre un boulevard à un futur dans lequel il serait impossible de savoir si ce qu'on mange et plante est susceptible d'être breveté par les industries OGM.

#GMO #agroecologie #law #mutagenesis #biology #biologie #engineering #eu #justice

RT @EUCourtPress: #ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

🐦🔗: https://n.respublicae.eu/EURLex/status/1622902274040160257

#ECJ specifies the status of in vitro random #mutagenesis having regard to the #GMO Directive #environment 👉 https://curia.europa.eu/jcms/jcms/Jo2_7052/

#SarsCov2 has killed more than 6.8 mn people over past 3 yrs all over the world.
On November, Merck finished trial of #molnupiravir,a 5-days pill treatment for patients at risk of severe #COVID but it was authorized in US and UK in late 2021 coz it lowered chance of hospitalization or death by about 30%
This oral antiviral drug kills #nCov19 virus inducing mutations:
lethal #mutagenesis capability.
Now it's reported that #MerckPill could be giving rise to new mutations of virus in some patients

High-throughput #saturation #mutagenesis generates a high-affinity #antibody against #SARS-CoV-2 #variants using protein surface display assay on a human cell https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011119

Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria
#mutagenesis

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad003/7009119